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    Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18537, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pcmt1provided by MGI
    Official Full Name
    protein-L-isoaspartate (D-aspartate) O-methyltransferase 1provided by MGI
    Primary source
    MGI:MGI:97502
    See related
    Ensembl:ENSMUSG00000019795
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PI; PIMT; C79501
    Expression
    Ubiquitous expression in testis adult (RPKM 29.8), cerebellum adult (RPKM 17.1) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pcmt1 in Genome Data Viewer
    Location:
    10 A1; 10 2.26 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (7503609..7557101, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (7627845..7681337, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (7350034..7383382, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene UL16 binding protein 1 Neighboring gene predicted gene, 46209 Neighboring gene predicted gene 16254 Neighboring gene low density lipoprotein receptor-related protein 11 Neighboring gene RIKEN cDNA A630066F11 gene Neighboring gene nucleoporin 43 Neighboring gene large tumor suppressor Neighboring gene katanin p60 (ATPase-containing) subunit A1 Neighboring gene glycoprotein integral membrane 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein-L-isoaspartate(D-aspartate) O-methyltransferase
    Names
    L-isoaspartyl protein carboxyl methyltransferase
    protein L-isoaspartyl/D-aspartyl methyltransferase
    protein carboxyl methyltransferase
    protein-beta-aspartate methyltransferase
    NP_001334157.1
    NP_001345576.1
    NP_001345578.1
    NP_001345580.1
    NP_001345581.1
    NP_001345582.1
    NP_001345583.1
    NP_001345586.1
    NP_032812.2
    XP_006512652.1
    XP_006512658.1
    XP_011241442.1
    XP_011241443.1
    XP_017169321.1
    XP_030100802.1
    XP_030100803.1
    XP_030100804.1
    XP_030100805.1
    XP_030100806.1
    XP_030100807.1
    XP_030100808.1
    XP_036011568.1
    XP_036011569.1
    XP_036011570.1
    XP_036011571.1
    XP_036011572.1
    XP_036011573.1
    XP_036011574.1
    XP_036011575.1
    XP_036011576.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347228.2NP_001334157.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156391, AK003949, AK075632, AK148789, AK149227, AW494723, BG086679, BQ176229, BY099821
      Consensus CDS
      CCDS83677.1
      UniProtKB/TrEMBL
      E0CYV0, Q8BPI6
      Related
      ENSMUSP00000123866.2, ENSMUST00000162606.8
      Conserved Domains (1) summary
      pfam01135
      Location:66274
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    2. NM_001358647.1NP_001345576.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC156391, AK075632, AK148789, AW494723, BY099821
      Conserved Domains (1) summary
      cl28095
      Location:66226
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    3. NM_001358649.2NP_001345578.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC156391
      Conserved Domains (1) summary
      pfam01135
      Location:10206
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    4. NM_001358651.1NP_001345580.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC156391, AK148789, AW494723, BY099821, DV662030
      Conserved Domains (1) summary
      pfam01135
      Location:1190
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    5. NM_001358652.1NP_001345581.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC156391, AK075632, AW494723, BY099821
      Conserved Domains (1) summary
      pfam01135
      Location:1190
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    6. NM_001358653.1NP_001345582.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC156391, AK075632, AW494723, BY099821
      Conserved Domains (1) summary
      pfam01135
      Location:1190
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    7. NM_001358654.1NP_001345583.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC156391, AK075632, AK148789, AW494723, BY099821, DV662030
      Conserved Domains (1) summary
      pfam01135
      Location:1153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    8. NM_001358657.1NP_001345586.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156391, AK075632, AK148789, AW494723, BY099821, DV057407
      Conserved Domains (1) summary
      pfam01135
      Location:1153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    9. NM_008786.3NP_032812.2  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156391, AK075632, AK148789, AW494723, BY099821
      Consensus CDS
      CCDS23687.2
      UniProtKB/TrEMBL
      E9PWE0, Q8BPI6
      Related
      ENSMUSP00000124932.2, ENSMUST00000159917.8
      Conserved Domains (1) summary
      pfam01135
      Location:66274
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      7503609..7557101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313832.2XP_017169321.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X2

      Conserved Domains (1) summary
      pfam01135
      Location:10211
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    2. XM_011243140.3XP_011241442.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X3

      See identical proteins and their annotated locations for XP_011241442.1

      Conserved Domains (1) summary
      pfam01135
      Location:1190
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    3. XM_030244943.1XP_030100803.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X4

      Conserved Domains (1) summary
      pfam01135
      Location:1190
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    4. XM_011243141.4XP_011241443.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X3

      See identical proteins and their annotated locations for XP_011241443.1

      Conserved Domains (1) summary
      pfam01135
      Location:1190
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    5. XM_036155683.1XP_036011576.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X7

      Conserved Domains (1) summary
      pfam01135
      Location:10158
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    6. XM_036155675.1XP_036011568.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X5

      Conserved Domains (1) summary
      pfam01135
      Location:1153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    7. XM_036155676.1XP_036011569.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X5

      Conserved Domains (1) summary
      pfam01135
      Location:1153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    8. XM_036155681.1XP_036011574.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X6

      Conserved Domains (1) summary
      pfam01135
      Location:1153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    9. XM_030244945.1XP_030100805.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X5

      Conserved Domains (1) summary
      pfam01135
      Location:1153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    10. XM_036155679.1XP_036011572.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X5

      Conserved Domains (1) summary
      pfam01135
      Location:1153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    11. XM_030244946.1XP_030100806.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X6

      Conserved Domains (1) summary
      pfam01135
      Location:1153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    12. XM_036155677.1XP_036011570.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X5

      Conserved Domains (1) summary
      pfam01135
      Location:1153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    13. XM_030244947.1XP_030100807.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X6

      Conserved Domains (1) summary
      pfam01135
      Location:1153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    14. XM_036155678.1XP_036011571.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X5

      Conserved Domains (1) summary
      pfam01135
      Location:1153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    15. XM_006512595.5XP_006512658.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X5

      Conserved Domains (1) summary
      pfam01135
      Location:1153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    16. XM_036155680.1XP_036011573.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X6

      Conserved Domains (1) summary
      pfam01135
      Location:1153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    17. XM_036155682.1XP_036011575.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X6

      Conserved Domains (1) summary
      pfam01135
      Location:1153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    18. XM_030244942.1XP_030100802.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X3

      Conserved Domains (1) summary
      pfam01135
      Location:1190
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    19. XM_030244944.1XP_030100804.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X4

      Conserved Domains (1) summary
      pfam01135
      Location:1190
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    20. XM_030244948.1XP_030100808.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X6

      Conserved Domains (1) summary
      pfam01135
      Location:1153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    21. XM_006512589.5XP_006512652.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X1

      Conserved Domains (1) summary
      pfam01135
      Location:66226
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_033219.1: Suppressed sequence

      Description
      NR_033219.1: This RefSeq was removed because the gene was discontinued.
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