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    Pcm1 pericentriolar material 1 [ Mus musculus (house mouse) ]

    Gene ID: 18536, updated on 8-Aug-2021

    Summary

    Official Symbol
    Pcm1provided by MGI
    Official Full Name
    pericentriolar material 1provided by MGI
    Primary source
    MGI:MGI:1277958
    See related
    Ensembl:ENSMUSG00000031592
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2600002H09Rik; 9430077F19Rik; C030044G17Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 13.4), CNS E14 (RPKM 11.0) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pcm1 in Genome Data Viewer
    Location:
    8 A4; 8 23.89 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (41692521..41787125)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (41239484..41334088)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (42325113..42419441)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene fibrinogen-like protein 1 Neighboring gene predicted gene 16348 Neighboring gene N-acylsphingosine amidohydrolase 1 Neighboring gene FSHD region gene 1 Neighboring gene predicted gene, 50494

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC170660

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within interkinetic nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intraciliary transport involved in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intraciliary transport involved in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule anchoring IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule anchoring at centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within microtubule anchoring at centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuronal stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to organelle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary transition zone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    pericentriolar material 1 protein
    Names
    PCM-1
    mPCM-1
    pericentriolar material gene 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023662.3NP_076151.2  pericentriolar material 1 protein

      See identical proteins and their annotated locations for NP_076151.2

      Status: VALIDATED

      Source sequence(s)
      AB029291, AC144926, AK044428, AK052710, AK141516, BM227660, CO043545
      Consensus CDS
      CCDS22261.1
      UniProtKB/Swiss-Prot
      Q9R0L6
      Related
      ENSMUSP00000039709.8, ENSMUST00000045218.9
      Conserved Domains (1) summary
      pfam15717
      Location:13691999
      PCM1_C; Pericentriolar material 1 C terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      41692521..41787125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153815.1XP_036009708.1  pericentriolar material 1 protein isoform X1

      Conserved Domains (1) summary
      pfam15717
      Location:14152045
      PCM1_C; Pericentriolar material 1 C-terminus
    2. XM_036153818.1XP_036009711.1  pericentriolar material 1 protein isoform X6

      Conserved Domains (1) summary
      pfam15717
      Location:14152000
      PCM1_C; Pericentriolar material 1 C-terminus
    3. XM_006509298.3XP_006509361.1  pericentriolar material 1 protein isoform X2

      UniProtKB/Swiss-Prot
      Q9R0L6
      Related
      ENSMUSP00000147887.2, ENSMUST00000211247.2
      Conserved Domains (1) summary
      pfam15717
      Location:14082038
      PCM1_C; Pericentriolar material 1 C-terminus
    4. XM_006509300.3XP_006509363.1  pericentriolar material 1 protein isoform X7

      Conserved Domains (1) summary
      pfam15717
      Location:14081993
      PCM1_C; Pericentriolar material 1 C-terminus
    5. XM_006509301.3XP_006509364.1  pericentriolar material 1 protein isoform X9

      Conserved Domains (2) summary
      COG1196
      Location:229463
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15717
      Location:13531983
      PCM1_C; Pericentriolar material 1 C-terminus
    6. XM_036153819.1XP_036009712.1  pericentriolar material 1 protein isoform X8

      Conserved Domains (2) summary
      COG1196
      Location:229463
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15717
      Location:13571987
      PCM1_C; Pericentriolar material 1 C-terminus
    7. XM_006509302.3XP_006509365.1  pericentriolar material 1 protein isoform X10

      Conserved Domains (2) summary
      COG1196
      Location:229463
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15717
      Location:13501980
      PCM1_C; Pericentriolar material 1 C-terminus
    8. XM_036153817.1XP_036009710.1  pericentriolar material 1 protein isoform X4

      Conserved Domains (1) summary
      pfam15717
      Location:13762006
      PCM1_C; Pericentriolar material 1 C-terminus
    9. XM_036153822.1XP_036009715.1  pericentriolar material 1 protein isoform X13

      Conserved Domains (1) summary
      pfam15717
      Location:13691954
      PCM1_C; Pericentriolar material 1 C-terminus
    10. XM_017312615.3XP_017168104.1  pericentriolar material 1 protein isoform X15

      Conserved Domains (2) summary
      TIGR02302
      Location:231417
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:13141944
      PCM1_C; Pericentriolar material 1 C-terminus
    11. XM_036153823.1XP_036009716.1  pericentriolar material 1 protein isoform X14

      Conserved Domains (1) summary
      pfam15717
      Location:13181948
      PCM1_C; Pericentriolar material 1 C-terminus
    12. XM_036153824.1XP_036009717.1  pericentriolar material 1 protein isoform X16

      Conserved Domains (1) summary
      pfam15717
      Location:13111941
      PCM1_C; Pericentriolar material 1 C-terminus
    13. XM_036153816.1XP_036009709.1  pericentriolar material 1 protein isoform X3

      Conserved Domains (1) summary
      pfam15717
      Location:13822012
      PCM1_C; Pericentriolar material 1 C-terminus
    14. XM_006509299.4XP_006509362.1  pericentriolar material 1 protein isoform X5

      Conserved Domains (1) summary
      pfam15717
      Location:13752005
      PCM1_C; Pericentriolar material 1 C-terminus
    15. XM_036153821.1XP_036009714.1  pericentriolar material 1 protein isoform X12

      Conserved Domains (1) summary
      pfam15717
      Location:13751960
      PCM1_C; Pericentriolar material 1 C-terminus
    16. XM_036153820.1XP_036009713.1  pericentriolar material 1 protein isoform X11

      Conserved Domains (1) summary
      pfam15717
      Location:13431973
      PCM1_C; Pericentriolar material 1 C-terminus
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