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    Pbx2 pre B cell leukemia homeobox 2 [ Mus musculus (house mouse) ]

    Gene ID: 18515, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pbx2provided by MGI
    Official Full Name
    pre B cell leukemia homeobox 2provided by MGI
    Primary source
    MGI:MGI:1341793
    See related
    Ensembl:ENSMUSG00000034673
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G17
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 34.0), limb E14.5 (RPKM 28.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pbx2 in Genome Data Viewer
    Location:
    17; 17 B1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34811233..34816374)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34592259..34597400)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34729416..34734286)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene notch 4 Neighboring gene G-protein signalling modulator 3 (AGS3-like, C. elegans) Neighboring gene advanced glycosylation end product-specific receptor Neighboring gene ring finger protein 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within embryonic limb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryonic organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neuron development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proximal/distal pattern formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    pre-B-cell leukemia transcription factor 2
    Names
    homeobox protein PBX2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017463.3NP_059491.1  pre-B-cell leukemia transcription factor 2

      See identical proteins and their annotated locations for NP_059491.1

      Status: VALIDATED

      Source sequence(s)
      AK159623, CT009767
      Consensus CDS
      CCDS28648.1
      UniProtKB/Swiss-Prot
      O35984
      UniProtKB/TrEMBL
      Q4FJL3
      Related
      ENSMUSP00000040464.7, ENSMUST00000038149.13
      Conserved Domains (2) summary
      cd00086
      Location:245305
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03792
      Location:50243
      PBC; PBC domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34811233..34816374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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