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    Pak1 p21 (RAC1) activated kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18479, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pak1provided by MGI
    Official Full Name
    p21 (RAC1) activated kinase 1provided by MGI
    Primary source
    MGI:MGI:1339975
    See related
    Ensembl:ENSMUSG00000030774 AllianceGenome:MGI:1339975
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Paka; PAK-1
    Summary
    Enables protein serine/threonine kinase activity. Involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within several processes, including nervous system development; neurotransmitter secretion; and observational learning. Located in several cellular components, including dendrite; growth cone; and nucleus. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 87.8), cerebellum adult (RPKM 86.8) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pak1 in Genome Data Viewer
    Location:
    7 E1; 7 53.57 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97437748..97561588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97788541..97912381)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:104870902-104871089 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:104872316-104872580 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:104879154-104879355 Neighboring gene chloride channel, nucleotide-sensitive, 1A Neighboring gene STARR-seq mESC enhancer starr_19606 Neighboring gene aquaporin 11 Neighboring gene STARR-seq mESC enhancer starr_19609 Neighboring gene STARR-seq mESC enhancer starr_19614 Neighboring gene STARR-seq mESC enhancer starr_19615 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene ubiquinol-cytochrome c reductase complex chaperone, CBP3 homolog pseudogene Neighboring gene myosin VIIA Neighboring gene STARR-seq mESC enhancer starr_19616

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables collagen binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables gamma-tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within amygdala development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branching morphogenesis of an epithelial tube ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in branching morphogenesis of an epithelial tube ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within dendrite development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within dendritic spine development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within gamma-aminobutyric acid secretion, neurotransmission IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within glutamate secretion, neurotransmission IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hepatocyte growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell proliferation involved in contact inhibition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell proliferation involved in contact inhibition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within neuromuscular junction development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within observational learning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JUN kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular estrogen receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microtubule nucleation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within receptor clustering IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of long-term synaptic potentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within transmission of nerve impulse IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase PAK 1
    Names
    CDC42/RAC effector kinase PAK-A
    P21 CDKN1A-activated kinase 1
    activated protein kinase alpha
    alpha-PAK
    p21 protein (Cdc42/Rac)-activated kinase 1
    p21-activated kinase 1
    p65-PAK
    NP_001344291.1
    NP_001344292.1
    NP_001344293.1
    NP_001344294.1
    NP_001390408.1
    NP_035165.2
    XP_006507499.1
    XP_006507500.1
    XP_036008662.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357362.2NP_001344291.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: Variants 2 and 6 encode the same isoform (2).
      Source sequence(s)
      AC120438
      UniProtKB/Swiss-Prot
      O88643
      Conserved Domains (2) summary
      cd06654
      Location:256551
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
    2. NM_001357363.2NP_001344292.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 3, 4, and 5 encode the same isoform (1).
      Source sequence(s)
      AC120438
      Consensus CDS
      CCDS21464.1
      UniProtKB/Swiss-Prot
      O88643
      UniProtKB/TrEMBL
      G5E884
      Conserved Domains (2) summary
      cd06654
      Location:248543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    3. NM_001357364.2NP_001344293.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 3, 4, and 5 encode the same isoform (1).
      Source sequence(s)
      AC120438, AC151477
      Consensus CDS
      CCDS21464.1
      UniProtKB/Swiss-Prot
      O88643
      UniProtKB/TrEMBL
      G5E884
      Conserved Domains (2) summary
      cd06654
      Location:248543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    4. NM_001357365.2NP_001344294.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 3, 4, and 5 encode the same isoform (1).
      Source sequence(s)
      AC120438, AC151477
      Consensus CDS
      CCDS21464.1
      UniProtKB/Swiss-Prot
      O88643
      UniProtKB/TrEMBL
      G5E884
      Related
      ENSMUSP00000146055.2, ENSMUST00000206984.2
      Conserved Domains (2) summary
      cd06654
      Location:248543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    5. NM_001403479.1NP_001390408.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: Variants 2 and 6 encode the same isoform (2).
      Source sequence(s)
      AC120438
      UniProtKB/Swiss-Prot
      O88643
    6. NM_011035.3NP_035165.2  serine/threonine-protein kinase PAK 1 isoform 1

      See identical proteins and their annotated locations for NP_035165.2

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 3, 4, and 5 encode the same isoform (1).
      Source sequence(s)
      AC120438
      Consensus CDS
      CCDS21464.1
      UniProtKB/Swiss-Prot
      O88643
      UniProtKB/TrEMBL
      G5E884
      Related
      ENSMUSP00000033040.6, ENSMUST00000033040.12
      Conserved Domains (2) summary
      cd06654
      Location:248543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      97437748..97561588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507436.5XP_006507499.1  serine/threonine-protein kinase PAK 1 isoform X1

      See identical proteins and their annotated locations for XP_006507499.1

      UniProtKB/Swiss-Prot
      O88643
      Conserved Domains (2) summary
      cd06654
      Location:256551
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
    2. XM_036152769.1XP_036008662.1  serine/threonine-protein kinase PAK 1 isoform X2

      UniProtKB/Swiss-Prot
      O88643
      UniProtKB/TrEMBL
      G5E884
      Conserved Domains (2) summary
      cd06654
      Location:248543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    3. XM_006507437.4XP_006507500.1  serine/threonine-protein kinase PAK 1 isoform X1

      See identical proteins and their annotated locations for XP_006507500.1

      UniProtKB/Swiss-Prot
      O88643
      Conserved Domains (2) summary
      cd06654
      Location:256551
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain