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    Pak1 p21 (RAC1) activated kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18479, updated on 5-Sep-2021

    Summary

    Official Symbol
    Pak1provided by MGI
    Official Full Name
    p21 (RAC1) activated kinase 1provided by MGI
    Primary source
    MGI:MGI:1339975
    See related
    Ensembl:ENSMUSG00000030774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; PAK; Paka; PAK-1; AW045634
    Expression
    Biased expression in cortex adult (RPKM 87.8), cerebellum adult (RPKM 86.8) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pak1 in Genome Data Viewer
    Location:
    7 E1; 7 53.57 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97437748..97561588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97788541..97912381)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (104991449..105060891)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene chloride channel, nucleotide-sensitive, 1A Neighboring gene aquaporin 11 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene ubiquinol-cytochrome c reductase complex chaperone, CBP3 homolog pseudogene Neighboring gene myosin VIIA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    contributes_to small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within amygdala development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branching morphogenesis of an epithelial tube ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dendrite development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within dendritic spine development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within gamma-aminobutyric acid secretion, neurotransmission IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within glutamate secretion, neurotransmission IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hepatocyte growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell proliferation involved in contact inhibition ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuromuscular junction development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within observational learning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within receptor clustering IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of long-term synaptic potentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within transmission of nerve impulse IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase PAK 1
    Names
    CDC42/RAC effector kinase PAK-A
    P21 CDKN1A-activated kinase 1
    activated protein kinase alpha
    alpha-PAK
    p21 protein (Cdc42/Rac)-activated kinase 1
    p21-activated kinase 1
    p65-PAK
    NP_001344291.1
    NP_001344292.1
    NP_001344293.1
    NP_001344294.1
    NP_035165.2
    XP_006507499.1
    XP_006507500.1
    XP_011239996.1
    XP_036008662.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357362.1NP_001344291.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC120438
      Conserved Domains (2) summary
      cd06654
      Location:256551
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
    2. NM_001357363.1NP_001344292.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC120438
      Consensus CDS
      CCDS21464.1
      Conserved Domains (2) summary
      cd06654
      Location:248543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    3. NM_001357364.1NP_001344293.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC120438, AC151477
      Consensus CDS
      CCDS21464.1
      Conserved Domains (2) summary
      cd06654
      Location:248543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    4. NM_001357365.1NP_001344294.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC120438, AC151477
      Consensus CDS
      CCDS21464.1
      Related
      ENSMUSP00000146055.2, ENSMUST00000206984.2
      Conserved Domains (2) summary
      cd06654
      Location:248543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    5. NM_011035.2NP_035165.2  serine/threonine-protein kinase PAK 1 isoform 1

      See identical proteins and their annotated locations for NP_035165.2

      Status: VALIDATED

      Source sequence(s)
      AK077497, BC060157, BY630776
      Consensus CDS
      CCDS21464.1
      UniProtKB/TrEMBL
      G5E884
      Related
      ENSMUSP00000033040.6, ENSMUST00000033040.12
      Conserved Domains (2) summary
      cd06654
      Location:248543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      97437748..97561588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507436.5XP_006507499.1  serine/threonine-protein kinase PAK 1 isoform X1

      See identical proteins and their annotated locations for XP_006507499.1

      Conserved Domains (2) summary
      cd06654
      Location:256551
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
    2. XM_036152769.1XP_036008662.1  serine/threonine-protein kinase PAK 1 isoform X2

      Conserved Domains (2) summary
      cd06654
      Location:248543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    3. XM_006507437.4XP_006507500.1  serine/threonine-protein kinase PAK 1 isoform X1

      See identical proteins and their annotated locations for XP_006507500.1

      Conserved Domains (2) summary
      cd06654
      Location:256551
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
    4. XM_011241694.2XP_011239996.1  serine/threonine-protein kinase PAK 1 isoform X1

      See identical proteins and their annotated locations for XP_011239996.1

      Conserved Domains (2) summary
      cd06654
      Location:256551
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74128
      PBD; P21-Rho-binding domain
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