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    Pak1 p21 (RAC1) activated kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18479, updated on 2-Oct-2018

    Summary

    Official Symbol
    Pak1provided by MGI
    Official Full Name
    p21 (RAC1) activated kinase 1provided by MGI
    Primary source
    MGI:MGI:1339975
    See related
    Ensembl:ENSMUSG00000030774 Vega:OTTMUSG00000021135
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Paka; PAK-1; AW045634
    Expression
    Biased expression in cortex adult (RPKM 87.8), cerebellum adult (RPKM 86.8) and 9 other tissues See more
    Orthologs

    Genomic context

    See Pak1 in Genome Data Viewer
    Location:
    7 E1; 7 53.57 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (97830931..97912381)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (104991449..105060891)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene aquaporin 11 Neighboring gene predicted gene, 39050 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene ubiquinol-cytochrome c reductase complex chaperone, CBP3 homolog pseudogene Neighboring gene myosin VIIA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    Rac GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to Rac GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    activation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    amygdala development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    branching morphogenesis of an epithelial tube ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    gamma-aminobutyric acid secretion, neurotransmission IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    glutamate secretion, neurotransmission IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hepatocyte growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation involved in contact inhibition ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular junction development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    observational learning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    receptor clustering IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of long-term synaptic potentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction by protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    stress-activated protein kinase signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    trans-synaptic signaling by endocannabinoid, modulating synaptic transmission EXP
    Inferred from Experiment
    more info
    PubMed 
    trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmission of nerve impulse IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    GABA-ergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    invadopodium ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase PAK 1
    Names
    CDC42/RAC effector kinase PAK-A
    P21 CDKN1A-activated kinase 1
    activated protein kinase alpha
    alpha-PAK
    p21 protein (Cdc42/Rac)-activated kinase 1
    p21-activated kinase 1
    p65-PAK
    NP_035165.2
    XP_006507497.1
    XP_006507499.1
    XP_006507500.1
    XP_011239996.1
    XP_017177517.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357362.1NP_001344291.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC120438
      Conserved Domains (2) summary
      cd06654
      Location:256551
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    2. NM_001357363.1NP_001344292.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC120438
      Conserved Domains (2) summary
      cd06654
      Location:248543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    3. NM_001357364.1NP_001344293.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC120438, AC151477
      Conserved Domains (2) summary
      cd06654
      Location:248543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    4. NM_001357365.1NP_001344294.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC120438, AC151477
      Conserved Domains (2) summary
      cd06654
      Location:248543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    5. NM_011035.2NP_035165.2  serine/threonine-protein kinase PAK 1 isoform 1

      See identical proteins and their annotated locations for NP_035165.2

      Status: VALIDATED

      Source sequence(s)
      AK077497, BC060157, BY630776
      Consensus CDS
      CCDS21464.1
      UniProtKB/TrEMBL
      G5E884
      Related
      ENSMUSP00000033040.5, OTTMUSP00000023295, ENSMUST00000033040.11, OTTMUST00000050033
      Conserved Domains (2) summary
      cd06654
      Location:248543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      97830931..97912381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507436.3XP_006507499.1  serine/threonine-protein kinase PAK 1 isoform X1

      See identical proteins and their annotated locations for XP_006507499.1

      Conserved Domains (2) summary
      cd06654
      Location:256551
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    2. XM_006507437.2XP_006507500.1  serine/threonine-protein kinase PAK 1 isoform X1

      See identical proteins and their annotated locations for XP_006507500.1

      Conserved Domains (2) summary
      cd06654
      Location:256551
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    3. XM_006507434.1XP_006507497.1  serine/threonine-protein kinase PAK 1 isoform X1

      Conserved Domains (2) summary
      cd06654
      Location:256551
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    4. XM_011241694.1XP_011239996.1  serine/threonine-protein kinase PAK 1 isoform X1

      See identical proteins and their annotated locations for XP_011239996.1

      Conserved Domains (2) summary
      cd06654
      Location:256551
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
    5. XM_017322028.1XP_017177517.1  serine/threonine-protein kinase PAK 1 isoform X2

      UniProtKB/TrEMBL
      G5E884
      Conserved Domains (2) summary
      cd06654
      Location:248543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74132
      PBD; P21-Rho-binding domain
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