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    Prdx1 peroxiredoxin 1 [ Mus musculus (house mouse) ]

    Gene ID: 18477, updated on 16-Oct-2021

    Summary

    Official Symbol
    Prdx1provided by MGI
    Official Full Name
    peroxiredoxin 1provided by MGI
    Primary source
    MGI:MGI:99523
    See related
    Ensembl:ENSMUSG00000028691
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAG; OSF3; Paga; PrxI; TDX2; TPxA; prx1; MSP23; NkefA; OSF-3; PrdxI; Tdpx2
    Expression
    Ubiquitous expression in liver E18 (RPKM 260.9), placenta adult (RPKM 195.3) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Prdx1 in Genome Data Viewer
    Location:
    4 D1; 4 53.28 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116542796..116557197)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116685599..116700000)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (116358204..116372605)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member A1 (aldehyde reductase) Neighboring gene predicted gene, 25137 Neighboring gene expressed sequence AV051173 Neighboring gene methylmalonic aciduria cblC type, with homocystinuria Neighboring gene coiled-coil domain containing 163 Neighboring gene testis-specific kinase 2 Neighboring gene target of EGR1, member 1 (nuclear)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antioxidant activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peroxiredoxin activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thioredoxin peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables thioredoxin peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of NIK/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of stress-activated MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in removal of superoxide radicals IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within removal of superoxide radicals IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in myelin sheath HDA PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peroxiredoxin-1
    Names
    Trx dependent peroxide reductase 2
    macrophage 23 Kd stress protein
    macrophage 23 kDa stress protein
    macrophage 23kDa stress protein
    macrophase stress protein 22kDa
    macrophase stress protein 23 kd
    osteoblast-specific factor 3
    proliferation-associated gene A
    thioredoxin peroxidase 2
    thioredoxin-dependent peroxide reductase 2
    thioredoxin-dependent peroxiredoxin 1
    NP_035164.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011034.4NP_035164.1  peroxiredoxin-1

      See identical proteins and their annotated locations for NP_035164.1

      Status: PROVISIONAL

      Source sequence(s)
      AL831786
      Consensus CDS
      CCDS18515.1
      UniProtKB/Swiss-Prot
      P35700
      Related
      ENSMUSP00000114159.2, ENSMUST00000135573.8
      Conserved Domains (1) summary
      cd03015
      Location:8180
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      116542796..116557197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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