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    Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 18472, updated on 14-Oct-2021

    Summary

    Official Symbol
    Pafah1b1provided by MGI
    Official Full Name
    platelet-activating factor acetylhydrolase, isoform 1b, subunit 1provided by MGI
    Primary source
    MGI:MGI:109520
    See related
    Ensembl:ENSMUSG00000020745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lis1; Mdsh; LIS-1; Ms10u; Pafaha; MMS10-U
    Expression
    Ubiquitous expression in CNS E18 (RPKM 47.2), cerebellum adult (RPKM 46.4) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pafah1b1 in Genome Data Viewer
    Location:
    11 B5; 11 45.76 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74564775..74615210, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74673949..74724384, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (74487452..74537886, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 50590 Neighboring gene coiled-coil domain containing 92B Neighboring gene clustered mitochondria (cluA/CLU1) homolog Neighboring gene predicted gene, 24211 Neighboring gene predicted gene, 40198

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC25297

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dynein intermediate chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ameboidal-type cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in auditory receptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brain morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in brain morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebral cortex neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cochlea development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in corpus callosum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of centrosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of planar polarity of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in germ cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within hippocampus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within layer formation in cerebral cortex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within maintenance of centrosome location IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within microtubule cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization involved in establishment of planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule organizing center organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in microtubule organizing center organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nuclear membrane disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within osteoclast development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cellular component organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reelin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retrograde axonal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within retrograde axonal transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in stem cell division ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within transmission of nerve impulse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within vesicle transport along microtubule IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in astral microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in central region of growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    part_of kinesin complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    part_of microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of microtubule associated complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stereocilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    platelet-activating factor acetylhydrolase IB subunit beta
    Names
    PAF acetylhydrolase 45 kDa subunit
    PAF-AH 45 kDa subunit
    PAF-AH alpha
    PAFAH alpha
    Pafaha/Lis1
    lissencephaly-1 protein
    platelet-activating factor acetylhydrolase 1b, regulatory subunit 1
    platelet-activating factor acetylhydrolase 45kD subunit
    platelet-activating factor acetylhydrolase IB subunit alpha
    truncated form platelet-activating factor acetylhydrolase 45kD subunit
    NP_038653.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013625.4NP_038653.1  platelet-activating factor acetylhydrolase IB subunit beta

      See identical proteins and their annotated locations for NP_038653.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes a functional protein.
      Source sequence(s)
      AK144908, AK168929, BE456911, BQ895724
      Consensus CDS
      CCDS25035.1
      UniProtKB/Swiss-Prot
      P63005
      UniProtKB/TrEMBL
      Q5SW18
      Related
      ENSMUSP00000021091.9, ENSMUST00000021091.15
      Conserved Domains (3) summary
      cd00200
      Location:104408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111148
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:1034
      LisH

    RNA

    1. NR_037610.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon and is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK147507, AK160764, AK168929, BE456911

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      74564775..74615210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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