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    Orc2 origin recognition complex, subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 18393, updated on 23-Jun-2021

    Summary

    Official Symbol
    Orc2provided by MGI
    Official Full Name
    origin recognition complex, subunit 2provided by MGI
    Primary source
    MGI:MGI:1328306
    See related
    Ensembl:ENSMUSG00000026037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Or; Orc2l; AU041563
    Expression
    Ubiquitous expression in liver E14 (RPKM 14.2), liver E14.5 (RPKM 11.5) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Orc2 in Genome Data Viewer
    Location:
    1; 1 C1.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58501930..58544268, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58462771..58505113, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (58519615..58561763, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CDC-like kinase 1 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 3 Neighboring gene Ngg1 interacting factor 3-like 1 (S. pombe) Neighboring gene predicted gene, 23966 Neighboring gene predicted gene 15834 Neighboring gene family with sequence similarity 126, member B Neighboring gene NADH:ubiquinone oxidoreductase subunit B3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA replication origin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    part_of inner kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of nuclear origin of replication recognition complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear origin of replication recognition complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of origin recognition complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    origin recognition complex subunit 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025378.2NP_001020549.1  origin recognition complex subunit 2 isoform B

      See identical proteins and their annotated locations for NP_001020549.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) has a shorter 5' UTR and lacks an alternate in-frame exon in the 5' coding region compared to variant a. It encodes isoform B which is shorter than isoform A.
      Source sequence(s)
      AB190256, AC118698, AK048408, BU923423
      Consensus CDS
      CCDS14974.1
      UniProtKB/TrEMBL
      Q543F8, Q59IX1
      Related
      ENSMUSP00000109964.2, ENSMUST00000114325.8
      Conserved Domains (1) summary
      pfam04084
      Location:208513
      ORC2; Origin recognition complex subunit 2
    2. NM_001271526.1NP_001258455.1  origin recognition complex subunit 2 isoform A

      See identical proteins and their annotated locations for NP_001258455.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) uses an alternate splice site in the 5' UTR compared to variant a. Both variants a and c encode the same isoform (A).
      Source sequence(s)
      AC118698, AK048408, AK146859, BU923423
      Consensus CDS
      CCDS14975.1
      UniProtKB/Swiss-Prot
      Q60862
      UniProtKB/TrEMBL
      Q543F8
      Conserved Domains (1) summary
      pfam04084
      Location:255561
      ORC2; Origin recognition complex subunit 2
    3. NM_008765.3NP_032791.1  origin recognition complex subunit 2 isoform A

      See identical proteins and their annotated locations for NP_032791.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (A). Both variants a and c encode the same isoform (A).
      Source sequence(s)
      AC118698, AK048408, BU923423
      Consensus CDS
      CCDS14975.1
      UniProtKB/Swiss-Prot
      Q60862
      UniProtKB/TrEMBL
      Q543F8
      Related
      ENSMUSP00000027198.6, ENSMUST00000027198.12
      Conserved Domains (1) summary
      pfam04084
      Location:255561
      ORC2; Origin recognition complex subunit 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      58501930..58544268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252150.2XP_030108010.1  origin recognition complex subunit 2 isoform X1

      Conserved Domains (1) summary
      pfam04084
      Location:208513
      ORC2; Origin recognition complex subunit 2
    2. XM_011238453.4XP_011236755.1  origin recognition complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_011236755.1

      UniProtKB/TrEMBL
      Q59IX1
      Conserved Domains (1) summary
      pfam04084
      Location:208513
      ORC2; Origin recognition complex subunit 2
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