Format

Send to:

Choose Destination
    • Showing Current items.

    Sigmar1 sigma non-opioid intracellular receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 18391, updated on 26-Oct-2021

    Summary

    Official Symbol
    Sigmar1provided by MGI
    Official Full Name
    sigma non-opioid intracellular receptor 1provided by MGI
    Primary source
    MGI:MGI:1195268
    See related
    Ensembl:ENSMUSG00000036078
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oprs1; Sig1R; sigma1R
    Summary
    This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]
    Expression
    Ubiquitous expression in liver adult (RPKM 37.0), subcutaneous fat pad adult (RPKM 22.3) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sigmar1 in Genome Data Viewer
    Location:
    4; 4 A5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41738493..41741359, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41738493..41741359, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (41685369..41688186, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene dynactin 3 Neighboring gene AT rich interactive domain 3C (BRIGHT-like) Neighboring gene predicted gene, 42274 Neighboring gene galactose-1-phosphate uridyl transferase Neighboring gene interleukin 11 receptor, alpha chain 1 Neighboring gene chemokine (C-C motif) ligand 27A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled opioid receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell death in response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotrimerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sigma non-opioid intracellular receptor 1
    Names
    opioid receptor, sigma 1
    sigma 1 receptor variant SR-1D
    sigma 1-type opioid receptor
    sigma1-receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286538.1NP_001273467.1  sigma non-opioid intracellular receptor 1 isoform 2

      See identical proteins and their annotated locations for NP_001273467.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site in the 3' terminal exon which results in a frameshift compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF030198, AY390765, BB741155, BB851853
      UniProtKB/Swiss-Prot
      O55242
      UniProtKB/TrEMBL
      B7ZJH6
      Conserved Domains (1) summary
      pfam04622
      Location:13148
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
    2. NM_001286539.1NP_001273468.1  sigma non-opioid intracellular receptor 1 isoform 3

      See identical proteins and their annotated locations for NP_001273468.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
      Source sequence(s)
      AF030198, AY390764, BB741155, BB851853
      Consensus CDS
      CCDS71362.1
      UniProtKB/Swiss-Prot
      O55242
      UniProtKB/TrEMBL
      A2AMS0
      Related
      ENSMUSP00000071492.7, ENSMUST00000071561.7
      Conserved Domains (1) summary
      pfam04622
      Location:13183
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
    3. NM_001286540.1NP_001273469.1  sigma non-opioid intracellular receptor 1 isoform 4

      See identical proteins and their annotated locations for NP_001273469.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' terminal exon compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1.
      Source sequence(s)
      AF030198, AY390766, BB741155, BB851853
      UniProtKB/Swiss-Prot
      O55242
      UniProtKB/TrEMBL
      B7ZJH7
      Conserved Domains (1) summary
      pfam04622
      Location:13176
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
    4. NM_001286541.1NP_001273470.1  sigma non-opioid intracellular receptor 1 isoform 5

      See identical proteins and their annotated locations for NP_001273470.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded protein (isoform 5) is shorter than isoform 1.
      Source sequence(s)
      AF030198, AY390768, BB741155, BB851853
      UniProtKB/Swiss-Prot
      O55242
      UniProtKB/TrEMBL
      B7ZJH9
      Conserved Domains (1) summary
      pfam04622
      Location:51147
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
    5. NM_001286542.1NP_001273471.1  sigma non-opioid intracellular receptor 1 isoform 6

      See identical proteins and their annotated locations for NP_001273471.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The encoded protein (isoform 6) is shorter than isoform 1.
      Source sequence(s)
      AL807796
      UniProtKB/TrEMBL
      B7ZJH8
      Conserved Domains (1) summary
      pfam04622
      Location:36105
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
    6. NM_001286551.1NP_001273480.1  sigma non-opioid intracellular receptor 1 isoform 7

      See identical proteins and their annotated locations for NP_001273480.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 3' UTR and uses an alternate splice site in the coding region which results in a frameshift compared to variant 1. The encoded protein (isoform 7; also known as short form sigma1R) is shorter and has a distinct C-terminus compared to isoform 1. This isoform negatively regulates the function of the longest isoform (1) by forming a complex with the latter (PMID 22619170). Variants 7 and 8 encode the same protein.
      Source sequence(s)
      AF030198, BB741155, BB851853, BM507398
      UniProtKB/Swiss-Prot
      O55242
      UniProtKB/TrEMBL
      I4DCY6
      Conserved Domains (1) summary
      pfam04622
      Location:13102
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
    7. NM_001286605.1NP_001273534.1  sigma non-opioid intracellular receptor 1 isoform 7

      See identical proteins and their annotated locations for NP_001273534.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 3' UTR and uses an alternate splice site in the coding region which results in a frameshift compared to variant 1. The encoded protein (isoform 7; also known as short form sigma1R) is shorter and has a distinct C-terminus compared to isoform 1. Variants 7 and 8 encode the same protein.
      Source sequence(s)
      AL807796
      UniProtKB/TrEMBL
      I4DCY6
      Conserved Domains (1) summary
      pfam04622
      Location:13102
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein
    8. NM_011014.3NP_035144.1  sigma non-opioid intracellular receptor 1 isoform 1

      See identical proteins and their annotated locations for NP_035144.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF030198, BB741155, BB851853
      Consensus CDS
      CCDS18070.1
      UniProtKB/Swiss-Prot
      O55242
      Related
      ENSMUSP00000056027.8, ENSMUST00000059354.15
      Conserved Domains (1) summary
      pfam04622
      Location:13214
      ERG2_Sigma1R; ERG2 and Sigma1 receptor like protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      41738493..41741359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center