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    Odf2 outer dense fiber of sperm tails 2 [ Mus musculus (house mouse) ]

    Gene ID: 18286, updated on 26-Sep-2022

    Summary

    Official Symbol
    Odf2provided by MGI
    Official Full Name
    outer dense fiber of sperm tails 2provided by MGI
    Primary source
    MGI:MGI:1098824
    See related
    Ensembl:ENSMUSG00000026790 AllianceGenome:MGI:1098824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MMTEST29
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in several processes, including centriole-centriole cohesion; cilium organization; and regulation of cilium assembly. Predicted to act upstream of or within cell differentiation and spermatogenesis. Located in centriole; centrosome; and sperm flagellum. Part of ciliary transition fiber. Is expressed in several structures, including early conceptus; inner ear; liver; reproductive system; and stomach. Orthologous to human ODF2 (outer dense fiber of sperm tails 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 224.3), cerebellum adult (RPKM 22.9) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Odf2 in Genome Data Viewer
    Location:
    2 B; 2 20.79 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29779026..29821758)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (29889014..29931746)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene microRNA 219a-2 Neighboring gene predicted gene, 54109 Neighboring gene microRNA 219b Neighboring gene cerebral endothelial cell adhesion molecule Neighboring gene RIKEN cDNA 2600006K01 gene Neighboring gene GLE1 RNA export mediator (yeast) Neighboring gene spectrin alpha, non-erythrocytic 1 Neighboring gene microRNA 6997

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    part_of centriolar subdistal appendage ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ciliary transition fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in outer dense fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    outer dense fiber protein 2
    Names
    84 kDa outer dense fiber protein
    cenexin
    outer dense fiber of sperm tails protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113213.2NP_001106684.1  outer dense fiber protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses a different splice site, compared to variant 4. The resulting protein (isoform a) is shorter by 1 aa when it is compared to isoform d. Variants 1 and 6 both encode the same isoform (a).
      Source sequence(s)
      AL928926
      Consensus CDS
      CCDS50556.1
      UniProtKB/Swiss-Prot
      A3KGV1
      UniProtKB/TrEMBL
      A0A6P7QU81, Q3UFG2
      Related
      ENSMUSP00000109385.2, ENSMUST00000113756.8
      Conserved Domains (1) summary
      COG1196
      Location:114802
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    2. NM_001113214.2NP_001106685.1  outer dense fiber protein 2 isoform b

      See identical proteins and their annotated locations for NP_001106685.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site and contains a different 3' end, compared to variant 4. The resulting protein (isoform b) has a shorter and distinct C-terminus when it is compared to isoform d. Variants 2 and 7 both encode the same isoform (a).
      Source sequence(s)
      AL928926
      Consensus CDS
      CCDS50557.1
      UniProtKB/Swiss-Prot
      A3KGV1
      Related
      ENSMUSP00000109384.2, ENSMUST00000113755.8
      Conserved Domains (1) summary
      COG1196
      Location:114446
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    3. NM_001177659.2NP_001171130.1  outer dense fiber protein 2 isoform d

      See identical proteins and their annotated locations for NP_001171130.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes isoform d.
      Source sequence(s)
      AL928926
      Consensus CDS
      CCDS50555.1
      UniProtKB/Swiss-Prot
      A3KGV1
      UniProtKB/TrEMBL
      A0A6P7QU73
      Related
      ENSMUSP00000109388.3, ENSMUST00000113759.9
      Conserved Domains (1) summary
      COG1196
      Location:114803
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    4. NM_001177661.2NP_001171132.1  outer dense fiber protein 2 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences that result in a different splice site and distinct 5' and 3' ends, compared to variant 4. The encoded protein (isoform c) has shorter and distinct termini when it is compared to isoform e.
      Source sequence(s)
      AL928926
      Consensus CDS
      CCDS50554.1
      UniProtKB/Swiss-Prot
      A3KGV1
      UniProtKB/TrEMBL
      A0A8C6GSJ6, A3KGW0
      Related
      ENSMUSP00000109396.2, ENSMUST00000113767.8
      Conserved Domains (1) summary
      cl25732
      Location:163495
      SMC_N; RecF/RecN/SMC N terminal domain
    5. NM_001355136.2NP_001342065.1  outer dense fiber protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 1, encodes isoform a.
      Source sequence(s)
      AL928926
      Consensus CDS
      CCDS50556.1
      UniProtKB/TrEMBL
      A0A6P7QU81
      Related
      ENSMUSP00000049272.8, ENSMUST00000046571.14
      Conserved Domains (1) summary
      COG1196
      Location:114802
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    6. NM_001355137.2NP_001342066.1  outer dense fiber protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 2, encodes isoform b.
      Source sequence(s)
      AL928926
      Consensus CDS
      CCDS50557.1
      Conserved Domains (1) summary
      COG1196
      Location:114446
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    7. NM_001355138.2NP_001342067.1  outer dense fiber protein 2 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL928926
      Conserved Domains (1) summary
      cl25732
      Location:95427
      SMC_N; RecF/RecN/SMC N terminal domain
    8. NM_001369060.2NP_001355989.1  outer dense fiber protein 2 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), encodes the longest isoform (g).
      Source sequence(s)
      AL928926
      Consensus CDS
      CCDS89461.1
      UniProtKB/Swiss-Prot
      Q6PGI6
      UniProtKB/TrEMBL
      A0A6P7QJT4
      Related
      ENSMUSP00000109394.2, ENSMUST00000113765.8
      Conserved Domains (1) summary
      COG1196
      Location:119807
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    9. NM_001374179.1NP_001361108.1  outer dense fiber protein 2 isoform h

      Status: VALIDATED

      Source sequence(s)
      AL928926
      Conserved Domains (1) summary
      COG1196
      Location:72760
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    10. NM_001374180.1NP_001361109.1  outer dense fiber protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL928926
      Consensus CDS
      CCDS50556.1
      UniProtKB/TrEMBL
      A0A6P7QU81
      Related
      ENSMUSP00000139390.2, ENSMUST00000184845.8
      Conserved Domains (1) summary
      COG1196
      Location:114802
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    11. NM_001374181.1NP_001361110.1  outer dense fiber protein 2 isoform i

      Status: VALIDATED

      Source sequence(s)
      AL928926
      Consensus CDS
      CCDS89462.1
      UniProtKB/TrEMBL
      A0A6P7QX38
      Conserved Domains (1) summary
      COG1196
      Location:95783
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    12. NM_001374182.1NP_001361111.1  outer dense fiber protein 2 isoform i

      Status: VALIDATED

      Source sequence(s)
      AL928926
      Consensus CDS
      CCDS89462.1
      UniProtKB/TrEMBL
      A0A6P7QX38
      Related
      ENSMUSP00000109386.2, ENSMUST00000113757.8
      Conserved Domains (1) summary
      COG1196
      Location:95783
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    13. NM_013615.4NP_038643.1  outer dense fiber protein 2 isoform c

      See identical proteins and their annotated locations for NP_038643.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences that result in a different splice site and distinct 5' and 3' ends, compared to variant 4. The encoded protein (isoform c) has shorter and distinct termini when it is compared to isoform d.
      Source sequence(s)
      AL928926
      Consensus CDS
      CCDS15861.1
      UniProtKB/Swiss-Prot
      A3KGV1
      Related
      ENSMUSP00000028128.7, ENSMUST00000028128.13
      Conserved Domains (1) summary
      cl25732
      Location:100432
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      29779026..29821758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316279.2XP_017171768.1  outer dense fiber protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A6P7QWZ6
      Conserved Domains (1) summary
      COG1196
      Location:120809
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    2. XM_036159407.1XP_036015300.1  outer dense fiber protein 2 isoform X5

      Conserved Domains (1) summary
      COG1196
      Location:120808
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    3. XM_030248314.1XP_030104174.1  outer dense fiber protein 2 isoform X9

      Conserved Domains (1) summary
      COG1196
      Location:101789
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    4. XM_017316291.1XP_017171780.1  outer dense fiber protein 2 isoform X7

      UniProtKB/Swiss-Prot
      A3KGV1
      UniProtKB/TrEMBL
      A0A6P7QU73
      Conserved Domains (1) summary
      COG1196
      Location:114803
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    5. XM_017316301.1XP_017171790.1  outer dense fiber protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A6P7QU92
      Conserved Domains (1) summary
      COG1196
      Location:95784
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    6. XM_036159440.1XP_036015333.1  outer dense fiber protein 2 isoform X13

      UniProtKB/TrEMBL
      A0A6P7QX38
      Conserved Domains (1) summary
      COG1196
      Location:95783
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    7. XM_036159428.1XP_036015321.1  outer dense fiber protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A6P7QU81
      Conserved Domains (1) summary
      COG1196
      Location:114802
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    8. XM_017316304.1XP_017171793.1  outer dense fiber protein 2 isoform X13

      UniProtKB/Swiss-Prot
      A3KGV1
      UniProtKB/TrEMBL
      A0A6P7QX38
      Conserved Domains (1) summary
      COG1196
      Location:95783
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    9. XM_017316272.3XP_017171761.1  outer dense fiber protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A6P5P4V3
      Conserved Domains (1) summary
      COG1196
      Location:163852
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    10. XM_017316275.3XP_017171764.1  outer dense fiber protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A6P7QWY7
      Conserved Domains (1) summary
      COG1196
      Location:144833
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    11. XM_017316276.3XP_017171765.1  outer dense fiber protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A6P7QLD4
      Conserved Domains (1) summary
      COG1196
      Location:144832
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    12. XM_017316300.2XP_017171789.1  outer dense fiber protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A6P7QU92
      Conserved Domains (1) summary
      COG1196
      Location:95784
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    13. XM_036159427.1XP_036015320.1  outer dense fiber protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A6P7QU81
      Conserved Domains (1) summary
      COG1196
      Location:114802
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    14. XM_017316295.3XP_017171784.1  outer dense fiber protein 2 isoform X10

      Conserved Domains (1) summary
      COG1196
      Location:100789
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    15. XM_030248309.2XP_030104169.1  outer dense fiber protein 2 isoform X6

      UniProtKB/Swiss-Prot
      Q6PGI6
      UniProtKB/TrEMBL
      A0A6P7QJT4
      Conserved Domains (1) summary
      COG1196
      Location:119807
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    16. XM_017316292.2XP_017171781.1  outer dense fiber protein 2 isoform X7

      UniProtKB/Swiss-Prot
      A3KGV1
      UniProtKB/TrEMBL
      A0A6P7QU73
      Conserved Domains (1) summary
      COG1196
      Location:114803
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    17. XM_036159437.1XP_036015330.1  outer dense fiber protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A6P7QU92
      Conserved Domains (1) summary
      COG1196
      Location:95784
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    18. XM_036159412.1XP_036015305.1  outer dense fiber protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A6P7QU73
      Conserved Domains (1) summary
      COG1196
      Location:114803
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    19. XM_017316290.3XP_017171779.1  outer dense fiber protein 2 isoform X7

      UniProtKB/Swiss-Prot
      A3KGV1
      UniProtKB/TrEMBL
      A0A6P7QU73
      Conserved Domains (1) summary
      COG1196
      Location:114803
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    20. XM_017316294.3XP_017171783.1  outer dense fiber protein 2 isoform X10

      Conserved Domains (1) summary
      COG1196
      Location:100789
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    21. XM_017316293.3XP_017171782.1  outer dense fiber protein 2 isoform X8

      UniProtKB/Swiss-Prot
      A3KGV1
      UniProtKB/TrEMBL
      A0A6P7QU81
      Conserved Domains (1) summary
      COG1196
      Location:114802
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    22. XM_017316299.3XP_017171788.1  outer dense fiber protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A6P7QJU6
      Conserved Domains (1) summary
      COG1196
      Location:100788
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    23. XM_036159408.1XP_036015301.1  outer dense fiber protein 2 isoform X6

      UniProtKB/Swiss-Prot
      Q6PGI6
      UniProtKB/TrEMBL
      A0A6P7QJT4
      Conserved Domains (1) summary
      COG1196
      Location:119807
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_003951351.2 RNA Sequence

    2. XR_003951352.2 RNA Sequence

    3. XR_003951350.2 RNA Sequence