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    Ocln occludin [ Mus musculus (house mouse) ]

    Gene ID: 18260, updated on 18-Sep-2024

    Summary

    Official Symbol
    Oclnprovided by MGI
    Official Full Name
    occludinprovided by MGI
    Primary source
    MGI:MGI:106183
    See related
    Ensembl:ENSMUSG00000021638 AllianceGenome:MGI:106183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ocl
    Summary
    Predicted to enable protein domain specific binding activity. Involved in negative regulation of gene expression and tight junction organization. Located in several cellular components, including apical plasma membrane; apicolateral plasma membrane; and bicellular tight junction. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in large intestine adult (RPKM 9.2), colon adult (RPKM 5.6) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Ocln in Genome Data Viewer
    Location:
    13 D1; 13 53.23 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100633012..100689226, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100496504..100552718, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31, pseudogene 13 Neighboring gene NLR family, apoptosis inhibitory protein 1 Neighboring gene general transcription factor II H, polypeptide 2 Neighboring gene STARR-positive B cell enhancer ABC_E1467 Neighboring gene predicted gene, 57598 Neighboring gene eukaryotic translation initiation factor 4, gamma 1 pseudogene Neighboring gene MARVEL (membrane-associating) domain containing 2 Neighboring gene predicted gene, 24261

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bicellular tight junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell-cell junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of D-glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of D-glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood-brain barrier permeability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood-brain barrier permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to interleukin-18 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tight junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in tight junction ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    occludin
    NP_001347465.1
    NP_001347466.1
    NP_001347467.1
    NP_001347468.1
    NP_032782.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360536.1NP_001347465.1  occludin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158536
      Consensus CDS
      CCDS26731.1
      UniProtKB/Swiss-Prot
      Q544A7, Q61146
      UniProtKB/TrEMBL
      B2RS24
      Related
      ENSMUSP00000022140.6, ENSMUST00000022140.12
      Conserved Domains (2) summary
      pfam01284
      Location:57261
      MARVEL; Membrane-associating domain
      pfam07303
      Location:419518
      Occludin_ELL; Occludin homology domain
    2. NM_001360537.1NP_001347466.1  occludin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158536
      Consensus CDS
      CCDS26731.1
      UniProtKB/Swiss-Prot
      Q544A7, Q61146
      UniProtKB/TrEMBL
      B2RS24
      Related
      ENSMUSP00000124849.2, ENSMUST00000160859.8
      Conserved Domains (2) summary
      pfam01284
      Location:57261
      MARVEL; Membrane-associating domain
      pfam07303
      Location:419518
      Occludin_ELL; Occludin homology domain
    3. NM_001360538.1NP_001347467.1  occludin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158536
      Consensus CDS
      CCDS26731.1
      UniProtKB/Swiss-Prot
      Q544A7, Q61146
      UniProtKB/TrEMBL
      B2RS24
      Conserved Domains (2) summary
      pfam01284
      Location:57261
      MARVEL; Membrane-associating domain
      pfam07303
      Location:419518
      Occludin_ELL; Occludin homology domain
    4. NM_001360539.1NP_001347468.1  occludin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158536
      UniProtKB/TrEMBL
      Q3UKZ5
      Related
      ENSMUSP00000125642.2, ENSMUST00000159459.8
      Conserved Domains (1) summary
      pfam07303
      Location:225324
      Occludin_ELL; Occludin homology domain
    5. NM_008756.2NP_032782.1  occludin isoform 1

      See identical proteins and their annotated locations for NP_032782.1

      Status: VALIDATED

      Source sequence(s)
      AK042576
      Consensus CDS
      CCDS26731.1
      UniProtKB/Swiss-Prot
      Q544A7, Q61146
      UniProtKB/TrEMBL
      B2RS24
      Related
      ENSMUSP00000065284.5, ENSMUST00000069756.11
      Conserved Domains (2) summary
      pfam01284
      Location:57261
      MARVEL; Membrane-associating domain
      pfam07303
      Location:419518
      Occludin_ELL; Occludin homology domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      100633012..100689226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)