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    Oaz2 ornithine decarboxylase antizyme 2 [ Mus musculus (house mouse) ]

    Gene ID: 18247, updated on 6-Jun-2024


    Official Symbol
    Oaz2provided by MGI
    Official Full Name
    ornithine decarboxylase antizyme 2provided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000040652 AllianceGenome:MGI:109492
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AZ2; AZ-2; Sez15; Oaz2-ps
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
    Ubiquitous expression in lung adult (RPKM 83.1), CNS E18 (RPKM 58.2) and 28 other tissues See more
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    Genomic context

    See Oaz2 in Genome Data Viewer
    9 C; 9 35.45 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65583830..65597582)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65676548..65690300)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24463 Neighboring gene STARR-seq mESC enhancer starr_24464 Neighboring gene predicted pseudogene 10144 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65469333-65469516 Neighboring gene STARR-seq mESC enhancer starr_24467 Neighboring gene RNA binding protein with multiple splicing 2 Neighboring gene STARR-positive B cell enhancer ABC_E9768 Neighboring gene STARR-seq mESC enhancer starr_24469 Neighboring gene zinc finger protein 609 Neighboring gene STARR-seq mESC enhancer starr_24471 Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Pathways from PubChem

    General gene information


    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ornithine decarboxylase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    enables ornithine decarboxylase inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    enables ornithine decarboxylase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info

    General protein information

    Preferred Names
    ornithine decarboxylase antizyme 2
    ODC-Az 2
    antizyme 2
    seizure-related protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301307.1NP_001288236.1  ornithine decarboxylase antizyme 2 isoform 2

      Status: REVIEWED

      Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK169243, BC083114, CJ072367
      Conserved Domains (1) summary
      ODC_AZ; Ornithine decarboxylase antizyme
    2. NM_010952.3NP_035082.1  ornithine decarboxylase antizyme 2 isoform 1

      See identical proteins and their annotated locations for NP_035082.1

      Status: REVIEWED

      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK169243, BC083114
      Consensus CDS
      ENSMUSP00000136914.2, ENSMUST00000153700.9
      Conserved Domains (1) summary
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000075.7 Reference GRCm39 C57BL/6J

      GenBank, FASTA, Sequence Viewer (Graphics)