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    Oaz2 ornithine decarboxylase antizyme 2 [ Mus musculus (house mouse) ]

    Gene ID: 18247, updated on 23-May-2018

    Summary

    Official Symbol
    Oaz2provided by MGI
    Official Full Name
    ornithine decarboxylase antizyme 2provided by MGI
    Primary source
    MGI:MGI:109492
    See related
    Ensembl:ENSMUSG00000040652 Vega:OTTMUSG00000031899
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AZ2; AZ-2; Sez15; Oaz2-ps
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in lung adult (RPKM 83.1), CNS E18 (RPKM 58.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Oaz2 in Genome Data Viewer
    Location:
    9; 9 C
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (65676548..65690300)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (65524355..65538107)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 10144 Neighboring gene RNA binding protein with multiple splicing 2 Neighboring gene zinc finger protein 609 Neighboring gene predicted gene, 30089 Neighboring gene predicted gene, 30314 Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ornithine decarboxylase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ornithine decarboxylase inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ornithine decarboxylase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ornithine decarboxylase antizyme 2
    Names
    ODC-Az 2
    antizyme 2
    seizure-related protein 15

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301307.1NP_001288236.1  ornithine decarboxylase antizyme 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK169243, BC083114, CJ072367
      Conserved Domains (1) summary
      pfam02100
      Location:97180
      ODC_AZ; Ornithine decarboxylase antizyme
    2. NM_010952.3NP_035082.1  ornithine decarboxylase antizyme 2 isoform 1

      See identical proteins and their annotated locations for NP_035082.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK169243, BC083114
      Consensus CDS
      CCDS57683.1
      UniProtKB/Swiss-Prot
      O08608
      Related
      ENSMUSP00000136914.1, OTTMUSP00000062513, ENSMUST00000153700.8, OTTMUST00000079080
      Conserved Domains (1) summary
      pfam02100
      Location:98181
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      65676548..65690300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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