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    Nup62 nucleoporin 62 [ Mus musculus (house mouse) ]

    Gene ID: 18226, updated on 19-Jul-2021

    Summary

    Official Symbol
    Nup62provided by MGI
    Official Full Name
    nucleoporin 62provided by MGI
    Primary source
    MGI:MGI:1351500
    See related
    Ensembl:ENSMUSG00000109511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p6; Nup; p62; Nupc1; D7Ertd649; D7Ertd649e
    Expression
    Ubiquitous expression in testis adult (RPKM 53.2), thymus adult (RPKM 44.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nup62 in Genome Data Viewer
    Location:
    7 B3; 7 28.93 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44465512..44481260)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44816088..44831836)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (52071790..52086177)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vaccinia related kinase 3 Neighboring gene predicted gene, 29791 Neighboring gene activating transcription factor 5 Neighboring gene interleukin 4 induced 1B Neighboring gene interleukin 4 induced 1 Neighboring gene TBC1 domain family, member 17 Neighboring gene AKT1 substrate 1 (proline-rich) Neighboring gene microRNA 707

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough Il4i1b

    Readthrough gene: Il4i1b, Included gene: Il4i1

    Homology

    Clone Names

    • MGC101995

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables PTB domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor complex adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centriole assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic centrosome separation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cytokinetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Flemming body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in annulate lamellae ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear pore glycoprotein p62
    Names
    62 kDa nucleoporin
    nuclear pore complex 1
    nucleoporin Nup62

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053074.2NP_444304.1  nuclear pore glycoprotein p62

      See identical proteins and their annotated locations for NP_444304.1

      Status: VALIDATED

      Source sequence(s)
      AC158231, AK171611
      Consensus CDS
      CCDS21216.1
      UniProtKB/Swiss-Prot
      Q63850
      UniProtKB/TrEMBL
      Q5FWJ9
      Related
      ENSMUSP00000056785.10, ENSMUST00000057195.17
      Conserved Domains (2) summary
      pfam05064
      Location:318433
      Nsp1_C; Nsp1-like C-terminal region
      pfam16043
      Location:366505
      DUF4795; Domain of unknown function (DUF4795)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44465512..44481260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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