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    Nudc nudC nuclear distribution protein [ Mus musculus (house mouse) ]

    Gene ID: 18221, updated on 26-Sep-2022

    Summary

    Official Symbol
    Nudcprovided by MGI
    Official Full Name
    nudC nuclear distribution proteinprovided by MGI
    Primary source
    MGI:MGI:106014
    See related
    Ensembl:ENSMUSG00000028851 AllianceGenome:MGI:106014
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SIG-92; Silg92
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in several processes, including mitotic metaphase plate congression; mitotic spindle organization; and nuclear migration. Predicted to act upstream of or within cell division. Predicted to be located in several cellular components, including Golgi apparatus; midbody; and mitotic spindle. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human NUDC (nuclear distribution C, dynein complex regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 117.1), liver E14 (RPKM 77.3) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Nudc in Genome Data Viewer
    Location:
    4; 4 D2.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133259853..133273338, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133532542..133546027, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene TMF1-regulated nuclear protein 1 Neighboring gene predicted gene, 42323 Neighboring gene keratinocyte differentiation factor 1 Neighboring gene nuclear receptor subfamily 0, group B, member 2 Neighboring gene G patch domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nuclear migration protein nudC
    Names
    nuclear distribution gene C homolog
    nuclear distribution protein C homolog
    silica-induced gene 92 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010948.3NP_035078.1  nuclear migration protein nudC

      See identical proteins and their annotated locations for NP_035078.1

      Status: VALIDATED

      Source sequence(s)
      AK032673, BE948227, DV652222
      Consensus CDS
      CCDS18750.1
      UniProtKB/Swiss-Prot
      O35685, Q3UJS7
      Related
      ENSMUSP00000030665.7, ENSMUST00000030665.7
      Conserved Domains (3) summary
      cd06492
      Location:173259
      p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...
      pfam14050
      Location:960
      Nudc_N; N-terminal conserved domain of Nudc
      pfam16273
      Location:98144
      NuDC; Nuclear distribution C domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      133259853..133273338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)