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    Nucb1 nucleobindin 1 [ Mus musculus (house mouse) ]

    Gene ID: 18220, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nucb1provided by MGI
    Official Full Name
    nucleobindin 1provided by MGI
    Primary source
    MGI:MGI:97388
    See related
    Ensembl:ENSMUSG00000030824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cal; Nucb; C77483; Calnuc; MTEST8; MTEST82; B230337F23Rik
    Expression
    Ubiquitous expression in colon adult (RPKM 160.1), genital fat pad adult (RPKM 128.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nucb1 in Genome Data Viewer
    Location:
    7; 7 B3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45142098..45159832, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45492674..45510408, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (52748044..52765778, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene BCL2-associated X protein Neighboring gene dihydrodiol dehydrogenase (dimeric) Neighboring gene tubby-like protein 2 Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 Neighboring gene predicted gene, 53387

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of protein targeting ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi cisterna membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi-associated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lumenal side of Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163662.1NP_001157134.1  nucleobindin-1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001157134.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC151602, AK140710, AK160981
      Consensus CDS
      CCDS52247.1
      UniProtKB/Swiss-Prot
      Q02819
      Related
      ENSMUSP00000147383.2, ENSMUST00000211765.2
      Conserved Domains (1) summary
      pfam13499
      Location:245318
      EF-hand_7; EF-hand domain pair
    2. NM_008749.2NP_032775.1  nucleobindin-1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_032775.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AC151602, AK140710, AK160981
      Consensus CDS
      CCDS85300.1
      UniProtKB/Swiss-Prot
      Q02819
      UniProtKB/TrEMBL
      A0A1C7CYU3
      Related
      ENSMUSP00000033096.9, ENSMUST00000033096.16
      Conserved Domains (1) summary
      pfam13499
      Location:245318
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45142098..45159832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540696.4XP_006540759.1  nucleobindin-1 isoform X1

      See identical proteins and their annotated locations for XP_006540759.1

      UniProtKB/Swiss-Prot
      Q02819
      Conserved Domains (1) summary
      pfam13499
      Location:245318
      EF-hand_7; EF-hand domain pair
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