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    Nsf N-ethylmaleimide sensitive fusion protein [ Mus musculus (house mouse) ]

    Gene ID: 18195, updated on 4-Nov-2018

    Summary

    Official Symbol
    Nsfprovided by MGI
    Official Full Name
    N-ethylmaleimide sensitive fusion proteinprovided by MGI
    Primary source
    MGI:MGI:104560
    See related
    Ensembl:ENSMUSG00000034187 Vega:OTTMUSG00000003022
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SKD2; AI316878; AU020090; AU067812
    Expression
    Broad expression in cerebellum adult (RPKM 105.1), frontal lobe adult (RPKM 99.1) and 21 other tissues See more
    Orthologs

    Genomic context

    See Nsf in Genome Data Viewer
    Location:
    11 E1; 11 67.54 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (103821782..103954056, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (103683096..103815370, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene wingless-type MMTV integration site family, member 9B Neighboring gene wingless-type MMTV integration site family, member 3 Neighboring gene predicted gene, 35365 Neighboring gene predicted gene, 35311 Neighboring gene predicted gene 8738 Neighboring gene ADP-ribosylation factor 2 Neighboring gene predicted gene, 39399

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase activity, coupled IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    D1 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rab GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    syntaxin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    syntaxin-1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi stack IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi stack ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    vesicle-fusing ATPase
    Names
    N-ethylmaleimide sensitive factor
    NEM-sensitive fusion protein
    suppressor of K(+) transport growth defect 2
    vesicular-fusion protein NSF
    NP_032766.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008740.4NP_032766.2  vesicle-fusing ATPase

      See identical proteins and their annotated locations for NP_032766.2

      Status: VALIDATED

      Source sequence(s)
      AL596108, AL603829
      Consensus CDS
      CCDS25524.1
      UniProtKB/Swiss-Prot
      P46460
      Related
      ENSMUSP00000099364.4, OTTMUSP00000002926, ENSMUST00000103075.10, OTTMUST00000006200
      Conserved Domains (4) summary
      smart00382
      Location:254399
      AAA; ATPases associated with a variety of cellular activities
      smart01072
      Location:111183
      CDC48_2; Cell division protein 48 (CDC48) domain 2
      smart01073
      Location:683
      CDC48_N; Cell division protein 48 (CDC48) N-terminal domain
      pfam00004
      Location:256397
      AAA; ATPase family associated with various cellular activities (AAA)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      103821782..103954056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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