Format

Send to:

Choose Destination
    • Showing Current items.

    Nsf N-ethylmaleimide sensitive fusion protein [ Mus musculus (house mouse) ]

    Gene ID: 18195, updated on 22-Aug-2021

    Summary

    Official Symbol
    Nsfprovided by MGI
    Official Full Name
    N-ethylmaleimide sensitive fusion proteinprovided by MGI
    Primary source
    MGI:MGI:104560
    See related
    Ensembl:ENSMUSG00000034187
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SKD; SKD2; AI316878; AU020090; AU067812
    Expression
    Broad expression in cerebellum adult (RPKM 105.1), frontal lobe adult (RPKM 99.1) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nsf in Genome Data Viewer
    Location:
    11 E1; 11 67.54 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103712608..103844882, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103821782..103954056, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (103683096..103815370, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C130046K22 gene Neighboring gene golgi SNAP receptor complex member 2 Neighboring gene wingless-type MMTV integration site family, member 9B Neighboring gene wingless-type MMTV integration site family, member 3 Neighboring gene VISTA enhancer mm1102 Neighboring gene predicted gene, 35365 Neighboring gene CDGSH iron-sulfur domain-containing protein 1 pseudogene Neighboring gene ADP-ribosylation factor 2 Neighboring gene predicted gene, 35420

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP hydrolysis activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables D1 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables syntaxin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables syntaxin-1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Golgi vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in SNARE complex disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Golgi stack IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    vesicle-fusing ATPase
    Names
    N-ethylmaleimide sensitive factor
    NEM-sensitive fusion protein
    suppressor of K(+) transport growth defect 2
    vesicular-fusion protein NSF
    NP_032766.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008740.4NP_032766.2  vesicle-fusing ATPase

      See identical proteins and their annotated locations for NP_032766.2

      Status: VALIDATED

      Source sequence(s)
      AL596108, AL603829
      Consensus CDS
      CCDS25524.1
      UniProtKB/Swiss-Prot
      P46460
      Related
      ENSMUSP00000099364.5, ENSMUST00000103075.11
      Conserved Domains (4) summary
      smart00382
      Location:254399
      AAA; ATPases associated with a variety of cellular activities
      smart01072
      Location:111183
      CDC48_2; Cell division protein 48 (CDC48) domain 2
      smart01073
      Location:683
      CDC48_N; Cell division protein 48 (CDC48) N-terminal domain
      pfam00004
      Location:256397
      AAA; ATPase family associated with various cellular activities (AAA)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      103712608..103844882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center