Format

Send to:

Choose Destination
    • Showing Current items.

    Nrf1 nuclear respiratory factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 18181, updated on 24-Feb-2019

    Summary

    Official Symbol
    Nrf1provided by MGI
    Official Full Name
    nuclear respiratory factor 1provided by MGI
    Primary source
    MGI:MGI:1332235
    See related
    Ensembl:ENSMUSG00000058440
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C87038; D6Ertd415e
    Expression
    Ubiquitous expression in thymus adult (RPKM 7.3), CNS E11.5 (RPKM 6.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nrf1 in Genome Data Viewer
    Location:
    6 A3.3; 6 12.47 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (30047988..30153458)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (29997988..30103458)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31103 Neighboring gene smal lysine rich protein 1, pseudogene Neighboring gene RIKEN cDNA 1700080G18 gene Neighboring gene microRNA cluster 35, host gene Neighboring gene microRNA 182 Neighboring gene microRNA 96

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    core promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to electrical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear respiratory factor 1
    Names
    NRF-1
    alpha palindromic-binding protein
    alpha-pal

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164226.1NP_001157698.1  nuclear respiratory factor 1 isoform a

      See identical proteins and their annotated locations for NP_001157698.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 6 encode the same protein (isoform a).
      Source sequence(s)
      AK029034, AK082580
      Consensus CDS
      CCDS19968.1
      UniProtKB/Swiss-Prot
      Q9WU00
      UniProtKB/TrEMBL
      Q8C4C0
      Related
      ENSMUSP00000110866.1, ENSMUST00000115211.7
      Conserved Domains (2) summary
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerisation domains of Nrf1
      pfam10492
      Location:450493
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    2. NM_001164227.1NP_001157699.1  nuclear respiratory factor 1 isoform b

      See identical proteins and their annotated locations for NP_001157699.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region which results in a frameshift and early stop codon, compared to variant 1. This results in a distinct and longer C-terminus in isoform b, compared to isoform a.
      Source sequence(s)
      AK037697, AK050861, AK082580
      Consensus CDS
      CCDS51741.1
      UniProtKB/TrEMBL
      Q8C4C0, Q8CAV3, Q99K73
      Related
      ENSMUSP00000110860.1, ENSMUST00000115206.7
      Conserved Domains (2) summary
      pfam06071
      Location:450526
      YchF-GTPase_C; Protein of unknown function (DUF933)
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerisation domains of Nrf1
    3. NM_001164228.1NP_001157700.1  nuclear respiratory factor 1 isoform c

      See identical proteins and their annotated locations for NP_001157700.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, lacks a 3' coding exon, and contains an alternate exon in the 3' coding region which results in a frameshift and early stop codon, compared to variant 1. This results in a distinct and shorter C-terminus in isoform c, compared to isoform a.
      Source sequence(s)
      AK050861, AK082580
      Consensus CDS
      CCDS51742.1
      UniProtKB/TrEMBL
      G3XA39, Q8C4C0
      Related
      ENSMUSP00000110858.1, ENSMUST00000115204.7
      Conserved Domains (1) summary
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerisation domains of Nrf1
    4. NM_001164229.1NP_001157701.1  nuclear respiratory factor 1 isoform d

      See identical proteins and their annotated locations for NP_001157701.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR, contains an alternate 5' coding exon, and contains an alternate exon in the 3' coding region which results in a frameshift and early stop codon, compared to variant 1. This results in a distinct and longer C-terminus in isoform d, compared to isoform a.
      Source sequence(s)
      AC153632, AK134483, AK135673
      Consensus CDS
      CCDS51739.1
      UniProtKB/TrEMBL
      Q3UXF4, Q3UYQ3
      Related
      ENSMUSP00000110853.1, ENSMUST00000115199.7
      Conserved Domains (1) summary
      pfam10491
      Location:87295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    5. NM_001164230.1NP_001157702.1  nuclear respiratory factor 1 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR and contains an alternate exon in the 3' coding region which results in a frameshift and early stop codon, compared to variant 1. This results in a distinct and shorter C-terminus in isoform e, compared to isoform a.
      Source sequence(s)
      AC153632, AK082580, AK134483
      Consensus CDS
      CCDS51740.1
      UniProtKB/TrEMBL
      E9Q7X0, Q3UYQ3, Q8C4C0
      Related
      ENSMUSP00000110854.1, ENSMUST00000115200.7
      Conserved Domains (1) summary
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    6. NM_001361692.1NP_001348621.1  nuclear respiratory factor 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC153632, AK029034, AK050861
      Conserved Domains (2) summary
      pfam06071
      Location:450526
      YchF-GTPase_C; Protein of unknown function (DUF933)
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerisation domains of Nrf1
    7. NM_001361693.1NP_001348622.1  nuclear respiratory factor 1 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC153632, AK029034, AK082580, AK135673
      Conserved Domains (2) summary
      pfam10491
      Location:87295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerisation domains of Nrf1
      pfam10492
      Location:462505
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    8. NM_001361694.1NP_001348623.1  nuclear respiratory factor 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC153632, AK029034, AK082580, BU707634
      Conserved Domains (2) summary
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerisation domains of Nrf1
      pfam10492
      Location:450493
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    9. NM_001361695.1NP_001348624.1  nuclear respiratory factor 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC153632, AK029034, AK050861, AK082580
      Conserved Domains (2) summary
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerisation domains of Nrf1
      pfam10492
      Location:450493
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    10. NM_010938.4NP_035068.3  nuclear respiratory factor 1 isoform a

      See identical proteins and their annotated locations for NP_035068.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 6 encode the same protein (isoform a).
      Source sequence(s)
      AK014494, AK082580
      Consensus CDS
      CCDS19968.1
      UniProtKB/Swiss-Prot
      Q9WU00
      UniProtKB/TrEMBL
      Q8C4C0
      Related
      ENSMUSP00000110867.1, ENSMUST00000115212.7
      Conserved Domains (2) summary
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerisation domains of Nrf1
      pfam10492
      Location:450493
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      30047988..30153458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505006.3XP_006505069.1  nuclear respiratory factor 1 isoform X2

      See identical proteins and their annotated locations for XP_006505069.1

      UniProtKB/TrEMBL
      Q99K73
      Related
      ENSMUSP00000065568.6, ENSMUST00000069808.12
      Conserved Domains (2) summary
      pfam06071
      Location:450526
      YchF-GTPase_C; Protein of unknown function (DUF933)
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerisation domains of Nrf1
    2. XM_011241048.1XP_011239350.1  nuclear respiratory factor 1 isoform X3

      See identical proteins and their annotated locations for XP_011239350.1

      Conserved Domains (2) summary
      pfam10491
      Location:87295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerisation domains of Nrf1
      pfam10492
      Location:462505
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    3. XM_011241044.1XP_011239346.1  nuclear respiratory factor 1 isoform X1

      See identical proteins and their annotated locations for XP_011239346.1

      Conserved Domains (2) summary
      pfam06071
      Location:462538
      YchF-GTPase_C; Protein of unknown function (DUF933)
      pfam10491
      Location:87295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    4. XM_006505005.3XP_006505068.1  nuclear respiratory factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006505068.1

      Conserved Domains (2) summary
      pfam06071
      Location:462538
      YchF-GTPase_C; Protein of unknown function (DUF933)
      pfam10491
      Location:87295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    5. XM_006505008.2XP_006505071.1  nuclear respiratory factor 1 isoform X5

      Conserved Domains (1) summary
      pfam10491
      Location:87295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    6. XM_017321441.1XP_017176930.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      Q99K73
      Conserved Domains (2) summary
      pfam06071
      Location:450526
      YchF-GTPase_C; Protein of unknown function (DUF933)
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerisation domains of Nrf1
    7. XM_017321443.1XP_017176932.1  nuclear respiratory factor 1 isoform X3

      Conserved Domains (2) summary
      pfam10491
      Location:87295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerisation domains of Nrf1
      pfam10492
      Location:462505
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    8. XM_017321445.1XP_017176934.1  nuclear respiratory factor 1 isoform X4

      UniProtKB/Swiss-Prot
      Q9WU00
      Conserved Domains (2) summary
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerisation domains of Nrf1
      pfam10492
      Location:450493
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    9. XM_017321440.1XP_017176929.1  nuclear respiratory factor 1 isoform X1

      Conserved Domains (2) summary
      pfam06071
      Location:462538
      YchF-GTPase_C; Protein of unknown function (DUF933)
      pfam10491
      Location:87295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    10. XM_017321442.1XP_017176931.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      Q99K73
      Conserved Domains (2) summary
      pfam06071
      Location:450526
      YchF-GTPase_C; Protein of unknown function (DUF933)
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerisation domains of Nrf1
    11. XM_017321444.1XP_017176933.1  nuclear respiratory factor 1 isoform X4

      UniProtKB/Swiss-Prot
      Q9WU00
      Conserved Domains (2) summary
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerisation domains of Nrf1
      pfam10492
      Location:450493
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    12. XM_011241046.2XP_011239348.1  nuclear respiratory factor 1 isoform X1

      See identical proteins and their annotated locations for XP_011239348.1

      Conserved Domains (2) summary
      pfam06071
      Location:462538
      YchF-GTPase_C; Protein of unknown function (DUF933)
      pfam10491
      Location:87295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    Support Center