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    Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 18174, updated on 12-Sep-2021

    Summary

    Official Symbol
    Slc11a2provided by MGI
    Official Full Name
    solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2provided by MGI
    Primary source
    MGI:MGI:1345279
    See related
    Ensembl:ENSMUSG00000023030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nr; mk; van; DCT1; DMT1; Nramp2
    Expression
    Ubiquitous expression in duodenum adult (RPKM 20.4), kidney adult (RPKM 16.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc11a2 in Genome Data Viewer
    Location:
    15 F1; 15 56.29 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100285779..100322090, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100387898..100424209, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (100218329..100253486, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 7A2 Neighboring gene methyltransferase hypoxia inducible domain containing 1 Neighboring gene HIG1 domain family, member 1C Neighboring gene predicted gene, 53911 Neighboring gene predicted gene 5475 Neighboring gene RIKEN cDNA 5330439K02 gene Neighboring gene LETM1 domain containing 1 Neighboring gene cysteine-serine-rich nuclear protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cadmium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cadmium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cadmium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cadmium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cobalt ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cobalt ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cobalt ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cobalt ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables copper ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ferrous iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ferrous iron transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ferrous iron transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables inorganic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables iron ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables iron ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lead ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lead ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables manganese ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nickel cation binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nickel cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nickel cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables proton transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables retromer complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables solute:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transition metal ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables vanadium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cadmium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cobalt ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cobalt ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in copper ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in copper ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in iron import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within iron import into cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within iron import into cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in iron import into cell ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in iron ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within iron ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within iron ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in iron ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lead ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in manganese ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organismal iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organismal iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organismal iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nickel cation transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within porphyrin-containing compound biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within porphyrin-containing compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within proton transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to manganese ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transition metal ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vanadium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in apical part of cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of paraferritin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vacuole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    natural resistance-associated macrophage protein 2
    Names
    DMT-1
    NRAMP 2
    divalent cation transporter 1
    divalent metal transporter 1
    microcytic anemia, viable anaemia
    solute carrier family 11 member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146161.1NP_001139633.1  natural resistance-associated macrophage protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001139633.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. This variant has a stem-loop iron response element (IRE) in the 3' UTR.
      Source sequence(s)
      AK049856, CJ057283
      Consensus CDS
      CCDS49733.1
      UniProtKB/Swiss-Prot
      P49282
      Related
      ENSMUSP00000116463.2, ENSMUST00000138843.8
      Conserved Domains (2) summary
      TIGR01197
      Location:68467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
      pfam01566
      Location:90473
      Nramp; Natural resistance-associated macrophage protein
    2. NM_001356952.1NP_001343881.1  natural resistance-associated macrophage protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC139571
      Conserved Domains (1) summary
      cl00456
      Location:1203
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. NM_008732.2NP_032758.2  natural resistance-associated macrophage protein 2 isoform 2

      See identical proteins and their annotated locations for NP_032758.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. These differences result in a protein (isoform 2) with a longer and distinct C-terminus, compared to isoform 1. This variant does not have a stem-loop iron response element (IRE) in the 3' UTR.
      Source sequence(s)
      AK049856, CJ057283, L33415
      Consensus CDS
      CCDS37211.1
      UniProtKB/Swiss-Prot
      P49282
      Related
      ENSMUSP00000023774.6, ENSMUST00000023774.12
      Conserved Domains (1) summary
      TIGR01197
      Location:68467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      100285779..100322090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245487.3XP_011243789.1  natural resistance-associated macrophage protein 2 isoform X1

      UniProtKB/Swiss-Prot
      P49282
      Conserved Domains (1) summary
      TIGR01197
      Location:98497
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    2. XM_006520580.4XP_006520643.1  natural resistance-associated macrophage protein 2 isoform X5

      Conserved Domains (1) summary
      cl00456
      Location:1203
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. XM_006520579.5XP_006520642.1  natural resistance-associated macrophage protein 2 isoform X3

      Conserved Domains (1) summary
      TIGR01197
      Location:1388
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    4. XM_030248382.2XP_030104242.1  natural resistance-associated macrophage protein 2 isoform X5

      Conserved Domains (1) summary
      cl00456
      Location:1203
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    5. XM_006520578.4XP_006520641.1  natural resistance-associated macrophage protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006520641.1

      UniProtKB/Swiss-Prot
      P49282
      Conserved Domains (1) summary
      TIGR01197
      Location:68467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    6. XM_006520577.5XP_006520640.1  natural resistance-associated macrophage protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006520640.1

      UniProtKB/Swiss-Prot
      P49282
      Conserved Domains (1) summary
      TIGR01197
      Location:68467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    7. XM_030248381.2XP_030104241.1  natural resistance-associated macrophage protein 2 isoform X4

      Conserved Domains (1) summary
      TIGR01197
      Location:1388
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    8. XM_030248383.2XP_030104243.1  natural resistance-associated macrophage protein 2 isoform X6

      Conserved Domains (1) summary
      cl00456
      Location:1203
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
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