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    Nos1 nitric oxide synthase 1, neuronal [ Mus musculus (house mouse) ]

    Gene ID: 18125, updated on 5-Sep-2021

    Summary

    Official Symbol
    Nos1provided by MGI
    Official Full Name
    nitric oxide synthase 1, neuronalprovided by MGI
    Primary source
    MGI:MGI:97360
    See related
    Ensembl:ENSMUSG00000029361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    b; NO; NOS; bNOS; nNOS; N-NOS; NOS-I; Nos-1; NC-NOS; 2310005C01Rik
    Expression
    Biased expression in cerebellum adult (RPKM 7.6), frontal lobe adult (RPKM 4.0) and 12 other tissues See more
    Orthologs
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    Genomic context

    See Nos1 in Genome Data Viewer
    Location:
    5 F; 5 57.29 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (118004904..118096905)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117866839..117958840)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (118317128..118403822)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52829 Neighboring gene kinase suppressor of ras 2 Neighboring gene predicted gene, 42013 Neighboring gene Nos1 exon 2 regulatory region Neighboring gene predicted gene, 30360 Neighboring gene predicted gene, 26995 Neighboring gene F-box protein 21 Neighboring gene tescalcin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables FMN binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cadmium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nitric-oxide synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nitric-oxide synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in arginine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in arginine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in behavioral response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to epinephrine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in multicellular organismal response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hepatic stellate cell contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of iron ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of serotonin uptake IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nitric oxide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nitric oxide mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nitric oxide mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptidyl-cysteine S-nitrosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-cysteine S-nitrosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of histone acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of the force of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neurogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde trans-synaptic signaling by nitric oxide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in retrograde trans-synaptic signaling by nitric oxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within striated muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic signaling by nitric oxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic signaling by nitric oxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within xenobiotic catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in azurophil granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in calyx of Held IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in calyx of Held IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    colocalizes_with caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nitric oxide synthase, brain
    Names
    NOS type I
    constitutive NOS
    neuronal NOS
    neuronal nitric oxide synthase
    peptidyl-cysteine S-nitrosylase NOS1
    NP_032738.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008712.3NP_032738.1  nitric oxide synthase, brain

      See identical proteins and their annotated locations for NP_032738.1

      Status: VALIDATED

      Source sequence(s)
      AC114617, AC114993
      Consensus CDS
      CCDS19606.1
      UniProtKB/Swiss-Prot
      Q9Z0J4
      Related
      ENSMUSP00000127432.2, ENSMUST00000171055.2
      Conserved Domains (5) summary
      cd06202
      Location:9961399
      Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
      COG0369
      Location:7541394
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      cd00795
      Location:300711
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      cd00992
      Location:1598
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00258
      Location:757930
      Flavodoxin_1; Flavodoxin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      118004904..118096905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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