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    DRD1 dopamine receptor D1 [ Homo sapiens (human) ]

    Gene ID: 1812, updated on 18-Sep-2024

    Summary

    Official Symbol
    DRD1provided by HGNC
    Official Full Name
    dopamine receptor D1provided by HGNC
    Primary source
    HGNC:HGNC:3020
    See related
    Ensembl:ENSG00000184845 MIM:126449; AllianceGenome:HGNC:3020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    D1R; DADR; DRD1A
    Summary
    This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 3.4), placenta (RPKM 0.8) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DRD1 in Genome Data Viewer
    Location:
    5q35.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (175440036..175444182, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (175983814..175987960, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (174867039..174871185, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986484 Neighboring gene Sharpr-MPRA regulatory region 3886 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:174550039-174551238 Neighboring gene Sharpr-MPRA regulatory region 8865 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:174697681-174698880 Neighboring gene ARF like GTPase 2 binding protein pseudogene 6 Neighboring gene MPRA-validated peak5585 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr5:174756399-174756570 Neighboring gene NANOG hESC enhancer GRCh37_chr5:174789537-174790038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:174824457-174825029 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:174861879-174862482 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:174863593-174864097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16643 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16644 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr5:174905945-174906540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:174911541-174912114 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:174943953-174945152 Neighboring gene sideroflexin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat and methamphetamine inhibit the normal conjunction of signaling between D1 and NMDA receptors, resulting in neural dysfunction and death PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in D-glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled dopamine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating dopamine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adult walking behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in astrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in behavioral response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to catecholamine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cerebral cortex GABAergic interneuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in conditioned taste aversion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dentate gyrus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dopamine metabolic process IC
    Inferred by Curator
    more info
    PubMed 
    involved_in dopamine transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in grooming behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in habituation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term synaptic depression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maternal behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mating behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modification of postsynaptic structure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuronal action potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in operant conditioning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peristalsis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating dopamine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of release of sequestered calcium ion into cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in prepulse inhibition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of dopamine uptake involved in synaptic transmission IC
    Inferred by Curator
    more info
    PubMed 
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sensitization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in striatum development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synaptic transmission, dopaminergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in temperature homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmission of nerve impulse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vasodilation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in visual learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of G protein-coupled receptor complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    D(1A) dopamine receptor
    Names
    dopamine D1 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011802.1 RefSeqGene

      Range
      4979..9125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000794.5NP_000785.1  D(1A) dopamine receptor

      See identical proteins and their annotated locations for NP_000785.1

      Status: REVIEWED

      Source sequence(s)
      AC091393
      Consensus CDS
      CCDS4393.1
      UniProtKB/Swiss-Prot
      B2RA44, P21728, Q4QRJ0
      UniProtKB/TrEMBL
      Q6FH34
      Related
      ENSP00000377353.1, ENST00000393752.3
      Conserved Domains (1) summary
      cd15320
      Location:23341
      7tmA_D1A_dopamine_R; D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      175440036..175444182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      175983814..175987960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)