U.S. flag

An official website of the United States government


Send to:

Choose Destination
    • Showing Current items.

    Emc8 ER membrane protein complex subunit 8 [ Mus musculus (house mouse) ]

    Gene ID: 18117, updated on 5-Mar-2024


    Official Symbol
    Emc8provided by MGI
    Official Full Name
    ER membrane protein complex subunit 8provided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000031819 AllianceGenome:MGI:1343095
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Noc4; Cox4nb; Fam158b
    Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human EMC8 (ER membrane protein complex subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
    Ubiquitous expression in ovary adult (RPKM 15.9), adrenal adult (RPKM 11.0) and 28 other tissues See more
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Emc8 in Genome Data Viewer
    8 E1; 8 69.98 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (121380653..121394826, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (120653914..120668087, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10614 Neighboring gene RIKEN cDNA 1190005I06 gene Neighboring gene predicted gene, 27021 Neighboring gene STARR-seq mESC enhancer starr_22909 Neighboring gene predicted gene, 33075 Neighboring gene cytochrome c oxidase subunit 4I1 Neighboring gene predicted gene, 39265

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Readthrough Gm27021

    Readthrough gene: Gm27021, Included gene: 1190005I06Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    part_of EMC complex ISO
    Inferred from Sequence Orthology
    more info
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    ER membrane protein complex subunit 8
    COX4 neighbor
    neighbor of Cox4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010926.6NP_035056.1  ER membrane protein complex subunit 8

      See identical proteins and their annotated locations for NP_035056.1

      Status: VALIDATED

      Source sequence(s)
      Consensus CDS
      Q3TPU5, Q3TTC9, Q8C988
      ENSMUSP00000034277.7, ENSMUST00000034277.14
      Conserved Domains (1) summary
      MPN_UPF0172; Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000074.7 Reference GRCm39 C57BL/6J

      121380653..121394826 complement
      GenBank, FASTA, Sequence Viewer (Graphics)