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    Nmt2 N-myristoyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 18108, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nmt2provided by MGI
    Official Full Name
    N-myristoyltransferase 2provided by MGI
    Primary source
    MGI:MGI:1202298
    See related
    Ensembl:ENSMUSG00000026643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hNMT-; hNMT-2; AI605445; AU044698; A930001K02Rik
    Expression
    Broad expression in frontal lobe adult (RPKM 16.8), CNS E18 (RPKM 14.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Nmt2 in Genome Data Viewer
    Location:
    2; 2 A1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (3285249..3329914)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (3284212..3328877)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (3201560..3243641)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 171, member A1 Neighboring gene predicted gene, 54098 Neighboring gene predicted gene, 22005 Neighboring gene ribonuclease P/MRP 38 subunit Neighboring gene acyl-Coenzyme A binding domain containing 7 Neighboring gene oleoyl-ACP hydrolase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glycylpeptide N-tetradecanoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glycylpeptide N-tetradecanoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables glycylpeptide N-tetradecanoyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glycylpeptide N-tetradecanoyltransferase 2
    Names
    myristoyl-CoA:protein N-myristoyltransferase 2
    peptide N-myristoyltransferase 2
    type II N-myristoyltransferase
    NP_001277297.1
    NP_001277298.1
    NP_001277299.1
    NP_032734.1
    XP_036015249.1
    XP_036015250.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290368.1NP_001277297.1  glycylpeptide N-tetradecanoyltransferase 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site that results in translation initiation at an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK161490, AL732620, AL928883
      Conserved Domains (2) summary
      pfam01233
      Location:133287
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:303478
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
    2. NM_001290369.1NP_001277298.1  glycylpeptide N-tetradecanoyltransferase 2 isoform c

      See identical proteins and their annotated locations for NP_001277298.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon that results in translation initiation at an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK134521, AL732620, AL928883
      Consensus CDS
      CCDS70972.1
      UniProtKB/TrEMBL
      F7APP3, Q3THR4
      Related
      ENSMUSP00000089085.5, ENSMUST00000091504.5
      Conserved Domains (2) summary
      pfam01233
      Location:127281
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:297472
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
    3. NM_001290370.1NP_001277299.1  glycylpeptide N-tetradecanoyltransferase 2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AK134521, AL732620, AL928883
      Consensus CDS
      CCDS70971.1
      UniProtKB/TrEMBL
      A2AJH3, Q3THR4
      Related
      ENSMUSP00000100054.4, ENSMUST00000102989.10
      Conserved Domains (2) summary
      pfam01233
      Location:140294
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:310485
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
    4. NM_008708.2NP_032734.1  glycylpeptide N-tetradecanoyltransferase 2 isoform a

      See identical proteins and their annotated locations for NP_032734.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK134521, AL732620, AL928883
      Consensus CDS
      CCDS15644.1
      UniProtKB/Swiss-Prot
      O70311
      UniProtKB/TrEMBL
      Q3THR4
      Related
      ENSMUSP00000080600.7, ENSMUST00000081932.13
      Conserved Domains (2) summary
      pfam01233
      Location:171325
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:341516
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      3285249..3329914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159357.1XP_036015250.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X2

      Conserved Domains (1) summary
      COG5092
      Location:22389
      NMT1; N-myristoyl transferase [Lipid metabolism]
    2. XM_036159356.1XP_036015249.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X1

      Conserved Domains (1) summary
      COG5092
      Location:55422
      NMT1; N-myristoyl transferase [Lipid metabolism]
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