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    Nmt2 N-myristoyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 18108, updated on 23-May-2018

    Summary

    Official Symbol
    Nmt2provided by MGI
    Official Full Name
    N-myristoyltransferase 2provided by MGI
    Primary source
    MGI:MGI:1202298
    See related
    Ensembl:ENSMUSG00000026643 Vega:OTTMUSG00000010789
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hNMT-2; AI605445; AU044698; A930001K02Rik
    Expression
    Broad expression in frontal lobe adult (RPKM 16.8), CNS E18 (RPKM 14.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See Nmt2 in Genome Data Viewer
    Location:
    2; 2 A1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (3284212..3328877)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (3201560..3243641)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 171, member A1 Neighboring gene ribonuclease P/MRP 38 subunit Neighboring gene acyl-Coenzyme A binding domain containing 7 Neighboring gene oleoyl-ACP hydrolase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    glycylpeptide N-tetradecanoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glycylpeptide N-tetradecanoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glycylpeptide N-tetradecanoyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    N-terminal peptidyl-glycine N-myristoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    N-terminal peptidyl-glycine N-myristoylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    N-terminal protein myristoylation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glycylpeptide N-tetradecanoyltransferase 2
    Names
    myristoyl-CoA:protein N-myristoyltransferase 2
    peptide N-myristoyltransferase 2
    type II N-myristoyltransferase
    NP_001277297.1
    NP_001277298.1
    NP_001277299.1
    NP_032734.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290368.1NP_001277297.1  glycylpeptide N-tetradecanoyltransferase 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site that results in translation initiation at an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK161490, AL732620, AL928883
      Conserved Domains (2) summary
      pfam01233
      Location:133287
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:303478
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
    2. NM_001290369.1NP_001277298.1  glycylpeptide N-tetradecanoyltransferase 2 isoform c

      See identical proteins and their annotated locations for NP_001277298.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon that results in translation initiation at an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK134521, AL732620, AL928883
      Consensus CDS
      CCDS70972.1
      UniProtKB/TrEMBL
      F7APP3, Q3THR4
      Related
      ENSMUSP00000089085.4, OTTMUSP00000011578, ENSMUST00000091504.4, OTTMUST00000025233
      Conserved Domains (2) summary
      pfam01233
      Location:127281
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:297472
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
    3. NM_001290370.1NP_001277299.1  glycylpeptide N-tetradecanoyltransferase 2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AK134521, AL732620, AL928883
      Consensus CDS
      CCDS70971.1
      UniProtKB/TrEMBL
      A2AJH3, Q3THR4
      Related
      ENSMUSP00000100054.3, OTTMUSP00000011579, ENSMUST00000102989.9, OTTMUST00000025234
      Conserved Domains (2) summary
      pfam01233
      Location:140294
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:310485
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
    4. NM_008708.2NP_032734.1  glycylpeptide N-tetradecanoyltransferase 2 isoform a

      See identical proteins and their annotated locations for NP_032734.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK134521, AL732620, AL928883
      Consensus CDS
      CCDS15644.1
      UniProtKB/Swiss-Prot
      O70311
      UniProtKB/TrEMBL
      Q3THR4
      Related
      ENSMUSP00000080600.6, OTTMUSP00000011577, ENSMUST00000081932.12, OTTMUST00000025232
      Conserved Domains (2) summary
      pfam01233
      Location:171325
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:341516
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      3284212..3328877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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