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    DR1 down-regulator of transcription 1 [ Homo sapiens (human) ]

    Gene ID: 1810, updated on 5-May-2024

    Summary

    Official Symbol
    DR1provided by HGNC
    Official Full Name
    down-regulator of transcription 1provided by HGNC
    Primary source
    HGNC:HGNC:3017
    See related
    Ensembl:ENSG00000117505 MIM:601482; AllianceGenome:HGNC:3017
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NC2; NC2B; NCB2; NC2-BETA
    Summary
    This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 31.0), lymph node (RPKM 21.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DR1 in Genome Data Viewer
    Location:
    1p22.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (93345907..93369493)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (93191628..93215212)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (93811464..93835050)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 pseudogene Neighboring gene CCDC18 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1329 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:93811059-93811594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1331 Neighboring gene F-box and WD repeat domain containing 11 pseudogene Neighboring gene Sharpr-MPRA regulatory region 11866 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:93913324-93914302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:93920247-93920766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:93920767-93921285 Neighboring gene formin binding protein 1 like Neighboring gene MPRA-validated peak323 silencer Neighboring gene RNA, 5S ribosomal pseudogene 53

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Interaction of HIV-1 Tat with TBP/TFIID competes with negative cofactor Dr1 interaction with TBP, thereby inhibiting Dr1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II general transcription initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables TBP-class protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables TBP-class protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables TBP-class protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of tubulin deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of tubulin deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of negative cofactor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    protein Dr1
    Names
    TATA-binding protein-associated phosphoprotein
    negative cofactor 2
    negative cofactor 2-beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001938.3NP_001929.1  protein Dr1

      See identical proteins and their annotated locations for NP_001929.1

      Status: REVIEWED

      Source sequence(s)
      AL137159, AL833729, BC035507
      Consensus CDS
      CCDS744.1
      UniProtKB/Swiss-Prot
      Q01658
      UniProtKB/TrEMBL
      D3DT41, Q658N3
      Related
      ENSP00000359295.3, ENST00000370272.9
      Conserved Domains (1) summary
      cl23735
      Location:7130
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      93345907..93369493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      93191628..93215212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)