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    Nlk nemo like kinase [ Mus musculus (house mouse) ]

    Gene ID: 18099, updated on 7-Aug-2021

    Summary

    Official Symbol
    Nlkprovided by MGI
    Official Full Name
    nemo like kinaseprovided by MGI
    Primary source
    MGI:MGI:1201387
    See related
    Ensembl:ENSMUSG00000017376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI194375
    Expression
    Ubiquitous expression in cortex adult (RPKM 16.4), frontal lobe adult (RPKM 14.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nlk in Genome Data Viewer
    Location:
    11; 11 B5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78457994..78588848, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78567168..78697595, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (78380670..78510927, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L10 pseudogene Neighboring gene predicted gene, 22947 Neighboring gene annexin A2 pseudogene Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene 40S ribosomal protein SA-like Neighboring gene cyclin Q

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase NLK
    NP_032728.3
    XP_036012300.1
    XP_036012301.1
    XP_036012302.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008702.3NP_032728.3  serine/threonine-protein kinase NLK

      See identical proteins and their annotated locations for NP_032728.3

      Status: VALIDATED

      Source sequence(s)
      AK078118, AK160340, BU923375, BY137033, BY237029, CB234984, CO042120
      Consensus CDS
      CCDS25113.2
      UniProtKB/Swiss-Prot
      O54949
      UniProtKB/TrEMBL
      Q3TV73
      Related
      ENSMUSP00000119345.2, ENSMUST00000142739.8
      Conserved Domains (1) summary
      cd07853
      Location:137508
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78457994..78588848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156409.1XP_036012302.1  serine/threonine-protein kinase NLK isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1287
      PKc_like; Protein Kinases, catalytic domain
    2. XM_036156408.1XP_036012301.1  serine/threonine-protein kinase NLK isoform X2

      Conserved Domains (1) summary
      cd07853
      Location:2356
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
    3. XM_036156407.1XP_036012300.1  serine/threonine-protein kinase NLK isoform X1

      Conserved Domains (1) summary
      cd07853
      Location:22376
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

    RNA

    1. XR_001779914.2 RNA Sequence

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