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    DPYSL3 dihydropyrimidinase like 3 [ Homo sapiens (human) ]

    Gene ID: 1809, updated on 5-May-2024

    Summary

    Official Symbol
    DPYSL3provided by HGNC
    Official Full Name
    dihydropyrimidinase like 3provided by HGNC
    Primary source
    HGNC:HGNC:3015
    See related
    Ensembl:ENSG00000113657 MIM:601168; AllianceGenome:HGNC:3015
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRP3; ULIP; CRMP4; DRP-3; LCRMP; CRMP-4; ULIP-1
    Summary
    Enables filamin binding activity. Predicted to be involved in several processes, including actin filament organization; regulation of plasma membrane bounded cell projection organization; and response to axon injury. Predicted to act upstream of or within nervous system development. Predicted to be located in several cellular components, including cell body; growth cone; and lamellipodium. Predicted to be part of filamentous actin. Predicted to be active in synapse. Predicted to colocalize with exocytic vesicle. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 51.8), prostate (RPKM 49.3) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DPYSL3 in Genome Data Viewer
    Location:
    5q32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (147390808..147510068, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (147926586..148045847, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (146770371..146889631, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 regulatory subunit Bbeta Neighboring gene uncharacterized LOC105378214 Neighboring gene PPP2R2B intronic transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23362 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:146473503-146474702 Neighboring gene STK32A antisense RNA 1 Neighboring gene serine/threonine kinase 32A Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81891 Neighboring gene NANOG hESC enhancer GRCh37_chr5:146835510-146836011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16489 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:146935385-146935884 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:146940356-146941285 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:146946379-146947278 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:146947279-146948178 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:146948179-146949078 Neighboring gene JAKMIP2 antisense RNA 1 Neighboring gene janus kinase and microtubule interacting protein 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:147051411-147052610 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:147101014-147101804 Neighboring gene uncharacterized LOC105378218

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH3 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chondroitin sulfate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT enables dihydropyrimidinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables filamin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin crosslink formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in actin filament bundle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to cytokine stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in pyrimidine nucleobase catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to axon injury ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    colocalizes_with exocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of filamentous actin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dihydropyrimidinase-related protein 3
    Names
    collapsin response mediator protein 4 long
    testicular secretory protein Li 7
    unc-33-like phosphoprotein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197294.2NP_001184223.1  dihydropyrimidinase-related protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001184223.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC011373, BC077077, CA424493, D78014
      Consensus CDS
      CCDS56387.1
      UniProtKB/TrEMBL
      A0A140VK07, Q6DEN2
      Related
      ENSP00000343690.5, ENST00000343218.10
      Conserved Domains (2) summary
      TIGR02033
      Location:131585
      D-hydantoinase
      cl14632
      Location:574679
      VOC; vicinal oxygen chelate (VOC) family
    2. NM_001387.3NP_001378.1  dihydropyrimidinase-related protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001378.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform (1).
      Source sequence(s)
      AI570709, BC039006, CA424493, D78014
      Consensus CDS
      CCDS43381.1
      UniProtKB/Swiss-Prot
      B3SXQ8, Q14195, Q93012
      UniProtKB/TrEMBL
      Q8IXW6
      Related
      ENSP00000381526.3, ENST00000398514.7
      Conserved Domains (1) summary
      TIGR02033
      Location:17471
      D-hydantoinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      147390808..147510068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537574.3XP_011535876.1  dihydropyrimidinase-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011535876.1

      UniProtKB/TrEMBL
      Q8IXW6
      Conserved Domains (2) summary
      TIGR02033
      Location:13467
      D-hydantoinase
      cl14632
      Location:456561
      VOC; vicinal oxygen chelate (VOC) family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      147926586..148045847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351956.1XP_054207931.1  dihydropyrimidinase-related protein 3 isoform X1