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    DPYSL2 dihydropyrimidinase like 2 [ Homo sapiens (human) ]

    Gene ID: 1808, updated on 5-May-2024

    Summary

    Official Symbol
    DPYSL2provided by HGNC
    Official Full Name
    dihydropyrimidinase like 2provided by HGNC
    Primary source
    HGNC:HGNC:3014
    See related
    Ensembl:ENSG00000092964 MIM:602463; AllianceGenome:HGNC:3014
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2
    Summary
    This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
    Annotation information
    Note: DRP2 (Gene ID: 1821) and DPYSL2 (Gene ID: 1808) share the DRP2 symbol/alias in common. DRP2 is a widely used alternative name for dihydropyrimidinase like 2 (DPYSL2), which can be confused with the official symbol for dystrophin related protein 2 (DRP2). [06 Jul 2018]
    Expression
    Broad expression in brain (RPKM 146.0), lung (RPKM 48.2) and 15 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DPYSL2 in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (26514031..26658175)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (26790610..26934895)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (26371547..26515691)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene vegetative cell wall protein gp1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:26346103-26346626 Neighboring gene Sharpr-MPRA regulatory region 13991 Neighboring gene PNMA family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:26433901-26434598 Neighboring gene proteasome activator subunit 2 pseudogene 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:26434599-26435296 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:26435598-26436492 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:26436493-26437387 Neighboring gene uncharacterized LOC124901916 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:26448723-26449328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27130 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:26485007-26485506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27131 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:26494036-26495000 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:26495001-26495965 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:26500941-26501851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:26518635-26519136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:26519137-26519636 Neighboring gene adrenoceptor alpha 1A Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 9 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat induces hyperphosphorylation of CRMP2 in neuronal cells PubMed
    tat Expression of HIV-1 Tat upregulates the abundance of dihydropyrimidinase-like 2 (DPYSL2, CRMP2) in the nucleoli of Jurkat T-cells PubMed
    tat A peptide of CRMP-2 fused to the HIV transactivator of transcription Tat protein decreases neuropeptide release from sensory neurons PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables dihydropyrimidinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleobase-containing compound metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    NOT involved_in pyrimidine nucleobase catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    colocalizes_with membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    dihydropyrimidinase-related protein 2
    Names
    collapsin response mediator protein hCRMP-2
    unc-33-like phosphoprotein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030020.1 RefSeqGene

      Range
      4839..148983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001197293.3NP_001184222.1  dihydropyrimidinase-related protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001184222.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB209195, AC015564, AC015743, BC056408, BX463316, DA649686
      Consensus CDS
      CCDS83268.1
      UniProtKB/TrEMBL
      A0A1C7CYX9, Q59GB4
      Related
      ENSP00000427985.2, ENST00000521913.7
      Conserved Domains (1) summary
      cd01314
      Location:122571
      D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
    2. NM_001244604.2NP_001231533.1  dihydropyrimidinase-related protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001231533.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC015564, AK299077, BC056408, BP222303, BX463316
      Consensus CDS
      CCDS59096.1
      UniProtKB/TrEMBL
      Q53ET2
      Related
      ENSP00000431117.1, ENST00000523027.1
      Conserved Domains (1) summary
      cd01314
      Location:1430
      D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
    3. NM_001386.6NP_001377.1  dihydropyrimidinase-related protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001377.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC015564, BC056408, BX461557, DC333865
      Consensus CDS
      CCDS6051.1
      UniProtKB/Swiss-Prot
      A8K5H2, B4DR31, D3DSS7, O00424, Q16555
      UniProtKB/TrEMBL
      Q53ET2
      Related
      ENSP00000309539.5, ENST00000311151.9
      Conserved Domains (1) summary
      cd01314
      Location:17466
      D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      26514031..26658175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      26790610..26934895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)