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    pdk-1 3-phosphoinositide-dependent protein kinase 1 [ Caenorhabditis elegans ]

    Gene ID: 180475, updated on 2-Nov-2024

    Summary

    Official Symbol
    pdk-1
    Official Full Name
    3-phosphoinositide-dependent protein kinase 1
    Primary source
    WormBase:WBGene00003965
    Locus tag
    CELE_H42K12.1
    See related
    AllianceGenome:WB:WBGene00003965
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein kinase activity. Involved in several processes, including cellular response to reactive oxygen species; dauer larval development; and regulation of synaptic assembly at neuromuscular junction. Located in axon; neuronal cell body; and nucleus. Is expressed in several structures, including gonad; intestine; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See pdk-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (1321344..1327986)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Apple domain-containing protein Neighboring gene CX domain-containing protein Neighboring gene Transthyretin-like family protein Neighboring gene INSulin related

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity, acting on a protein IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to metal ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    3-phosphoinositide-dependent protein kinase 1
    NP_001024742.1
    • Confirmed by transcript evidence
    NP_001024743.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      1321344..1327986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029572.4NP_001024743.1  3-phosphoinositide-dependent protein kinase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024743.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9UA36, Q9Y1J3
      Conserved Domains (3) summary
      smart00220
      Location:69364
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01262
      Location:464570
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:67364
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
    2. NM_001029571.4NP_001024742.1  3-phosphoinositide-dependent protein kinase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024742.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9Y1J3
      Conserved Domains (3) summary
      smart00220
      Location:69362
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01262
      Location:460566
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:67362
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1