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    Nfya nuclear transcription factor-Y alpha [ Mus musculus (house mouse) ]

    Gene ID: 18044, updated on 16-Aug-2021

    Summary

    Official Symbol
    Nfyaprovided by MGI
    Official Full Name
    nuclear transcription factor-Y alphaprovided by MGI
    Primary source
    MGI:MGI:97316
    See related
    Ensembl:ENSMUSG00000023994
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sez1; Cbf-b; SEZ10; SEZ-10; AA407810
    Expression
    Ubiquitous expression in thymus adult (RPKM 28.3), ovary adult (RPKM 24.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nfya in Genome Data Viewer
    Location:
    17 C; 17 23.99 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48693913..48716848, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48386885..48409820, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (48526210..48549145, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene triggering receptor expressed on myeloid cells 2 Neighboring gene triggering receptor expressed on myeloid cells-like 1 Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 Neighboring gene predicted gene, 30283

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    contributes_to transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of CCAAT-binding factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of CCAAT-binding factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear transcription factor Y subunit alpha
    Names
    CAAT box DNA-binding protein subunit A
    NF-YA
    nuclear transcription factor Y subunit A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110832.1NP_001104302.1  nuclear transcription factor Y subunit alpha isoform a

      See identical proteins and their annotated locations for NP_001104302.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BC057099, BY127163, CO044864
      Consensus CDS
      CCDS50142.1
      UniProtKB/TrEMBL
      Q9DBV7
      Related
      ENSMUSP00000043909.8, ENSMUST00000046719.14
      Conserved Domains (1) summary
      pfam02045
      Location:263318
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
    2. NM_001347401.1NP_001334330.1  nuclear transcription factor Y subunit alpha isoform c

      Status: VALIDATED

      Source sequence(s)
      AC166164, CO044864
      Consensus CDS
      CCDS84321.1
      UniProtKB/Swiss-Prot
      P23708
      Conserved Domains (1) summary
      pfam02045
      Location:262317
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
    3. NM_001347402.1NP_001334331.1  nuclear transcription factor Y subunit alpha isoform d

      Status: VALIDATED

      Source sequence(s)
      AC166164, CO044864
      Consensus CDS
      CCDS84320.1
      UniProtKB/Swiss-Prot
      P23708
      UniProtKB/TrEMBL
      A0A0R4J1Y8
      Related
      ENSMUSP00000124404.2, ENSMUST00000159063.8
      Conserved Domains (1) summary
      pfam02045
      Location:228283
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
    4. NM_001374803.1NP_001361732.1  nuclear transcription factor Y subunit alpha isoform e

      Status: VALIDATED

      Source sequence(s)
      AC166164
      Consensus CDS
      CCDS89116.1
      Related
      ENSMUSP00000124245.2, ENSMUST00000160319.8
      Conserved Domains (1) summary
      pfam02045
      Location:257312
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
    5. NM_010913.2NP_035043.1  nuclear transcription factor Y subunit alpha isoform b

      See identical proteins and their annotated locations for NP_035043.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in a longer protein (isoform b).
      Source sequence(s)
      BC057099, BY127163, CO044864, X55315
      Consensus CDS
      CCDS28867.1
      UniProtKB/Swiss-Prot
      P23708
      UniProtKB/TrEMBL
      Q3UP82, Q9DBV7
      Related
      ENSMUSP00000123785.2, ENSMUST00000162460.8
      Conserved Domains (1) summary
      pfam02045
      Location:234289
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48693913..48716848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317292.3XP_017172781.1  nuclear transcription factor Y subunit alpha isoform X2

      Conserved Domains (1) summary
      pfam02045
      Location:262317
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
    2. XM_030249554.2XP_030105414.1  nuclear transcription factor Y subunit alpha isoform X7

      Conserved Domains (1) summary
      pfam02045
      Location:228283
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
    3. XM_030249553.1XP_030105413.1  nuclear transcription factor Y subunit alpha isoform X5

      Conserved Domains (1) summary
      pfam02045
      Location:256311
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
    4. XM_030249551.2XP_030105411.1  nuclear transcription factor Y subunit alpha isoform X1

      Related
      ENSMUSP00000077853.7, ENSMUST00000078800.13
      Conserved Domains (1) summary
      pfam02045
      Location:262317
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
    5. XM_006523793.3XP_006523856.1  nuclear transcription factor Y subunit alpha isoform X3

      Conserved Domains (1) summary
      pfam02045
      Location:261316
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
    6. XM_006523795.3XP_006523858.1  nuclear transcription factor Y subunit alpha isoform X6

      See identical proteins and their annotated locations for XP_006523858.1

      Conserved Domains (1) summary
      pfam02045
      Location:255310
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
    7. XM_030249552.2XP_030105412.1  nuclear transcription factor Y subunit alpha isoform X4

      Conserved Domains (1) summary
      pfam02045
      Location:256311
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
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