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    Nfs1 nitrogen fixation gene 1 (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 18041, updated on 18-Sep-2024

    Summary

    Official Symbol
    Nfs1provided by MGI
    Official Full Name
    nitrogen fixation gene 1 (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1316706
    See related
    Ensembl:ENSMUSG00000027618 AllianceGenome:MGI:1316706
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    m-Nfs1; m-Nfsl
    Summary
    Predicted to enable cysteine desulfurase activity and protein homodimerization activity. Involved in iron incorporation into metallo-sulfur cluster. Located in mitochondrial matrix and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human NFS1 (NFS1 cysteine desulfurase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 43.8), adrenal adult (RPKM 39.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nfs1 in Genome Data Viewer
    Location:
    2 H1; 2 77.34 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155965569..155986106, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156123637..156144202, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 4 Neighboring gene copine I Neighboring gene STARR-seq mESC enhancer starr_06153 Neighboring gene STARR-positive B cell enhancer ABC_E3414 Neighboring gene RNA binding motif protein 12 Neighboring gene reactive oxygen species modulator 1 Neighboring gene RNA binding motif protein 39 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156005117-156005304 Neighboring gene STARR-positive B cell enhancer ABC_E817 Neighboring gene STARR-seq mESC enhancer starr_06156 Neighboring gene STARR-positive B cell enhancer ABC_E9537 Neighboring gene STARR-seq mESC enhancer starr_06157 Neighboring gene PHD finger protein 20 Neighboring gene STARR-seq mESC enhancer starr_06159 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156104477-156104678 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156113998-156114107

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine desulfurase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine desulfurase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables cysteine desulfurase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of iron-sulfur cluster assembly complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of mitochondrial [2Fe-2S] assembly complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mitochondrial [2Fe-2S] assembly complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cysteine desulfurase
    Names
    cysteine desulfurase, mitochondrial
    nifS-like (sic)
    nitrogen fixation gene, yeast homolog 1
    NP_001407367.1
    NP_001407368.1
    NP_001407369.1
    NP_035041.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420438.1NP_001407367.1  cysteine desulfurase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL833786, BX649640
      UniProtKB/TrEMBL
      Q921V3
    2. NM_001420439.1NP_001407368.1  cysteine desulfurase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL833786, BX649640
    3. NM_001420440.1NP_001407369.1  cysteine desulfurase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL833786, BX649640
      UniProtKB/TrEMBL
      A6QRH3
      Related
      ENSMUSP00000105229.2, ENSMUST00000109600.2
    4. NM_010911.3NP_035041.2  cysteine desulfurase isoform 1

      See identical proteins and their annotated locations for NP_035041.2

      Status: VALIDATED

      Source sequence(s)
      AL833786, BX649640
      Consensus CDS
      CCDS16962.1
      UniProtKB/Swiss-Prot
      Q8C6I5, Q9Z1J3
      UniProtKB/TrEMBL
      Q921V3
      Related
      ENSMUSP00000029147.10, ENSMUST00000029147.16
      Conserved Domains (2) summary
      PRK14012
      Location:60459
      PRK14012; cysteine desulfurase; Provisional
      pfam00266
      Location:62423
      Aminotran_5; Aminotransferase class-V

    RNA

    1. NR_185175.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL833786, BX649640

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155965569..155986106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)