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    Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [ Mus musculus (house mouse) ]

    Gene ID: 18033, updated on 15-Jul-2024

    Summary

    Official Symbol
    Nfkb1provided by MGI
    Official Full Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105provided by MGI
    Primary source
    MGI:MGI:97312
    See related
    Ensembl:ENSMUSG00000028163 AllianceGenome:MGI:97312
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p50; p105; NF-KB1; p50/p105; NF-kappaB; NF-kappaB1
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin binding activity; and identical protein binding activity. Involved in JNK cascade; cellular response to virus; and negative regulation of cytokine production. Acts upstream of or within several processes, including cellular response to dsRNA; cellular response to tumor necrosis factor; and regulation of gene expression. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen adult (RPKM 34.6), lung adult (RPKM 23.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nfkb1 in Genome Data Viewer
    Location:
    3 G3; 3 62.82 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (135290416..135397422, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135584655..135691969, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30992 Neighboring gene mannosidase, beta A, lysosomal Neighboring gene STARR-seq mESC enhancer starr_09062 Neighboring gene ornithine decarboxylase antizyme 2, pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135244702-135244889 Neighboring gene STARR-positive B cell enhancer ABC_E10216 Neighboring gene STARR-positive B cell enhancer ABC_E829 Neighboring gene STARR-positive B cell enhancer ABC_E4597 Neighboring gene STARR-positive B cell enhancer ABC_E11220 Neighboring gene STARR-positive B cell enhancer ABC_E1267 Neighboring gene STARR-seq mESC enhancer starr_09070 Neighboring gene STARR-positive B cell enhancer ABC_E8806 Neighboring gene RIKEN cDNA 4933401H06 gene Neighboring gene solute carrier family 39 (metal ion transporter), member 8 Neighboring gene predicted gene, 31243 Neighboring gene predicted gene, 18330

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (6) 
    • Endonuclease-mediated (4) 
    • Gene trapped (1)  1 citation
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein sequestering activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in antibacterial innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to angiotensin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to brain-derived neurotrophic factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to carbohydrate stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cellular response to diterpene ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to glucoside ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-17 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to interleukin-6 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cellular response to peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chemokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lymph node development TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland involution IC
    Inferred by Curator
    more info
    PubMed 
    involved_in mammary gland involution IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of calcidiol 1-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in non-canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hyaluronan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription initiation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cytokine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within response to muscle stretch IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of NF-kappaB p50/p65 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NF-kappaB p50/p65 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear factor NF-kappa-B p105 subunit
    Names
    DNA-binding factor KBF1
    EBP-1
    NF kappaB1
    NF-kappa-B1 p84/NF-kappa-B1 p98
    NF-kappaB p50
    nuclear factor kappaB p50
    nuclear factor of kappa light chain gene enhancer in B-cells 1, p105
    p50 subunit of NF kappaB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410442.1NP_001397371.1  nuclear factor NF-kappa-B p105 subunit isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC101973, AC110164
    2. NM_008689.3NP_032715.2  nuclear factor NF-kappa-B p105 subunit isoform 1

      See identical proteins and their annotated locations for NP_032715.2

      Status: VALIDATED

      Source sequence(s)
      AC101973, AC110164
      Consensus CDS
      CCDS17858.1
      UniProtKB/Swiss-Prot
      B2RRQ6, P25799, Q3TZE8, Q3V2V6, Q6TDG8, Q75ZL1, Q80Y21, Q8C712
      Related
      ENSMUSP00000029812.8, ENSMUST00000029812.14
      Conserved Domains (8) summary
      cd07935
      Location:40241
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      cd00204
      Location:572701
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:248349
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:812886
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      pfam12796
      Location:582676
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:539598
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:666722
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:538575
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      135290416..135397422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501107.3XP_006501170.1  nuclear factor NF-kappa-B p105 subunit isoform X2

      Conserved Domains (5) summary
      cd01177
      Location:119220
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:683757
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:409446
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:453547
      Ank_2; Ankyrin repeats (3 copies)
      cl08275
      Location:1112
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)