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    Nfe2l1 nuclear factor, erythroid derived 2,-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 18023, updated on 9-Oct-2018

    Summary

    Official Symbol
    Nfe2l1provided by MGI
    Official Full Name
    nuclear factor, erythroid derived 2,-like 1provided by MGI
    Primary source
    MGI:MGI:99421
    See related
    Ensembl:ENSMUSG00000038615 Vega:OTTMUSG00000001635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NRF1; Lcrf1; TCF11; LCR-F1; TCF-11; AA408798; AW212678
    Summary
    This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases from the use of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 102.3), heart adult (RPKM 69.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nfe2l1 in Genome Data Viewer
    Location:
    11 D; 11 60.12 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (96817413..96829968, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (96678728..96691282, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene sorting nexin 11 Neighboring gene chromobox 1 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene Neighboring gene microRNA 152 Neighboring gene coatomer protein complex, subunit zeta 2 Neighboring gene uncharacterized LOC102641351 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II distal enhancer sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    endoplasmic reticulum membrane sensor NFE2L1; nuclear factor erythroid 2-related factor 1
    Names
    NF-E2-related factor 1
    NFE2-related factor 1
    locus control region-factor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130450.1NP_001123922.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 1

      See identical proteins and their annotated locations for NP_001123922.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 5 encode the same isoform.
      Source sequence(s)
      AK038187, BC043063, CN527202
      Consensus CDS
      CCDS25304.1
      UniProtKB/Swiss-Prot
      Q61985
      UniProtKB/TrEMBL
      Q3V3M1, Q6GTN8
      Related
      ENSMUSP00000128527.1, ENSMUST00000167149.7
      Conserved Domains (1) summary
      cd14720
      Location:620687
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    2. NM_001130451.1NP_001123923.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 2

      See identical proteins and their annotated locations for NP_001123923.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a downstream in-frame ATG, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 encode the same isoform.
      Source sequence(s)
      AK038187, CJ144781, CJ152359
      Consensus CDS
      CCDS48893.1
      UniProtKB/TrEMBL
      Q3V3M1
      Related
      ENSMUSP00000131585.1, ENSMUST00000169828.7
      Conserved Domains (1) summary
      cd14720
      Location:332399
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    3. NM_001130452.1NP_001123924.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 2

      See identical proteins and their annotated locations for NP_001123924.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a downstream in-frame ATG, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 encode the same isoform.
      Source sequence(s)
      AK038187, CJ152359
      Consensus CDS
      CCDS48893.1
      UniProtKB/TrEMBL
      Q3V3M1
      Conserved Domains (1) summary
      cd14720
      Location:332399
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    4. NM_001130453.1NP_001123925.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a distinct ATG, compared to variant 1. The encoded protein (isoform 3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK038187, AK148471, CF163519
      Consensus CDS
      CCDS48894.1
      UniProtKB/TrEMBL
      Q3UFI8, Q3V3M1
      Related
      ENSMUSP00000127804.1, ENSMUST00000167110.7
      Conserved Domains (1) summary
      cd14720
      Location:462529
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    5. NM_001130454.1NP_001123926.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 4

      See identical proteins and their annotated locations for NP_001123926.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a distinct ATG, compared to variant 1. The encoded protein (isoform 4) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK038187, AK148471
      UniProtKB/TrEMBL
      Q3UFI8, Q3V3M1
      Conserved Domains (1) summary
      cd14720
      Location:451518
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    6. NM_001361682.1NP_001348611.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AK038187, AL596384, CF163519, CJ151652
      Conserved Domains (1) summary
      cd14720
      Location:493560
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    7. NM_008686.3NP_032712.2  endoplasmic reticulum membrane sensor NFE2L1 isoform 1

      See identical proteins and their annotated locations for NP_032712.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 5 encode the same isoform.
      Source sequence(s)
      AK038187, AK152040, BC043063, BY301848
      Consensus CDS
      CCDS25304.1
      UniProtKB/Swiss-Prot
      Q61985
      UniProtKB/TrEMBL
      Q3U5L0, Q3V3M1, Q6GTN8
      Related
      ENSMUSP00000080467.5, ENSMUST00000081775.11
      Conserved Domains (1) summary
      cd14720
      Location:620687
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      96817413..96829968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248790.1XP_011247092.1  nuclear factor erythroid 2-related factor 1 isoform X1

      Conserved Domains (1) summary
      cd14720
      Location:493560
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
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