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    Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 18005, updated on 22-Mar-2019

    Summary

    Official Symbol
    Nek2provided by MGI
    Official Full Name
    NIMA (never in mitosis gene a)-related expressed kinase 2provided by MGI
    Primary source
    MGI:MGI:109359
    See related
    Ensembl:ENSMUSG00000026622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C77054; AA617254
    Expression
    Broad expression in testis adult (RPKM 25.4), CNS E11.5 (RPKM 10.9) and 15 other tissues See more
    Orthologs

    Genomic context

    See Nek2 in Genome Data Viewer
    Location:
    1 H6; 1 96.94 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (191821281..191833049)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (193645352..193656928)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene lysophosphatidylglycerol acyltransferase 1 Neighboring gene placenta-specific gene 8 protein-like Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene RIKEN cDNA 1700034H15 gene Neighboring gene solute carrier family 30 (zinc transporter), member 1 Neighboring gene predicted gene, 39742

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    blastocyst development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome separation ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of centriole-centriole cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic centrosome separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of mitotic centrosome separation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase Nek2
    Names
    NIMA - related expressed kinase 2
    NIMA-related expressed kinase 2
    NIMA-related kinase 2
    Nek2 kinase
    never in mitosis A-related kinase 2
    nimA-related protein kinase 2
    NP_035022.2
    XP_006497186.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010892.3NP_035022.2  serine/threonine-protein kinase Nek2

      See identical proteins and their annotated locations for NP_035022.2

      Status: VALIDATED

      Source sequence(s)
      AK147072, BC057576, CF738658
      Consensus CDS
      CCDS15623.1
      UniProtKB/Swiss-Prot
      O35942
      UniProtKB/TrEMBL
      Q6PFG1
      Related
      ENSMUSP00000027931.7, ENSMUST00000027931.7
      Conserved Domains (2) summary
      smart00220
      Location:8271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08217
      Location:7271
      STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      191821281..191833049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497123.3XP_006497186.1  serine/threonine-protein kinase Nek2 isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:8271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08217
      Location:7271
      STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2
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