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    Nek1 NIMA (never in mitosis gene a)-related expressed kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18004, updated on 12-Aug-2018

    Summary

    Official Symbol
    Nek1provided by MGI
    Official Full Name
    NIMA (never in mitosis gene a)-related expressed kinase 1provided by MGI
    Primary source
    MGI:MGI:97303
    See related
    Ensembl:ENSMUSG00000031644 Vega:OTTMUSG00000031430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    kat; D8Ertd790e
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.0), frontal lobe adult (RPKM 6.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nek1 in Genome Data Viewer
    Location:
    8 B3.1; 8 30.91 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (60993193..61131349)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (63472017..63609031)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene chloride channel, voltage-sensitive 3 Neighboring gene predicted gene, 18394 Neighboring gene RIKEN cDNA B230317F23 gene Neighboring gene SH3 domain containing ring finger 1 Neighboring gene RIKEN cDNA 1700001D01 gene Neighboring gene predicted gene, 40499

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC189817

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA damage response, detection of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    activation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction by protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stress-activated protein kinase signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase Nek1
    Names
    NIMA-related kinase 1
    NY-REN-55 antigen
    Nek1 serine/threonine- and tyrosine-specific protein kinase
    kidney, anemia and testis
    never in mitosis A-related kinase 1
    nimA-related protein kinase 1
    NP_001280566.1
    NP_001280567.1
    NP_001280568.1
    NP_780298.2
    XP_006509357.1
    XP_017168097.1
    XP_017168098.1
    XP_017168099.1
    XP_017168100.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293637.1NP_001280566.1  serine/threonine-protein kinase Nek1 isoform 1

      See identical proteins and their annotated locations for NP_001280566.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC159302, AK135564, AY850065, BC070443, CX237035
      Consensus CDS
      CCDS85541.1
      UniProtKB/Swiss-Prot
      P51954
      UniProtKB/TrEMBL
      B2RXX0, Q3UXI0
      Related
      ENSMUSP00000147809.1, OTTMUSP00000077359, ENSMUST00000211672.1, OTTMUST00000148962
      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    2. NM_001293638.1NP_001280567.1  serine/threonine-protein kinase Nek1 isoform 2

      See identical proteins and their annotated locations for NP_001280567.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC159302, AK135564, AY850065, BC070443, CX237035
      Consensus CDS
      CCDS80879.1
      UniProtKB/Swiss-Prot
      P51954
      UniProtKB/TrEMBL
      B7ZWK0, Q3UXI0
      Related
      ENSMUSP00000113932.1, OTTMUSP00000041279, ENSMUST00000120689.7, OTTMUST00000077869
      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    3. NM_001293639.1NP_001280568.1  serine/threonine-protein kinase Nek1 isoform 4

      See identical proteins and their annotated locations for NP_001280568.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three alternate in-frame exons, compared to variant 1. The encoded protein (isoform 4) is shorter, compared to isoform 1.
      Source sequence(s)
      AK135564, AY850065, BC070443, CX237035
      Consensus CDS
      CCDS85542.1
      UniProtKB/Swiss-Prot
      P51954
      UniProtKB/TrEMBL
      B2RXQ4, Q3UXI0
      Related
      ENSMUSP00000147258.1, OTTMUSP00000077358, ENSMUST00000211256.1, OTTMUST00000148961
      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    4. NM_175089.4NP_780298.2  serine/threonine-protein kinase Nek1 isoform 3

      See identical proteins and their annotated locations for NP_780298.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The encoded protein (isoform 3) is shorter, compared to isoform 1.
      Source sequence(s)
      AK135564, AY850065, BC070443, CX237035
      Consensus CDS
      CCDS40347.1
      UniProtKB/Swiss-Prot
      P51954
      UniProtKB/TrEMBL
      Q3UXI0
      Related
      ENSMUSP00000034065.7, OTTMUSP00000041278, ENSMUST00000034065.13, OTTMUST00000077868
      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      60993193..61131349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509294.2XP_006509357.1  serine/threonine-protein kinase Nek1 isoform X3

      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    2. XM_017312608.1XP_017168097.1  serine/threonine-protein kinase Nek1 isoform X1

      UniProtKB/TrEMBL
      B2RXX0
      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    3. XM_017312609.1XP_017168098.1  serine/threonine-protein kinase Nek1 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    4. XM_017312610.1XP_017168099.1  serine/threonine-protein kinase Nek1 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    5. XM_017312611.1XP_017168100.1  serine/threonine-protein kinase Nek1 isoform X5

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