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    Septin2 septin 2 [ Mus musculus (house mouse) ]

    Gene ID: 18000, updated on 23-Jun-2021

    Summary

    Official Symbol
    Septin2provided by MGI
    Official Full Name
    septin 2provided by MGI
    Primary source
    MGI:MGI:97298
    See related
    Ensembl:ENSMUSG00000026276 Ensembl:ENSMUSG00000116048
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sep; Nedd; Nedd5; Sept2; Nedd-5; AW208991; mKIAA0158
    Expression
    Ubiquitous expression in placenta adult (RPKM 64.8), bladder adult (RPKM 49.3) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Septin2 in Genome Data Viewer
    Location:
    1; 1 D
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93406671..93437455)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93478981..93509733)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (95375570..95406310)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene anoctamin 7 Neighboring gene high density lipoprotein (HDL) binding protein Neighboring gene predicted gene, 17415 Neighboring gene FERM, RhoGEF and pleckstrin domain protein 2 Neighboring gene predicted gene, 41920 Neighboring gene elongation factor RNA polymerase II-like 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables enzyme regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cytoskeleton-dependent cytokinesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein polymerization TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of L-glutamate import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in actomyosin contractile ring NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    part_of exocyst ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in microtubule cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in midbody TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor connecting cilium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of septin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of septin complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in sperm annulus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle microtubule TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    septin-2
    Names
    neural precursor cell expressed, developmentally down-regulated gene 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159717.1NP_001153189.1  septin-2 isoform a

      See identical proteins and their annotated locations for NP_001153189.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC108412, BB849650, CJ075082, D49382
      Consensus CDS
      CCDS15190.1
      UniProtKB/Swiss-Prot
      P42208
      Related
      ENSMUSP00000136366.2, ENSMUST00000179353.8
      Conserved Domains (1) summary
      pfam00735
      Location:35306
      Septin
    2. NM_001159718.1NP_001153190.1  septin-2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. This variant lacks full-length transcript support in mouse, but it is supported by partial mouse ESTs and by the full-length orangutan mRNA, CR860673.1.
      Source sequence(s)
      AC108412, BY330456, CJ075082, D49382
      UniProtKB/Swiss-Prot
      P42208
      UniProtKB/TrEMBL
      E9Q3V6
      Related
      ENSMUSP00000127276.2, ENSMUST00000172165.8
      Conserved Domains (1) summary
      pfam00735
      Location:1266
      Septin; Septin
    3. NM_001159719.1NP_001153191.1  septin-2 isoform a

      See identical proteins and their annotated locations for NP_001153191.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC108412, BY331262, D49382
      Consensus CDS
      CCDS15190.1
      UniProtKB/Swiss-Prot
      P42208
      Related
      ENSMUSP00000132850.2, ENSMUST00000168776.8
      Conserved Domains (1) summary
      pfam00735
      Location:35306
      Septin
    4. NM_010891.2NP_035021.1  septin-2 isoform a

      See identical proteins and their annotated locations for NP_035021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC108412, CJ075082, D49382
      Consensus CDS
      CCDS15190.1
      UniProtKB/Swiss-Prot
      P42208
      Related
      ENSMUSP00000027495.9, ENSMUST00000027495.15
      Conserved Domains (1) summary
      pfam00735
      Location:35306
      Septin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      93406671..93437455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529241.3XP_006529304.1  septin-2 isoform X2

      See identical proteins and their annotated locations for XP_006529304.1

      UniProtKB/Swiss-Prot
      P42208
      Conserved Domains (1) summary
      pfam00735
      Location:35306
      Septin
    2. XM_030252110.2XP_030107970.1  septin-2 isoform X2

      Conserved Domains (1) summary
      pfam00735
      Location:35306
      Septin
    3. XM_036162723.1XP_036018616.1  septin-2 isoform X2

      Conserved Domains (1) summary
      pfam00735
      Location:35306
      Septin
    4. XM_006529240.4XP_006529303.1  septin-2 isoform X1

      Conserved Domains (1) summary
      pfam00735
      Location:64343
      Septin
    5. XM_006529242.1XP_006529305.1  septin-2 isoform X2

      See identical proteins and their annotated locations for XP_006529305.1

      UniProtKB/Swiss-Prot
      P42208
      Conserved Domains (1) summary
      pfam00735
      Location:35306
      Septin
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