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    Sept2 septin 2 [ Mus musculus (house mouse) ]

    Gene ID: 18000, updated on 12-Aug-2018

    Summary

    Official Symbol
    Sept2provided by MGI
    Official Full Name
    septin 2provided by MGI
    Primary source
    MGI:MGI:97298
    See related
    Ensembl:ENSMUSG00000026276 Ensembl:ENSMUSG00000116048 Vega:OTTMUSG00000021857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nedd5; Nedd-5; AW208991; mKIAA0158
    Expression
    Ubiquitous expression in placenta adult (RPKM 64.8), bladder adult (RPKM 49.3) and 24 other tissues See more
    Orthologs

    Genomic context

    See Sept2 in Genome Data Viewer
    Location:
    1; 1 D
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (93478968..93509733)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (95375570..95406310)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene anoctamin 7 Neighboring gene high density lipoprotein (HDL) binding protein Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene FERM, RhoGEF and pleckstrin domain protein 2 Neighboring gene predicted gene, 41920 Neighboring gene elongation factor RNA polymerase II-like 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enzyme regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex scaffold activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoskeleton-dependent cytokinesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    protein polymerization TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of L-glutamate import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    septin ring assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    actomyosin contractile ring NAS
    Non-traceable Author Statement
    more info
    PubMed 
    axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    cell cortex TAS
    Traceable Author Statement
    more info
    PubMed 
    cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    ciliary membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cilium IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    exocyst ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    midbody TAS
    Traceable Author Statement
    more info
    PubMed 
    motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    photoreceptor connecting cilium ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    septin complex ISO
    Inferred from Sequence Orthology
    more info
     
    septin filament array IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sperm annulus ISO
    Inferred from Sequence Orthology
    more info
     
    spindle microtubule TAS
    Traceable Author Statement
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    septin-2
    Names
    neural precursor cell expressed, developmentally down-regulated gene 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159717.1NP_001153189.1  septin-2 isoform a

      See identical proteins and their annotated locations for NP_001153189.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC108412, BB849650, CJ075082, D49382
      Consensus CDS
      CCDS15190.1
      UniProtKB/Swiss-Prot
      P42208
      Related
      ENSMUSP00000136366.1, ENSMUST00000179353.7
      Conserved Domains (2) summary
      COG5019
      Location:15332
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:34306
      Septin; Septin
    2. NM_001159718.1NP_001153190.1  septin-2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. This variant lacks full-length transcript support in mouse, but it is supported by partial mouse ESTs and by the full-length orangutan mRNA, CR860673.1.
      Source sequence(s)
      AC108412, BY330456, CJ075082, D49382
      UniProtKB/Swiss-Prot
      P42208
      UniProtKB/TrEMBL
      E9Q3V6
      Related
      ENSMUSP00000127276.1, ENSMUST00000172165.7
      Conserved Domains (1) summary
      pfam00735
      Location:1266
      Septin; Septin
    3. NM_001159719.1NP_001153191.1  septin-2 isoform a

      See identical proteins and their annotated locations for NP_001153191.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC108412, BY331262, D49382
      Consensus CDS
      CCDS15190.1
      UniProtKB/Swiss-Prot
      P42208
      Related
      ENSMUSP00000132850.1, ENSMUST00000168776.7
      Conserved Domains (2) summary
      COG5019
      Location:15332
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:34306
      Septin; Septin
    4. NM_010891.2NP_035021.1  septin-2 isoform a

      See identical proteins and their annotated locations for NP_035021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC108412, CJ075082, D49382
      Consensus CDS
      CCDS15190.1
      UniProtKB/Swiss-Prot
      P42208
      Related
      ENSMUSP00000027495.8, OTTMUSP00000024480, ENSMUST00000027495.14, OTTMUST00000051865
      Conserved Domains (2) summary
      COG5019
      Location:15332
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:34306
      Septin; Septin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      93478968..93509733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247934.2XP_011246236.1  septin-2 isoform X1

      Conserved Domains (2) summary
      COG5019
      Location:49368
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:68340
      Septin; Septin
    2. XM_006529241.2XP_006529304.1  septin-2 isoform X3

      See identical proteins and their annotated locations for XP_006529304.1

      UniProtKB/Swiss-Prot
      P42208
      Conserved Domains (2) summary
      COG5019
      Location:15332
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:34306
      Septin; Septin
    3. XM_006529240.2XP_006529303.1  septin-2 isoform X2

      Conserved Domains (2) summary
      COG5019
      Location:45364
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:64336
      Septin; Septin
    4. XM_006529242.1XP_006529305.1  septin-2 isoform X3

      See identical proteins and their annotated locations for XP_006529305.1

      UniProtKB/Swiss-Prot
      P42208
      Conserved Domains (2) summary
      COG5019
      Location:15332
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:34306
      Septin; Septin
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