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    Nedd1 neural precursor cell expressed, developmentally down-regulated gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 17997, updated on 26-Sep-2022

    Summary

    Official Symbol
    Nedd1provided by MGI
    Official Full Name
    neural precursor cell expressed, developmentally down-regulated gene 1provided by MGI
    Primary source
    MGI:MGI:97293
    See related
    Ensembl:ENSMUSG00000019988 AllianceGenome:MGI:97293
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in protein localization to centrosome. Predicted to act upstream of or within microtubule depolymerization and regulation of establishment of protein localization. Located in apical part of cell; cytoplasm; and microtubule cytoskeleton. Is expressed in several structures, including duodenum epithelium; genitourinary system; lung; nervous system; and sensory organ. Orthologous to human NEDD1 (NEDD1 gamma-tubulin ring complex targeting factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.5), placenta adult (RPKM 4.7) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Nedd1 in Genome Data Viewer
    Location:
    10; 10 C2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (92520607..92559544, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (92684745..92722418, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene putative 60S ribosomal protein L37a Neighboring gene predicted gene, 31822 Neighboring gene predicted gene, 24241 Neighboring gene cilia and flagella associated protein 54 Neighboring gene predicted gene, 40739 Neighboring gene predicted gene, 32468

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within microtubule polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    part_of gamma-tubulin ring complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in pericentriolar material IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein NEDD1
    Names
    NEDD-1
    neural precursor cell expressed developmentally down-regulated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008682.2NP_032708.2  protein NEDD1

      See identical proteins and their annotated locations for NP_032708.2

      Status: VALIDATED

      Source sequence(s)
      AK153746, BC052430
      Consensus CDS
      CCDS24123.1
      UniProtKB/Swiss-Prot
      P33215, Q9CWK2
      Related
      ENSMUSP00000020163.7, ENSMUST00000020163.7
      Conserved Domains (3) summary
      COG2319
      Location:3314
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:24299
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:81117
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      92520607..92559544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155673.1XP_036011566.1  protein NEDD1 isoform X1

      Conserved Domains (2) summary
      cd00200
      Location:63338
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:120156
      7WD40; WD40 repeat [structural motif]