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    Ncoa3 nuclear receptor coactivator 3 [ Mus musculus (house mouse) ]

    Gene ID: 17979, updated on 12-Sep-2021

    Summary

    Official Symbol
    Ncoa3provided by MGI
    Official Full Name
    nuclear receptor coactivator 3provided by MGI
    Primary source
    MGI:MGI:1276535
    See related
    Ensembl:ENSMUSG00000027678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p; AI; RA; Sr; TRA; Actr; Aib1; Rac3; Src3; TRAM; pCip; KAT13; Tram1; p/Cip; KAT13B; Tram-1; bHLHe4; bHLHe42; AW321064; 2010305B15Rik
    Expression
    Ubiquitous expression in spleen adult (RPKM 20.4), thymus adult (RPKM 16.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ncoa3 in Genome Data Viewer
    Location:
    2; 2 H3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165834557..165915162)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165992637..166073242)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (165818137..165898742)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 11462 Neighboring gene pluripotency associated transcript 29 Neighboring gene VISTA enhancer mm1346 Neighboring gene sulfatase 2 Neighboring gene predicted gene, 52534 Neighboring gene predicted gene, 30320

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nuclear receptor coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell dedifferentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to estradiol stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within labyrinthine layer morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland branching involved in thelarche IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular steroid hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within vagina development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear receptor coactivator 3
    Names
    AIB-1
    CBP-interacting protein
    NCoA-3
    RAC-3
    SRC-3
    amplified in breast cancer-1 protein homolog
    receptor-associated coactivator 3
    steroid receptor coactivator protein 3
    thyroid hormone receptor activator molecule 1
    NP_001361708.1
    NP_032705.2
    XP_030104100.1
    XP_036015065.1
    XP_036015066.1
    XP_036015068.1
    XP_036015076.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374779.1NP_001361708.1  nuclear receptor coactivator 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589873, AL589902
      Consensus CDS
      CCDS89586.1
      Related
      ENSMUSP00000104875.2, ENSMUST00000109252.8
      Conserved Domains (9) summary
      smart00091
      Location:117172
      PAS; PAS domain
      pfam08815
      Location:10561103
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam09606
      Location:10941397
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07469
      Location:12691325
      DUF1518; Domain of unknown function (DUF1518)
      pfam08832
      Location:608696
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:262372
      PAS_11; PAS domain
      pfam16279
      Location:714801
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:451564
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      cl00081
      Location:33102
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    2. NM_008679.3NP_032705.2  nuclear receptor coactivator 3 isoform 1

      See identical proteins and their annotated locations for NP_032705.2

      Status: VALIDATED

      Source sequence(s)
      AL589873, BC093478, CJ101424
      Consensus CDS
      CCDS38333.1
      UniProtKB/TrEMBL
      A5D6Q2, Q05BA5
      Related
      ENSMUSP00000085416.6, ENSMUST00000088095.6
      Conserved Domains (9) summary
      smart00091
      Location:117172
      PAS; PAS domain
      pfam08815
      Location:10561103
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam09606
      Location:10941398
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07469
      Location:12701326
      DUF1518; Domain of unknown function (DUF1518)
      pfam08832
      Location:608696
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:262372
      PAS_11; PAS domain
      pfam16279
      Location:714801
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:451564
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      cl00081
      Location:33102
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      165834557..165915162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159183.1XP_036015076.1  nuclear receptor coactivator 3 isoform X4

      Conserved Domains (7) summary
      TIGR01628
      Location:10331201
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam07469
      Location:10701127
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:857903
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:409497
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:63173
      PAS_11; PAS domain
      pfam16279
      Location:515602
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:252365
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    2. XM_036159175.1XP_036015068.1  nuclear receptor coactivator 3 isoform X2

      Conserved Domains (8) summary
      TIGR01628
      Location:11141282
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      smart00091
      Location:354
      PAS; PAS domain
      pfam07469
      Location:11511208
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:938984
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:490578
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:144254
      PAS_11; PAS domain
      pfam16279
      Location:596683
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:333446
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    3. XM_036159172.1XP_036015065.1  nuclear receptor coactivator 3 isoform X1

      Conserved Domains (8) summary
      TIGR01628
      Location:11151283
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      smart00091
      Location:354
      PAS; PAS domain
      pfam07469
      Location:11521209
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:938984
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:490578
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:144254
      PAS_11; PAS domain
      pfam16279
      Location:596683
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:333446
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    4. XM_030248240.2XP_030104100.1  nuclear receptor coactivator 3 isoform X3

      Conserved Domains (7) summary
      pfam08815
      Location:857904
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam09606
      Location:8951199
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07469
      Location:10711127
      DUF1518; Domain of unknown function (DUF1518)
      pfam08832
      Location:409497
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:63173
      PAS_11; PAS domain
      pfam16279
      Location:515602
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:252365
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    5. XM_036159173.1XP_036015066.1  nuclear receptor coactivator 3 isoform X1

      Conserved Domains (8) summary
      TIGR01628
      Location:11151283
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      smart00091
      Location:354
      PAS; PAS domain
      pfam07469
      Location:11521209
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:938984
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:490578
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:144254
      PAS_11; PAS domain
      pfam16279
      Location:596683
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:333446
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
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