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    Ncoa2 nuclear receptor coactivator 2 [ Mus musculus (house mouse) ]

    Gene ID: 17978, updated on 2-Oct-2018

    Summary

    Official Symbol
    Ncoa2provided by MGI
    Official Full Name
    nuclear receptor coactivator 2provided by MGI
    Primary source
    MGI:MGI:1276533
    See related
    Ensembl:ENSMUSG00000005886 Vega:OTTMUSG00000021630
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TIF2; Grip1; SRC-2; GRIP-1; KAT13C; NCoA-2; bHLHe75; D1Ertd433e
    Expression
    Ubiquitous expression in testis adult (RPKM 10.9), thymus adult (RPKM 8.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ncoa2 in Genome Data Viewer
    Location:
    1 A3; 1 4.12 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (13139105..13374083, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (13129240..13364164, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39592 Neighboring gene PR domain containing 14 Neighboring gene predicted gene, 39595 Neighboring gene signal recognition particle receptor ('docking protein') pseudogene Neighboring gene predicted gene, 39600

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 9530095N19

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aryl hydrocarbon receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear receptor transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear receptor transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear receptor transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    progesterone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    retinoic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    thyroid hormone receptor coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to Thyroglobulin triiodothyronine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of female receptivity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucocorticoid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to progesterone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear receptor coactivator 2
    Names
    glucocorticoid receptor interacting protein 1
    steroid receptor coactivator 2
    transcriptional intermediary factor 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302702.1NP_001289631.1  nuclear receptor coactivator 2 isoform b

      See identical proteins and their annotated locations for NP_001289631.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) differs in the 5' UTR and lacks an in-frame exon compared to variant a. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC091248, AK028964, AK035719, AK038781, AK042893, AK087443, BP761474, BU703942
      Consensus CDS
      CCDS35514.1
      UniProtKB/TrEMBL
      E9PV80, Q8BN74, Q8C961, Q8CAG7, Q8CBM5, Q8CE59
      Related
      ENSMUSP00000080413.4, OTTMUSP00000024144, ENSMUST00000081713.10, OTTMUST00000051358
      Conserved Domains (8) summary
      smart00353
      Location:3588
      HLH; helix loop helix domain
      smart00091
      Location:118175
      PAS; PAS domain
      pfam07469
      Location:12101267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10021047
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    2. NM_008678.3NP_032704.2  nuclear receptor coactivator 2 isoform a

      See identical proteins and their annotated locations for NP_032704.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC091248, AK028964, AK035719, AK038781, AK042893, AK052117, AK087443, BP761474, BU703942
      Consensus CDS
      CCDS35515.1
      UniProtKB/Swiss-Prot
      Q61026
      UniProtKB/TrEMBL
      Q8BN74, Q8C961, Q8CAG7, Q8CBM5, Q8CE59
      Related
      ENSMUSP00000006037.6, OTTMUSP00000024153, ENSMUST00000006037.12, OTTMUST00000051367
      Conserved Domains (8) summary
      smart00353
      Location:3588
      HLH; helix loop helix domain
      smart00091
      Location:118175
      PAS; PAS domain
      pfam07469
      Location:12791336
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10711116
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      13139105..13374083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238351.2XP_011236653.1  nuclear receptor coactivator 2 isoform X3

      See identical proteins and their annotated locations for XP_011236653.1

      Conserved Domains (8) summary
      smart00353
      Location:3588
      HLH; helix loop helix domain
      smart00091
      Location:118175
      PAS; PAS domain
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761121
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    2. XM_011238361.2XP_011236663.1  nuclear receptor coactivator 2 isoform X7

      See identical proteins and their annotated locations for XP_011236663.1

      UniProtKB/TrEMBL
      E9PV80
      Related
      ENSMUSP00000069509.6, ENSMUST00000068304.12
      Conserved Domains (8) summary
      smart00353
      Location:3588
      HLH; helix loop helix domain
      smart00091
      Location:118175
      PAS; PAS domain
      pfam07469
      Location:12101267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10021047
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    3. XM_006495465.3XP_006495528.1  nuclear receptor coactivator 2 isoform X4

      See identical proteins and their annotated locations for XP_006495528.1

      UniProtKB/Swiss-Prot
      Q61026
      Conserved Domains (8) summary
      smart00353
      Location:3588
      HLH; helix loop helix domain
      smart00091
      Location:118175
      PAS; PAS domain
      pfam07469
      Location:12791336
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10711116
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:640709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    4. XM_017319241.1XP_017174730.1  nuclear receptor coactivator 2 isoform X5

    5. XM_017319243.1XP_017174732.1  nuclear receptor coactivator 2 isoform X6

    6. XM_017319237.1XP_017174726.1  nuclear receptor coactivator 2 isoform X2

    7. XM_017319229.1XP_017174718.1  nuclear receptor coactivator 2 isoform X1

    8. XM_017319234.1XP_017174723.1  nuclear receptor coactivator 2 isoform X1

    9. XM_017319231.1XP_017174720.1  nuclear receptor coactivator 2 isoform X1

    10. XM_017319235.1XP_017174724.1  nuclear receptor coactivator 2 isoform X1

    11. XM_017319233.1XP_017174722.1  nuclear receptor coactivator 2 isoform X1

    12. XM_017319232.1XP_017174721.1  nuclear receptor coactivator 2 isoform X1

    13. XM_017319230.1XP_017174719.1  nuclear receptor coactivator 2 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001077695.1: Suppressed sequence

      Description
      NM_001077695.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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