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    Ncoa2 nuclear receptor coactivator 2 [ Mus musculus (house mouse) ]

    Gene ID: 17978, updated on 25-Nov-2021

    Summary

    Official Symbol
    Ncoa2provided by MGI
    Official Full Name
    nuclear receptor coactivator 2provided by MGI
    Primary source
    MGI:MGI:1276533
    See related
    Ensembl:ENSMUSG00000005886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TIF2; Grip1; SRC-2; GRIP-1; KAT13C; NCoA-2; bHLHe75; D1Ertd433e
    Expression
    Ubiquitous expression in testis adult (RPKM 10.9), thymus adult (RPKM 8.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ncoa2 in Genome Data Viewer
    Location:
    1 A3; 1 4.12 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (13209329..13444451, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (13139105..13374227, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (13129240..13364164, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39592 Neighboring gene PR domain containing 14 Neighboring gene predicted gene, 23169 Neighboring gene predicted gene, 51852 Neighboring gene predicted gene, 39595 Neighboring gene signal recognition particle receptor ('docking protein') pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 9530095N19

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables aryl hydrocarbon receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nuclear receptor coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables progesterone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables retinoic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to Thyroglobulin triiodothyronine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of female receptivity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glucocorticoid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to progesterone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear receptor coactivator 2
    Names
    glucocorticoid receptor interacting protein 1
    steroid receptor coactivator 2
    transcriptional intermediary factor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302702.1NP_001289631.1  nuclear receptor coactivator 2 isoform b

      See identical proteins and their annotated locations for NP_001289631.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) differs in the 5' UTR and lacks an in-frame exon compared to variant a. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC091248, AK028964, AK035719, AK038781, AK042893, AK087443, BP761474, BU703942
      Consensus CDS
      CCDS35514.1
      UniProtKB/TrEMBL
      E9PV80, Q8BN74, Q8C961, Q8CAG7, Q8CBM5, Q8CE59
      Related
      ENSMUSP00000080413.5, ENSMUST00000081713.11
      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:10561334
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12101267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10021046
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    2. NM_008678.3NP_032704.2  nuclear receptor coactivator 2 isoform a

      See identical proteins and their annotated locations for NP_032704.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC091248, AK028964, AK035719, AK038781, AK042893, AK052117, AK087443, BP761474, BU703942
      Consensus CDS
      CCDS35515.1
      UniProtKB/Swiss-Prot
      Q61026
      UniProtKB/TrEMBL
      Q8BN74, Q8C961, Q8CAG7, Q8CBM5, Q8CE59
      Related
      ENSMUSP00000006037.7, ENSMUST00000006037.13
      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:9211424
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12791336
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10711115
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      13209329..13444451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162692.1XP_036018585.1  nuclear receptor coactivator 2 isoform X4

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:9211424
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12791336
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10711115
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    2. XM_036162710.1XP_036018603.1  nuclear receptor coactivator 2 isoform X7

      Related
      ENSMUSP00000069509.7, ENSMUST00000068304.13
      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:10561334
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12101267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10021046
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    3. XM_030252088.1XP_030107948.1  nuclear receptor coactivator 2 isoform X3

      Conserved Domains (8) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam08815
      Location:10761121
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam07469
      Location:12841340
      DUF1518; Domain of unknown function (DUF1518)
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    4. XM_036162655.1XP_036018548.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    5. XM_030252095.2XP_030107955.1  nuclear receptor coactivator 2 isoform X7

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:10561334
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12101267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10021046
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    6. XM_036162694.1XP_036018587.1  nuclear receptor coactivator 2 isoform X4

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:9211424
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12791336
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10711115
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    7. XM_036162714.1XP_036018607.1  nuclear receptor coactivator 2 isoform X7

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:10561334
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12101267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10021046
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    8. XM_036162698.1XP_036018591.1  nuclear receptor coactivator 2 isoform X4

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:9211424
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12791336
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10711115
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    9. XM_036162703.1XP_036018596.1  nuclear receptor coactivator 2 isoform X6

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:10561334
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12101267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10021046
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    10. XM_030252090.2XP_030107950.1  nuclear receptor coactivator 2 isoform X5

      Conserved Domains (10) summary
      TIGR01628
      Location:9021021
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      smart00091
      Location:118175
      PAS; PAS domain
      pfam08815
      Location:10071052
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam09606
      Location:10701360
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07469
      Location:12151271
      DUF1518; Domain of unknown function (DUF1518)
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    11. XM_030252087.2XP_030107947.1  nuclear receptor coactivator 2 isoform X2

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam08815
      Location:10711116
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam09606
      Location:9211424
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07469
      Location:12791335
      DUF1518; Domain of unknown function (DUF1518)
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    12. XM_030252072.2XP_030107932.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    13. XM_030252093.2XP_030107953.1  nuclear receptor coactivator 2 isoform X6

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:10561334
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12101267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10021046
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    14. XM_017319241.3XP_017174730.1  nuclear receptor coactivator 2 isoform X5

      Conserved Domains (10) summary
      TIGR01628
      Location:9021021
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      smart00091
      Location:118175
      PAS; PAS domain
      pfam08815
      Location:10071052
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam09606
      Location:10701360
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07469
      Location:12151271
      DUF1518; Domain of unknown function (DUF1518)
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    15. XM_017319229.3XP_017174718.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    16. XM_030252082.2XP_030107942.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    17. XM_030252068.2XP_030107928.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    18. XM_017319235.3XP_017174724.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    19. XM_036162665.1XP_036018558.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    20. XM_036162709.1XP_036018602.1  nuclear receptor coactivator 2 isoform X6

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:10561334
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12101267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10021046
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    21. XM_017319233.3XP_017174722.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    22. XM_030252070.2XP_030107930.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    23. XM_017319232.3XP_017174721.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    24. XM_030252066.2XP_030107926.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    25. XM_036162671.1XP_036018564.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    26. XM_036162677.1XP_036018570.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    27. XM_030252075.2XP_030107935.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    28. XM_030252077.2XP_030107937.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    29. XM_030252083.2XP_030107943.1  nuclear receptor coactivator 2 isoform X1

      Conserved Domains (9) summary
      smart00091
      Location:118175
      PAS; PAS domain
      pfam09606
      Location:11301408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:2891
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:12841341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10761120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268378
      PAS_11; PAS domain
      pfam16279
      Location:731816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001077695.1: Suppressed sequence

      Description
      NM_001077695.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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