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    Nck1 non-catalytic region of tyrosine kinase adaptor protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 17973, updated on 28-Aug-2018

    Summary

    Official Symbol
    Nck1provided by MGI
    Official Full Name
    non-catalytic region of tyrosine kinase adaptor protein 1provided by MGI
    Primary source
    MGI:MGI:109601
    See related
    Ensembl:ENSMUSG00000032475 Vega:OTTMUSG00000021049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nck; Nck-1; 6330586M15Rik; D230010O13Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 10.7), placenta adult (RPKM 9.3) and 24 other tissues See more
    Orthologs

    Genomic context

    See Nck1 in Genome Data Viewer
    Location:
    9; 9 E3.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (100494302..100546134, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (100395422..100446472, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene 28166 Neighboring gene interleukin 20 receptor beta Neighboring gene predicted gene, 46139 Neighboring gene solute carrier family 35, member G2 Neighboring gene stromal antigen 1 Neighboring gene predicted gene 8661

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH3/SH2 adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    eukaryotic initiation factor eIF2 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    eukaryotic initiation factor eIF2 binding ISO
    Inferred from Sequence Orthology
    more info
     
    molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ephrin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of PERK-mediated unfolded protein response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of PERK-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of actin filament polymerization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cap-dependent translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cap-independent translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation in response to endoplasmic reticulum stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of translation in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    response to other organism IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    substrate-dependent cell migration, cell extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphatase type 1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cytoplasmic protein NCK1
    Names
    NCK adaptor protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324530.1NP_001311459.1  cytoplasmic protein NCK1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a distinct promoter and therefore has a distinct 5' UTR and 5' coding region, compared to variant 1. This variant encodes isoform 2 which, compared to isoform 1, lacks an N-terminal SH3 domain.
      Source sequence(s)
      AK053155, AK054051
      Consensus CDS
      CCDS85715.1
      UniProtKB/TrEMBL
      Q8BH99
      Related
      ENSMUSP00000108495.3, OTTMUSP00000023125, ENSMUST00000112874.3, OTTMUST00000049789
      Conserved Domains (3) summary
      cd10408
      Location:216312
      SH2_Nck1; Src homology 2 (SH2) domain found in Nck
      cd11901
      Location:4498
      SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
      cd11904
      Location:129185
      SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
    2. NM_010878.3NP_035008.2  cytoplasmic protein NCK1 isoform 1

      See identical proteins and their annotated locations for NP_035008.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK053155, BY096444, CJ171968
      Consensus CDS
      CCDS23440.1
      UniProtKB/Swiss-Prot
      Q99M51
      UniProtKB/TrEMBL
      Q8BH99
      Related
      ENSMUSP00000112221.1, OTTMUSP00000023124, ENSMUST00000116522.7, OTTMUST00000049788
      Conserved Domains (4) summary
      cd10408
      Location:280376
      SH2_Nck1; Src homology 2 (SH2) domain found in Nck
      cd11900
      Location:361
      SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
      cd11901
      Location:108162
      SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
      cd11904
      Location:193249
      SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      100494302..100546134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510840.2XP_006510903.1  cytoplasmic protein NCK1 isoform X1

      See identical proteins and their annotated locations for XP_006510903.1

      UniProtKB/Swiss-Prot
      Q99M51
      Conserved Domains (4) summary
      cd10408
      Location:280376
      SH2_Nck1; Src homology 2 (SH2) domain found in Nck
      cd11900
      Location:361
      SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
      cd11901
      Location:108162
      SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
      cd11904
      Location:193249
      SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
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