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    DOK1 docking protein 1 [ Homo sapiens (human) ]

    Gene ID: 1796, updated on 11-Apr-2024

    Summary

    Official Symbol
    DOK1provided by HGNC
    Official Full Name
    docking protein 1provided by HGNC
    Primary source
    HGNC:HGNC:2990
    See related
    Ensembl:ENSG00000115325 MIM:602919; AllianceGenome:HGNC:2990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    pp62; P62DOK
    Summary
    The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
    Expression
    Ubiquitous expression in fat (RPKM 6.6), spleen (RPKM 6.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    2p13.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (74549105..74557551)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (74557671..74566117)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74776232..74784678)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16070 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74756279-74757161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16073 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16075 Neighboring gene DEAQ-box RNA dependent ATPase 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:74763605-74764106 Neighboring gene AUP1 lipid droplet regulating VLDL assembly factor Neighboring gene HtrA serine peptidase 2 Neighboring gene lysyl oxidase like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11669 Neighboring gene Sharpr-MPRA regulatory regions 4995 and 13004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74781947-74782464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16079 Neighboring gene meiosis 1 associated protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16081 Neighboring gene TOR1B pseudogene 1 Neighboring gene TVP23B pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with docking protein 1 (DOK1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC117395, MGC138860

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in macrophage colony-stimulating factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    docking protein 1
    Names
    Downstream of tyrosine kinase 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050617.1 RefSeqGene

      Range
      11516..14347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001197260.2NP_001184189.1  docking protein 1 isoform b

      See identical proteins and their annotated locations for NP_001184189.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b, also known as 2) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AF035299, BQ575925, DA382785
      Consensus CDS
      CCDS56125.1
      UniProtKB/Swiss-Prot
      Q99704
      Related
      ENSP00000387016.1, ENST00000409429.5
      Conserved Domains (1) summary
      cd01203
      Location:12114
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    2. NM_001318866.2NP_001305795.1  docking protein 1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AK055944, AK314678, BQ575925
      Consensus CDS
      CCDS56125.1
      UniProtKB/TrEMBL
      B3KP83
      Conserved Domains (1) summary
      cd01203
      Location:12114
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    3. NM_001318867.2NP_001305796.1  docking protein 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AK055944, AK296154, BQ575925
      UniProtKB/TrEMBL
      B3KP83, B4DJN1, Q53GP8
      Conserved Domains (3) summary
      cd01203
      Location:140242
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      pfam00169
      Location:8105
      PH; PH domain
      cl17171
      Location:11108
      PH-like; Pleckstrin homology-like domain
    4. NM_001318868.2NP_001305797.1  docking protein 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC005033, AK055944, BC111055, BQ575925
      Consensus CDS
      CCDS82474.1
      UniProtKB/Swiss-Prot
      Q99704
      UniProtKB/TrEMBL
      B3KP83, Q2TA81
      Related
      ENSP00000344330.6, ENST00000340004.6
      Conserved Domains (1) summary
      cl17171
      Location:6119
      PH-like; Pleckstrin homology-like domain
    5. NM_001318869.2NP_001305798.1  docking protein 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC005033, AK055944, BC114497, BQ575925
      UniProtKB/TrEMBL
      Q14CB2, Q2TA81
      Conserved Domains (1) summary
      cl17171
      Location:139
      PH-like; Pleckstrin homology-like domain
    6. NM_001381.5NP_001372.1  docking protein 1 isoform a

      See identical proteins and their annotated locations for NP_001372.1

      Status: REVIEWED

      Source sequence(s)
      AC005033, AK055944, BQ575925
      Consensus CDS
      CCDS1954.1
      UniProtKB/Swiss-Prot
      O43204, Q53TY2, Q99704, Q9UHG6
      UniProtKB/TrEMBL
      B3KP83, Q53GP8
      Related
      ENSP00000233668.5, ENST00000233668.10
      Conserved Domains (2) summary
      cd01203
      Location:151253
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:6119
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      74549105..74557551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      74557671..74566117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)