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    Ppp1r12a protein phosphatase 1, regulatory subunit 12A [ Mus musculus (house mouse) ]

    Gene ID: 17931, updated on 6-Sep-2021

    Summary

    Official Symbol
    Ppp1r12aprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 12Aprovided by MGI
    Primary source
    MGI:MGI:1309528
    See related
    Ensembl:ENSMUSG00000019907
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mypt; Mypt1; AA792106; AV099298; D10Ertd625; D10Ertd625e; 1200015F06Rik; 5730577I22Rik
    Expression
    Biased expression in bladder adult (RPKM 144.2), CNS E11.5 (RPKM 14.0) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ppp1r12a in Genome Data Viewer
    Location:
    10 D1; 10 56.33 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (107997913..108115846)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (108162092..108279985)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (107599456..107714631)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene otogelin-like Neighboring gene predicted gene, 29685 Neighboring gene PRKC, apoptosis, WT1, regulator Neighboring gene predicted gene, 23105 Neighboring gene predicted gene, 36283 Neighboring gene predicted gene, 36440

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC159084

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in A band IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in A band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of PTW/PP1 phosphatase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in contractile fiber ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory subunit 12A
    Names
    myosin phosphatase target subunit 1
    myosin phosphatase-targeting subunit 1
    protein phosphatase 1, regulatory (inhibitor) subunit 12A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368736.1NP_001355665.1  protein phosphatase 1 regulatory subunit 12A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC139335
      Consensus CDS
      CCDS88083.1
      Related
      ENSMUSP00000151842.2, ENSMUST00000219263.2
      Conserved Domains (4) summary
      PHA03095
      Location:43272
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:9301028
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
    2. NM_001368737.1NP_001355666.1  protein phosphatase 1 regulatory subunit 12A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC139335
      Conserved Domains (4) summary
      PHA03095
      Location:43272
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:874972
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
    3. NM_027892.3NP_082168.1  protein phosphatase 1 regulatory subunit 12A isoform 2

      See identical proteins and their annotated locations for NP_082168.1

      Status: VALIDATED

      Source sequence(s)
      AC139335
      Consensus CDS
      CCDS36052.1
      UniProtKB/Swiss-Prot
      Q9DBR7
      Related
      ENSMUSP00000069257.6, ENSMUST00000070663.6
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:930984
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      107997913..108115846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513329.5XP_006513392.1  protein phosphatase 1 regulatory subunit 12A isoform X2

      See identical proteins and their annotated locations for XP_006513392.1

      Conserved Domains (3) summary
      PHA03095
      Location:43272
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
      pfam15898
      Location:873971
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
    2. XM_006513327.5XP_006513390.1  protein phosphatase 1 regulatory subunit 12A isoform X1

      Conserved Domains (3) summary
      PHA03095
      Location:43272
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
      pfam15898
      Location:930984
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
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