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    Ppp1r12a protein phosphatase 1, regulatory subunit 12A [ Mus musculus (house mouse) ]

    Gene ID: 17931, updated on 9-Sep-2018

    Summary

    Official Symbol
    Ppp1r12aprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 12Aprovided by MGI
    Primary source
    MGI:MGI:1309528
    See related
    Ensembl:ENSMUSG00000019907
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mypt1; AA792106; AV099298; D10Ertd625e; 1200015F06Rik; 5730577I22Rik
    Expression
    Biased expression in bladder adult (RPKM 144.2), CNS E11.5 (RPKM 14.0) and 11 other tissues See more
    Orthologs

    Genomic context

    See Ppp1r12a in Genome Data Viewer
    Location:
    10 D1; 10 56.33 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (108161831..108279833)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (107599456..107714631)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 29685 Neighboring gene predicted gene, 40754 Neighboring gene predicted gene, 40755 Neighboring gene PRKC, apoptosis, WT1, regulator Neighboring gene predicted gene, 36283 Neighboring gene predicted gene, 36440

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC159084

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of myosin-light-chain-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of myosin-light-chain-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of myosin-light-chain-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of nucleocytoplasmic transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    A band IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    A band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    PTW/PP1 phosphatase complex ISO
    Inferred from Sequence Orthology
    more info
     
    Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    contractile fiber ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory subunit 12A
    Names
    myosin phosphatase target subunit 1
    myosin phosphatase-targeting subunit 1
    protein phosphatase 1, regulatory (inhibitor) subunit 12A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027892.2NP_082168.1  protein phosphatase 1 regulatory subunit 12A

      See identical proteins and their annotated locations for NP_082168.1

      Status: PROVISIONAL

      Source sequence(s)
      AK004785
      Consensus CDS
      CCDS36052.1
      UniProtKB/Swiss-Prot
      Q9DBR7
      Related
      ENSMUSP00000069257.5, ENSMUST00000070663.5
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:930984
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      108161831..108279833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513327.3XP_006513390.1  protein phosphatase 1 regulatory subunit 12A isoform X2

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:930984
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    2. XM_006513329.3XP_006513392.1  protein phosphatase 1 regulatory subunit 12A isoform X4

      See identical proteins and their annotated locations for XP_006513392.1

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:873971
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    3. XM_006513328.3XP_006513391.1  protein phosphatase 1 regulatory subunit 12A isoform X3

      See identical proteins and their annotated locations for XP_006513391.1

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:874972
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    4. XM_006513326.3XP_006513389.1  protein phosphatase 1 regulatory subunit 12A isoform X1

      See identical proteins and their annotated locations for XP_006513389.1

      UniProtKB/Swiss-Prot
      Q9DBR7
      Related
      ENSMUSP00000151842.1, ENSMUST00000219263.1
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9301028
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
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