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    Myo5b myosin VB [ Mus musculus (house mouse) ]

    Gene ID: 17919, updated on 5-Sep-2021

    Summary

    Official Symbol
    Myo5bprovided by MGI
    Official Full Name
    myosin VBprovided by MGI
    Primary source
    MGI:MGI:106598
    See related
    Ensembl:ENSMUSG00000025885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI661750; mKIAA1119
    Expression
    Broad expression in large intestine adult (RPKM 24.0), genital fat pad adult (RPKM 20.9) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Myo5b in Genome Data Viewer
    Location:
    18 E2; 18 50.7 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (74575435..74905769)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (74442364..74772698)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (74602273..74931131)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S11 pseudogene Neighboring gene predicted gene 8987 Neighboring gene RIKEN cDNA 1700120E14 gene Neighboring gene predicted gene, 33090 Neighboring gene predicted gene, 52349 Neighboring gene predicted gene, 52348 Neighboring gene small Cajal body-specific RNA 17 Neighboring gene predicted gene, 41774 Neighboring gene predicted gene, 23119

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter receptor transport, endosome to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of modification of postsynaptic structure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle transport along actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in apical cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    unconventional myosin-Vb
    Names
    myosin-Vb

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201600.2NP_963894.1  unconventional myosin-Vb

      See identical proteins and their annotated locations for NP_963894.1

      Status: VALIDATED

      Source sequence(s)
      AC147992, AC148001, AC148002, AK033484, BQ557090, BU610647, BY245557, CD352410, CF741517, CJ052777, CV558709, DV655888
      Consensus CDS
      CCDS37858.1
      UniProtKB/TrEMBL
      G5E8G6
      Related
      ENSMUSP00000073790.7, ENSMUST00000074157.13
      Conserved Domains (8) summary
      smart00015
      Location:861881
      IQ; Calmodulin-binding motif
      smart00242
      Location:64761
      MYSc; Myosin. Large ATPases
      COG4942
      Location:11451435
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd15477
      Location:14441815
      Myo5b_CBD; Cargo binding domain of myosin 5b
      cd01380
      Location:83750
      MYSc_Myo5; class V myosin, motor domain
      pfam07956
      Location:901993
      DUF1690; Protein of Unknown function (DUF1690)
      pfam08614
      Location:9791208
      ATG16; Autophagy protein 16 (ATG16)
      cl23720
      Location:9701060
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      74575435..74905769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525714.4XP_006525777.1  unconventional myosin-Vb isoform X1

      Conserved Domains (4) summary
      COG4942
      Location:11361449
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      COG5022
      Location:111268
      COG5022; Myosin heavy chain [General function prediction only]
      cd15477
      Location:14751846
      Myo5b_CBD; Cargo binding domain of myosin 5b
      cd01380
      Location:83750
      MYSc_Myo5; class V myosin, motor domain
    2. XM_006525715.5XP_006525778.1  unconventional myosin-Vb isoform X2

      Conserved Domains (4) summary
      COG4942
      Location:11581448
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      COG5022
      Location:191276
      COG5022; Myosin heavy chain [General function prediction only]
      cd15477
      Location:14571828
      Myo5b_CBD; Cargo binding domain of myosin 5b
      cd01380
      Location:91758
      MYSc_Myo5; class V myosin, motor domain
    3. XM_006525716.4XP_006525779.1  unconventional myosin-Vb isoform X3

      Conserved Domains (4) summary
      COG4942
      Location:11531443
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      COG5022
      Location:191271
      COG5022; Myosin heavy chain [General function prediction only]
      cd15477
      Location:14521823
      Myo5b_CBD; Cargo binding domain of myosin 5b
      cd01380
      Location:91758
      MYSc_Myo5; class V myosin, motor domain
    4. XM_036161024.1XP_036016917.1  unconventional myosin-Vb isoform X4

      Conserved Domains (2) summary
      COG0419
      Location:25576
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd15477
      Location:561932
      Myo5b_CBD; Cargo binding domain of myosin 5b

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_008661.2: Suppressed sequence

      Description
      NM_008661.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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