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    Myo1c myosin IC [ Mus musculus (house mouse) ]

    Gene ID: 17913, updated on 5-Sep-2021

    Summary

    Official Symbol
    Myo1cprovided by MGI
    Official Full Name
    myosin ICprovided by MGI
    Primary source
    MGI:MGI:106612
    See related
    Ensembl:ENSMUSG00000017774
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NMI; myr; MMIb; myr2; MYO1E; C80397; mm1bet; mm1beta
    Summary
    This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The protein functions in intracellular vesicle transport to the plasma membrane. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lung adult (RPKM 70.4), subcutaneous fat pad adult (RPKM 51.1) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Myo1c in Genome Data Viewer
    Location:
    11 B5; 11 45.92 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75541345..75565469)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75650519..75674643)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (75465011..75488145)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transfer protein, alpha Neighboring gene cytochrome c oxidase, subunit VIIc pseudogene Neighboring gene inositol polyphosphate 5-phosphatase K Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog Neighboring gene uncharacterized LOC118567335 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables actin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microfilament motor activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration by vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle transport along actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within vesicle transport along actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of filamentous actin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stereocilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stereocilium bundle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    unconventional myosin-Ic
    Names
    MMI-beta
    myosin I beta
    myosin-Ibeta
    myosin-Ic
    nuclear myosin I beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080774.1NP_001074243.1  unconventional myosin-Ic isoform b

      See identical proteins and their annotated locations for NP_001074243.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 4. The resulting isoform (b) has a shorter N terminus when compared to isoform c. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK004743, AK166638, AL591440
      Consensus CDS
      CCDS25054.1
      UniProtKB/Swiss-Prot
      Q9WTI7
      Related
      ENSMUSP00000099562.4, ENSMUST00000102504.10
      Conserved Domains (4) summary
      smart00015
      Location:721741
      IQ; Calmodulin-binding motif
      smart00242
      Location:8693
      MYSc; Myosin. Large ATPases
      cd01378
      Location:27683
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:8391006
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    2. NM_001080775.1NP_001074244.1  unconventional myosin-Ic isoform a

      See identical proteins and their annotated locations for NP_001074244.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 4. The encoded isoform (a) is shorter than isoform c. This isoform is also known as nuclear myosin I.
      Source sequence(s)
      AK004743, AL591440, CK020066
      Consensus CDS
      CCDS36228.1
      UniProtKB/Swiss-Prot
      Q9WTI7
      Related
      ENSMUSP00000104069.3, ENSMUST00000108431.3
      Conserved Domains (4) summary
      smart00015
      Location:737757
      IQ; Calmodulin-binding motif
      smart00242
      Location:24709
      MYSc; Myosin. Large ATPases
      cd01378
      Location:43699
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:8551022
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    3. NM_001370611.1NP_001357540.1  unconventional myosin-Ic isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (c)
      Source sequence(s)
      AL591440
      Consensus CDS
      CCDS88191.1
      Related
      ENSMUSP00000099563.4, ENSMUST00000102505.10
      Conserved Domains (3) summary
      smart00015
      Location:756776
      IQ; Calmodulin-binding motif
      cd01378
      Location:62718
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:8741038
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    4. NM_008659.3NP_032685.1  unconventional myosin-Ic isoform b

      See identical proteins and their annotated locations for NP_032685.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 4. The resulting isoform (b) has a shorter N terminus when compared to isoform c. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK004743, AL591440, BY310607
      Consensus CDS
      CCDS25054.1
      UniProtKB/Swiss-Prot
      Q9WTI7
      Related
      ENSMUSP00000070388.7, ENSMUST00000069057.13
      Conserved Domains (4) summary
      smart00015
      Location:721741
      IQ; Calmodulin-binding motif
      smart00242
      Location:8693
      MYSc; Myosin. Large ATPases
      cd01378
      Location:27683
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:8391006
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      75541345..75565469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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