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    Myo1b myosin IB [ Mus musculus (house mouse) ]

    Gene ID: 17912, updated on 8-Jul-2021

    Summary

    Official Symbol
    Myo1bprovided by MGI
    Official Full Name
    myosin IBprovided by MGI
    Primary source
    MGI:MGI:107752
    See related
    Ensembl:ENSMUSG00000018417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MMIa; MIH-L; AA406997
    Expression
    Broad expression in CNS E11.5 (RPKM 15.5), CNS E14 (RPKM 12.3) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Myo1b in Genome Data Viewer
    Location:
    1 C1.1; 1 26.58 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (51788917..51955143, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (51749758..51916063, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (51806609..51972818, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17767 Neighboring gene predicted gene, 31636 Neighboring gene predicted gene, 33795 Neighboring gene predicted gene 8419 Neighboring gene ribosomal protein L15 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament-based movement ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within transferrin transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vesicle transport along actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in brush border IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    unconventional myosin-Ib
    Names
    MMI-alpha
    Myosin IA (Myosin I alpha) (MMI-alpha) (MMIa) (MIH-L)
    molecular motor
    myosin I alpha
    myosin-Ib

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161817.2NP_001155289.1  unconventional myosin-Ib isoform 1

      See identical proteins and their annotated locations for NP_001155289.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AC108840, BB768105, BC054786, BE950809, BY759345
      Consensus CDS
      CCDS48254.1
      UniProtKB/TrEMBL
      Q7TQD7
      Related
      ENSMUSP00000018561.8, ENSMUST00000018561.14
      Conserved Domains (3) summary
      smart00015
      Location:749771
      IQ; Calmodulin-binding motif
      cd01378
      Location:29688
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:9411118
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    2. NM_001290982.1NP_001277911.1  unconventional myosin-Ib isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the 3' coding region, compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
      Source sequence(s)
      AC108840, AK161062, BB768105, BC054786, BE950809, BY759345
      Consensus CDS
      CCDS69887.1
      UniProtKB/TrEMBL
      E9QNH6, Q3TTZ3, Q7TQD7
      Related
      ENSMUSP00000110184.3, ENSMUST00000114537.9
      Conserved Domains (4) summary
      smart00015
      Location:749771
      IQ; Calmodulin-binding motif
      smart00242
      Location:16701
      MYSc; Myosin. Large ATPases
      cd01378
      Location:29688
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:8831057
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    3. NM_010863.4NP_034993.2  unconventional myosin-Ib isoform 2

      See identical proteins and their annotated locations for NP_034993.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC108840, AK141207, BB768105, BC054786, BE950809, BY759345
      Consensus CDS
      CCDS14942.1
      UniProtKB/Swiss-Prot
      P46735
      UniProtKB/TrEMBL
      Q7TQD7
      Related
      ENSMUSP00000040447.8, ENSMUST00000046390.14
      Conserved Domains (4) summary
      smart00015
      Location:749771
      IQ; Calmodulin-binding motif
      smart00242
      Location:16701
      MYSc; Myosin. Large ATPases
      cd01378
      Location:29688
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:9121086
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      51788917..51955143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495765.4XP_006495828.1  unconventional myosin-Ib isoform X1

      See identical proteins and their annotated locations for XP_006495828.1

      Conserved Domains (3) summary
      smart00015
      Location:751773
      IQ; Calmodulin-binding motif
      cd01378
      Location:29690
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:9431120
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    2. XM_030252028.2XP_030107888.1  unconventional myosin-Ib isoform X2

      Conserved Domains (3) summary
      smart00015
      Location:749771
      IQ; Calmodulin-binding motif
      cd01378
      Location:29688
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:9411118
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    3. XM_017319213.1XP_017174702.1  unconventional myosin-Ib isoform X7

      Conserved Domains (3) summary
      smart00015
      Location:628650
      IQ; Calmodulin-binding motif
      cl22853
      Location:1567
      Motor_domain; Myosin and Kinesin motor domain
      pfam06017
      Location:791968
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    4. XM_036162635.1XP_036018528.1  unconventional myosin-Ib isoform X6

      Conserved Domains (3) summary
      smart00015
      Location:628650
      IQ; Calmodulin-binding motif
      pfam06017
      Location:820997
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
      cl22853
      Location:1567
      Motor_domain; Myosin and Kinesin motor domain
    5. XM_006495769.3XP_006495832.1  unconventional myosin-Ib isoform X5

      Conserved Domains (3) summary
      smart00015
      Location:630652
      IQ; Calmodulin-binding motif
      cl22853
      Location:1569
      Motor_domain; Myosin and Kinesin motor domain
      pfam06017
      Location:822999
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    6. XM_006495767.4XP_006495830.1  unconventional myosin-Ib isoform X4

      Conserved Domains (3) summary
      smart00015
      Location:751773
      IQ; Calmodulin-binding motif
      cd01378
      Location:29690
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:8851062
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    7. XM_006495766.4XP_006495829.1  unconventional myosin-Ib isoform X3

      Conserved Domains (3) summary
      smart00015
      Location:751773
      IQ; Calmodulin-binding motif
      cd01378
      Location:29690
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:9141091
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    8. XM_006495764.4XP_006495827.1  unconventional myosin-Ib isoform X1

      See identical proteins and their annotated locations for XP_006495827.1

      Conserved Domains (3) summary
      smart00015
      Location:751773
      IQ; Calmodulin-binding motif
      cd01378
      Location:29690
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:9431120
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
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