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    Myo10 myosin X [ Mus musculus (house mouse) ]

    Gene ID: 17909, updated on 19-Sep-2021

    Summary

    Official Symbol
    Myo10provided by MGI
    Official Full Name
    myosin Xprovided by MGI
    Primary source
    MGI:MGI:107716
    See related
    Ensembl:ENSMUSG00000022272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    myos; AW048724; myosin-X; mKIAA0799; D15Ertd600; D15Ertd600e
    Expression
    Ubiquitous expression in lung adult (RPKM 20.6), ovary adult (RPKM 15.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Myo10 in Genome Data Viewer
    Location:
    15 B1; 15 9.36 cM
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (25622636..25813759)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (25622550..25813673)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (25552305..25743426)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 48957 Neighboring gene predicted gene, 36642 Neighboring gene PCNA-associated factor pseudogene Neighboring gene reticulophagy regulator 1 Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene 15_175.1 Neighboring gene microRNA 7212

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    unconventional myosin-X
    Names
    unconventional myosin-10
    unconventionnal myosin-X

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001353141.1NP_001340070.1  unconventional myosin-X isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC131178
      Conserved Domains (8) summary
      smart00139
      Location:9111057
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10661320
      B41; Band 4.1 homologues
      cd13202
      Location:13161404
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:577678
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:743868
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl17171
      Location:543585
      PH-like; Pleckstrin homology-like domain
      cl22853
      Location:285
      Motor_domain; Myosin and Kinesin motor domain
      cl27381
      Location:3334
      Myosin_head; Myosin head (motor domain)
    2. NM_001353142.1NP_001340071.1  unconventional myosin-X isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK122371
      Consensus CDS
      CCDS88740.1
      Related
      ENSMUSP00000022882.6, ENSMUST00000022882.12
      Conserved Domains (10) summary
      smart00139
      Location:807953
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:9621216
      B41; Band 4.1 homologues
      cd13202
      Location:12121300
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:473574
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:639764
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      TIGR02168
      Location:94235
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd17206
      Location:9551050
      FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
      pfam16735
      Location:136186
      MYO10_CC; Unconventional myosin-X coiled coil domain
      NF033609
      Location:243426
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
      cl17171
      Location:439481
      PH-like; Pleckstrin homology-like domain
    3. NM_019472.2NP_062345.2  unconventional myosin-X isoform 1

      See identical proteins and their annotated locations for NP_062345.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK028552, AK089482, AK122371
      Consensus CDS
      CCDS37049.1
      UniProtKB/Swiss-Prot
      F8VQB6
      UniProtKB/TrEMBL
      Q80TR9
      Related
      ENSMUSP00000106087.2, ENSMUST00000110457.8
      Conserved Domains (15) summary
      smart00015
      Location:741763
      IQ; Calmodulin-binding motif
      smart00139
      Location:15531699
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:58739
      MYSc; Myosin. Large ATPases
      smart00295
      Location:17081962
      B41; Band 4.1 homologues
      cd13202
      Location:19582046
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:12191320
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:13851510
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd14873
      Location:77727
      MYSc_Myo10; class X myosin, motor domain
      pfam00169
      Location:12191314
      PH; PH domain
      pfam00373
      Location:18031962
      FERM_M; FERM central domain
      pfam15346
      Location:796939
      ARGLU; Arginine and glutamate-rich 1
      pfam16735
      Location:882932
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:17051750
      UBQ; Ubiquitin-like proteins
      cl02488
      Location:843957
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:11851227
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      25622636..25813759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248368.2XP_030104228.1  unconventional myosin-X isoform X1

      Conserved Domains (9) summary
      smart00139
      Location:9101056
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10651319
      B41; Band 4.1 homologues
      COG5022
      Location:2333
      COG5022; Myosin heavy chain [General function prediction only]
      cd13202
      Location:13151403
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:576677
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:742867
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd17206
      Location:10581153
      FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
      cl22853
      Location:184
      Motor_domain; Myosin and Kinesin motor domain
      cl17171
      Location:542584
      PH-like; Pleckstrin homology-like domain
    2. XM_030248369.1XP_030104229.1  unconventional myosin-X isoform X1

      Conserved Domains (9) summary
      smart00139
      Location:9101056
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10651319
      B41; Band 4.1 homologues
      COG5022
      Location:2333
      COG5022; Myosin heavy chain [General function prediction only]
      cd13202
      Location:13151403
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:576677
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:742867
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd17206
      Location:10581153
      FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
      cl22853
      Location:184
      Motor_domain; Myosin and Kinesin motor domain
      cl17171
      Location:542584
      PH-like; Pleckstrin homology-like domain
    3. XM_036159219.1XP_036015112.1  unconventional myosin-X isoform X3

      Conserved Domains (10) summary
      smart00139
      Location:807953
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:9621216
      B41; Band 4.1 homologues
      cd13202
      Location:12121300
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:473574
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:639764
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      TIGR02168
      Location:94235
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd17206
      Location:9551050
      FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
      pfam16735
      Location:136186
      MYO10_CC; Unconventional myosin-X coiled coil domain
      NF033609
      Location:243426
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
      cl17171
      Location:439481
      PH-like; Pleckstrin homology-like domain
    4. XM_006520025.5XP_006520088.1  unconventional myosin-X isoform X1

      UniProtKB/Swiss-Prot
      F8VQB6
      Conserved Domains (9) summary
      smart00139
      Location:9101056
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10651319
      B41; Band 4.1 homologues
      COG5022
      Location:2333
      COG5022; Myosin heavy chain [General function prediction only]
      cd13202
      Location:13151403
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:576677
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:742867
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd17206
      Location:10581153
      FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
      cl22853
      Location:184
      Motor_domain; Myosin and Kinesin motor domain
      cl17171
      Location:542584
      PH-like; Pleckstrin homology-like domain
    5. XM_006520026.5XP_006520089.1  unconventional myosin-X isoform X2

      Conserved Domains (10) summary
      smart00139
      Location:831977
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:9861240
      B41; Band 4.1 homologues
      COG4372
      Location:5232
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13202
      Location:12361324
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:497598
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:663788
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      TIGR02680
      Location:122259
      TIGR02680; TIGR02680 family protein
      cd17206
      Location:9791074
      FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
      pfam16735
      Location:160210
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl17171
      Location:463505
      PH-like; Pleckstrin homology-like domain
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