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    Myl6 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle [ Mus musculus (house mouse) ]

    Gene ID: 17904, updated on 31-Aug-2021

    Summary

    Official Symbol
    Myl6provided by MGI
    Official Full Name
    myosin, light polypeptide 6, alkali, smooth muscle and non-muscleprovided by MGI
    Primary source
    MGI:MGI:109318
    See related
    Ensembl:ENSMUSG00000090841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    My; LC17; MLC3; Myln; ESMLC; MLC-3; MLC1SM; LC17-GI
    Expression
    Broad expression in bladder adult (RPKM 2188.3), placenta adult (RPKM 580.4) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Myl6 in Genome Data Viewer
    Location:
    10; 10 D3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128326728..128329755, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128490859..128493886, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127927917..127930881, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene microRNA 8105 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 Neighboring gene myosin, light polypeptide 6B Neighboring gene Riken cDNA A430046D13 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC106465, MGC107135

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytoskeletal motor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of muscle ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of muscle TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in muscle contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in muscle filament sliding TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in skeletal muscle tissue development TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of unconventional myosin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    myosin light polypeptide 6
    Names
    17 kDa myosin light chain
    myosin light chain A3
    myosin light chain alkali 3
    myosin light chain, alkali, nonmuscle
    smooth muscle and nonmuscle myosin light chain alkali 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317217.1NP_001304146.1  myosin light polypeptide 6 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a)
      Source sequence(s)
      AV079576, BC081470, BY244415, CF739680
      Consensus CDS
      CCDS88111.1
      UniProtKB/TrEMBL
      A0A1W2P7Q9, Q642K0
      Related
      ENSMUSP00000151915.2, ENSMUST00000219236.2
      Conserved Domains (3) summary
      smart00054
      Location:1139
      EFh; EF-hand, calcium binding motif
      cd00051
      Location:94144
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl08302
      Location:1175
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. NM_001317218.1NP_001304147.1  myosin light polypeptide 6 isoform MLC3nm

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, resulting in a framehsift and a novel 3' UTR, compared to variant 1. The encoded isoform (MLC3nm, also known as LC17A and LC17-nm) has a distinct C-terminus and is shorter than isoform a. Isoform MLC3nm and MLC3sm are the same length but differ in their C-termini.
      Source sequence(s)
      AV079576, BY244415, DV064657
      Consensus CDS
      CCDS88112.1
      UniProtKB/Swiss-Prot
      Q60605
      Related
      ENSMUSP00000151693.2, ENSMUST00000218127.2
      Conserved Domains (1) summary
      PTZ00184
      Location:5150
      PTZ00184; calmodulin; Provisional
    3. NM_001317219.1NP_001304148.1  myosin light polypeptide 6 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in distinct 5' and 3' UTRs, translation initiation at a downstream start codon, and a frameshift, compared to variant 1. The encoded isoform (b) has a shorter N-terminus and a distinct C-terminus, compared to isoform a. Isoforms b and c are the same length but differ in their C-termini.
      Source sequence(s)
      AC170752, AV079576, DV061693
      Conserved Domains (1) summary
      PTZ00184
      Location:1115
      PTZ00184; calmodulin; Provisional
    4. NM_001317220.1NP_001304149.1  myosin light polypeptide 6 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences, compared to variant 1. These differences result in distinct 5' and 3' UTRs, translation initiation at a downstream start codon, and a frameshift, compared to variant 1. The encoded isoform (c) has a shorter N-terminus and a distinct C-terminus, compared to isoform a. Isoforms b and c are the same length but differ in their C-termini.
      Source sequence(s)
      AC170752, AV079576, BC081470, CJ043320, DV061693
      UniProtKB/TrEMBL
      Q642K0
      Conserved Domains (1) summary
      PTZ00184
      Location:1114
      PTZ00184; calmodulin; Provisional
    5. NM_010860.4NP_034990.1  myosin light polypeptide 6 isoform MLC3sm

      See identical proteins and their annotated locations for NP_034990.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region, resulting in a frameshift and a novel 3' UTR, compared to variant 1. The encoded isoform (MLC3sm, also known as LC17B and LC17-sm) has a distinct C-terminus and is shorter than isoform a. Isoform MLC3sm and MLC3nm are the same length but differ in their C-termini. Isoforms b and c are the same length but differ in their C-termini.
      Source sequence(s)
      AV079576, BC081470, BY244415
      Consensus CDS
      CCDS48728.1
      UniProtKB/Swiss-Prot
      Q60605
      UniProtKB/TrEMBL
      Q642K0
      Related
      ENSMUSP00000128803.2, ENSMUST00000164181.2
      Conserved Domains (1) summary
      PTZ00184
      Location:5149
      PTZ00184; calmodulin; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128326728..128329755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155669.1XP_036011562.1  myosin light polypeptide 6 isoform X1

      Conserved Domains (1) summary
      PTZ00184
      Location:1114
      PTZ00184; calmodulin; Provisional
    2. XM_036155670.1XP_036011563.1  myosin light polypeptide 6 isoform X2

      Conserved Domains (1) summary
      PTZ00184
      Location:1115
      PTZ00184; calmodulin; Provisional
    3. XM_030244939.2XP_030100799.1  myosin light polypeptide 6 isoform X2

      Conserved Domains (1) summary
      PTZ00184
      Location:1115
      PTZ00184; calmodulin; Provisional
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