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    Myh9 myosin, heavy polypeptide 9, non-muscle [ Mus musculus (house mouse) ]

    Gene ID: 17886, updated on 26-Sep-2022

    Summary

    Official Symbol
    Myh9provided by MGI
    Official Full Name
    myosin, heavy polypeptide 9, non-muscleprovided by MGI
    Primary source
    MGI:MGI:107717
    See related
    Ensembl:ENSMUSG00000022443 AllianceGenome:MGI:107717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fltn; Myhn1; Myhn-1; TU72.6; NMHCIIA; NMMHC-A; NMMHC-IIA
    Summary
    Enables protein domain specific binding activity. Involved in several processes, including cortical granule exocytosis; negative regulation of actin filament severing; and positive regulation of protein processing in phagocytic vesicle. Acts upstream of or within several processes, including establishment of T cell polarity; microtubule cytoskeleton organization; and myoblast fusion. Located in several cellular components, including cortical granule; cytoskeleton; and immunological synapse. Part of myosin II complex. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system; early embryo; future spinal cord; heart and pericardium; and sensory organ. Used to study MYH-9 related disease. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and orofacial cleft. Orthologous to human MYH9 (myosin heavy chain 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 64.5), spleen adult (RPKM 64.1) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Myh9 in Genome Data Viewer
    Location:
    15 E1; 15 36.81 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (77644785..77726375, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (77760585..77842175, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein L 9b Neighboring gene apolipoprotein L 8 Neighboring gene VISTA enhancer mm1644 Neighboring gene predicted gene, 22107 Neighboring gene predicted gene, 53901 Neighboring gene thioredoxin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • E030044M24Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables follicle-stimulating hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-membrane adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament bundle distribution ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in actin filament capping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within actin filament-based movement ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actomyosin structure organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell morphogenesis involved in differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cortical granule exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytokinetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of T cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of meiotic spindle localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in follicle-stimulating hormone signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lysosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within meiotic spindle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of actin filament severing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of actin filament severing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in plasma membrane repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inositol trisphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein processing in phagocytic vesicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of plasma membrane repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within uropod organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actomyosin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actomyosin contractile ring ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cortical granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    colocalizes_with endosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of myosin II complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of myosin II complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myosin II filament ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in uropod IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in uropod ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    myosin-9
    Names
    NMHC II-A
    NMMHC II-a
    cellular myosin heavy chain, type A
    flectin
    myosin IIA
    myosin heavy chain IX
    non-muscle myosin heavy chain IIa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022410.3NP_071855.2  myosin-9

      See identical proteins and their annotated locations for NP_071855.2

      Status: VALIDATED

      Source sequence(s)
      AK147211, CJ130312, CJ240806
      Consensus CDS
      CCDS27605.1
      UniProtKB/Swiss-Prot
      Q811I2, Q8VDD5
      Related
      ENSMUSP00000016771.7, ENSMUST00000016771.13
      Conserved Domains (8) summary
      cl22853
      Location:95764
      Motor_domain; Myosin and Kinesin motor domain
      pfam00063
      Location:83764
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8421921
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3068
      Myosin_N; Myosin N-terminal SH3-like domain
      cl00240
      Location:12061261
      RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...
      cl02376
      Location:16101678
      DUF2390; Protein of unknown function (DUF2390)
      cl15254
      Location:10381149
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      cl23720
      Location:14801587
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      77644785..77726375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)