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    Myef2 myelin basic protein expression factor 2, repressor [ Mus musculus (house mouse) ]

    Gene ID: 17876, updated on 23-Jun-2021

    Summary

    Official Symbol
    Myef2provided by MGI
    Official Full Name
    myelin basic protein expression factor 2, repressorprovided by MGI
    Primary source
    MGI:MGI:104592
    See related
    Ensembl:ENSMUSG00000027201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1341; 9430071B01
    Expression
    Broad expression in CNS E11.5 (RPKM 22.6), CNS E14 (RPKM 21.9) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Myef2 in Genome Data Viewer
    Location:
    2 F1; 2 61.16 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (124922895..124966727, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (125080975..125123660, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (124912007..124949396, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39920 Neighboring gene predicted gene, 52495 Neighboring gene solute carrier family 24, member 5 Neighboring gene predicted gene, 22352 Neighboring gene predicted gene, 46759 Neighboring gene cortexin 2 Neighboring gene solute carrier family 12, member 1 Neighboring gene predicted gene, 46760

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of post-mRNA release spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    myelin expression factor 2
    Names
    MEF-2
    myEF-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162417.1NP_001155889.1  myelin expression factor 2 isoform 1

      See identical proteins and their annotated locations for NP_001155889.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK048404, AK143230, BY711324
      Consensus CDS
      CCDS50691.1
      UniProtKB/Swiss-Prot
      Q8C854
      UniProtKB/TrEMBL
      A7UQY4
      Related
      ENSMUSP00000123088.2, ENSMUST00000152367.8
      Conserved Domains (4) summary
      TIGR01628
      Location:115587
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12660
      Location:224299
      RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:515591
      RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)
    2. NM_001162418.1NP_001155890.1  myelin expression factor 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the middle portion of the coding region and differs in the 3' UTR, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AK012133, AK143230, AL928902, BB647288, BY711324
      Consensus CDS
      CCDS50689.1
      UniProtKB/TrEMBL
      A2ATP5, A7UQY4
      Related
      ENSMUSP00000114817.2, ENSMUST00000147105.8
      Conserved Domains (4) summary
      TIGR01628
      Location:115546
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:226299
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:474550
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    3. NM_010852.2NP_034982.2  myelin expression factor 2 isoform 2

      See identical proteins and their annotated locations for NP_034982.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the middle portion of the coding region and differs in the 3' UTR, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK012133, AK143230, AL928902, BB647288, BY711324
      Consensus CDS
      CCDS50690.1
      UniProtKB/TrEMBL
      A7UQY4
      Related
      ENSMUSP00000066312.4, ENSMUST00000067780.10
      Conserved Domains (4) summary
      TIGR01628
      Location:115570
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:226299
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:498574
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      124922895..124966727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248228.2XP_030104088.1  myelin expression factor 2 isoform X3

      Conserved Domains (4) summary
      TIGR01628
      Location:115546
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:226299
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:474550
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    2. XM_006498884.4XP_006498947.1  myelin expression factor 2 isoform X2

      See identical proteins and their annotated locations for XP_006498947.1

      UniProtKB/Swiss-Prot
      Q8C854
      Conserved Domains (4) summary
      TIGR01628
      Location:115570
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:226299
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:498574
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    3. XM_017316131.3XP_017171620.1  myelin expression factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8C854
      Conserved Domains (4) summary
      TIGR01628
      Location:115587
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12660
      Location:224299
      RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:515591
      RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)
    4. XM_017316134.3XP_017171623.1  myelin expression factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8C854
      Conserved Domains (4) summary
      TIGR01628
      Location:115587
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12660
      Location:224299
      RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:515591
      RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)
    5. XM_017316132.3XP_017171621.1  myelin expression factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8C854
      Conserved Domains (4) summary
      TIGR01628
      Location:115587
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12660
      Location:224299
      RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:515591
      RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)
    6. XM_036159095.1XP_036014988.1  myelin expression factor 2 isoform X1

      Conserved Domains (4) summary
      TIGR01628
      Location:115587
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12660
      Location:224299
      RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:515591
      RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

    RNA

    1. XR_001781149.3 RNA Sequence

    2. XR_001781148.3 RNA Sequence

    3. XR_004938788.1 RNA Sequence

    4. XR_004938787.1 RNA Sequence

    5. XR_001781147.3 RNA Sequence

    6. XR_001781150.1 RNA Sequence

    7. XR_001781152.3 RNA Sequence

    8. XR_004938789.1 RNA Sequence

    9. XR_001781151.3 RNA Sequence

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