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    Mybl2 myeloblastosis oncogene-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 17865, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mybl2provided by MGI
    Official Full Name
    myeloblastosis oncogene-like 2provided by MGI
    Primary source
    MGI:MGI:101785
    See related
    Ensembl:ENSMUSG00000017861 AllianceGenome:MGI:101785
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bmyb; B-Myb
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor and mitotic spindle assembly. Located in nucleus. Part of Myb complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system; and skin. Used to study acute myeloid leukemia and myelodysplastic syndrome. Orthologous to human MYBL2 (MYB proto-oncogene like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14.5 (RPKM 17.0), liver E14 (RPKM 15.7) and 17 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mybl2 in Genome Data Viewer
    Location:
    2 H2; 2 84.0 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (162896246..162926608)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163054327..163084688)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene serum/glucocorticoid regulated kinase 2 Neighboring gene STARR-seq mESC enhancer starr_06293 Neighboring gene intraflagellar transport 52 Neighboring gene STARR-seq mESC enhancer starr_06295 Neighboring gene STARR-positive B cell enhancer ABC_E6013 Neighboring gene STARR-seq mESC enhancer starr_06298 Neighboring gene microRNA 7003 Neighboring gene gametocyte specific factor 1-like Neighboring gene predicted gene 11454

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of Myb complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    myb-related protein B
    Names
    myb-like protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008652.2NP_032678.1  myb-related protein B

      See identical proteins and their annotated locations for NP_032678.1

      Status: PROVISIONAL

      Source sequence(s)
      AK028497
      Consensus CDS
      CCDS17006.1
      UniProtKB/Swiss-Prot
      P48972
      Related
      ENSMUSP00000018005.4, ENSMUST00000018005.10
      Conserved Domains (4) summary
      smart00717
      Location:83131
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:83129
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam09316
      Location:454599
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:3494
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      162896246..162926608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498875.5XP_006498938.1  myb-related protein B isoform X2

      Conserved Domains (3) summary
      PLN03091
      Location:81219
      PLN03091; hypothetical protein; Provisional
      pfam09316
      Location:317497
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:3494
      Myb_DNA-bind_6; Myb-like DNA-binding domain
    2. XM_006498876.5XP_006498939.1  myb-related protein B isoform X3

      See identical proteins and their annotated locations for XP_006498939.1

      Conserved Domains (2) summary
      PLN03091
      Location:257
      PLN03091; hypothetical protein; Provisional
      pfam09316
      Location:292476
      Cmyb_C; C-myb, C-terminal
    3. XM_006498873.5XP_006498936.1  myb-related protein B isoform X1

      Conserved Domains (3) summary
      PLN03091
      Location:81219
      PLN03091; hypothetical protein; Provisional
      pfam09316
      Location:454638
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:3494
      Myb_DNA-bind_6; Myb-like DNA-binding domain
    4. XM_006498878.5XP_006498941.1  myb-related protein B isoform X4

      Conserved Domains (3) summary
      PLN03091
      Location:81219
      PLN03091; hypothetical protein; Provisional
      pfam09316
      Location:317458
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:3494
      Myb_DNA-bind_6; Myb-like DNA-binding domain