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    Mybl1 myeloblastosis oncogene-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 17864, updated on 2-Oct-2018

    Summary

    Official Symbol
    Mybl1provided by MGI
    Official Full Name
    myeloblastosis oncogene-like 1provided by MGI
    Primary source
    MGI:MGI:99925
    See related
    Ensembl:ENSMUSG00000025912 Vega:OTTMUSG00000034736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A-myb; repro9; G1-419-6
    Expression
    Biased expression in CNS E11.5 (RPKM 1.8), testis adult (RPKM 1.4) and 14 other tissues See more
    Orthologs

    Genomic context

    See Mybl1 in Genome Data Viewer
    Location:
    1 A2; 1 2.08 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (9667407..9700439, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (9658912..9690290, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2610203C22 gene Neighboring gene alcohol dehydrogenase, iron containing, 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene vexin Neighboring gene valosin containing protein (p97)/p47 complex interacting protein 1 Neighboring gene RIKEN cDNA 1700034P13 gene Neighboring gene predicted gene, 39590

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC123416

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transposition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    piRNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    myb-related protein A
    Names
    myb-like protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290397.1NP_001277326.1  myb-related protein A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC103620, AC158790
      Consensus CDS
      CCDS69861.1
      UniProtKB/TrEMBL
      E9QLX9
      Related
      ENSMUSP00000111128.2, OTTMUSP00000048088, ENSMUST00000115468.8, OTTMUST00000088261
      Conserved Domains (4) summary
      smart00717
      Location:87135
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:87133
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:242285
      LMSTEN; LMSTEN motif
      pfam09316
      Location:485646
      Cmyb_C; C-myb, C-terminal
    2. NM_008651.3NP_032677.2  myb-related protein A isoform 1

      See identical proteins and their annotated locations for NP_032677.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC103620, AC158790
      Consensus CDS
      CCDS35510.1
      UniProtKB/Swiss-Prot
      P51960
      UniProtKB/TrEMBL
      A0A0R4J132
      Related
      ENSMUSP00000086034.4, OTTMUSP00000048087, ENSMUST00000088658.10, OTTMUST00000088260
      Conserved Domains (4) summary
      smart00717
      Location:87135
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:87133
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:242285
      LMSTEN; LMSTEN motif
      pfam09316
      Location:485646
      Cmyb_C; C-myb, C-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      9667407..9700439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495461.1XP_006495524.1  myb-related protein A isoform X1

      Conserved Domains (3) summary
      smart00717
      Location:87135
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:87133
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam09316
      Location:450611
      Cmyb_C; C-myb, C-terminal
    2. XM_011238350.2XP_011236652.1  myb-related protein A isoform X3

      Conserved Domains (1) summary
      pfam09316
      Location:211372
      Cmyb_C; C-myb, C-terminal
    3. XM_011238349.1XP_011236651.1  myb-related protein A isoform X2

      Conserved Domains (4) summary
      smart00717
      Location:87135
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:87133
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:242285
      LMSTEN; LMSTEN motif
      pfam09316
      Location:485646
      Cmyb_C; C-myb, C-terminal
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