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    Usp34 ubiquitin specific peptidase 34 [ Mus musculus (house mouse) ]

    Gene ID: 17847, updated on 19-Sep-2021

    Summary

    Official Symbol
    Usp34provided by MGI
    Official Full Name
    ubiquitin specific peptidase 34provided by MGI
    Primary source
    MGI:MGI:109473
    See related
    Ensembl:ENSMUSG00000056342
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mur; Murr2; A530081C03Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 12.8), CNS E14 (RPKM 10.9) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Usp34 in Genome Data Viewer
    Location:
    11 A3.2; 11 14.29 cM
    Exon count:
    80
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23256433..23440560)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23303185..23490560)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (23206895..23390560)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24398 Neighboring gene exportin 1 Neighboring gene RIKEN cDNA 1700030C12 gene Neighboring gene predicted gene, 22753 Neighboring gene RIKEN cDNA 1700093K21 gene Neighboring gene AHA1, activator of heat shock protein ATPase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thiol-dependent deubiquitinase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables thiol-dependent deubiquitinase ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 34
    Names
    U2af1-rs1 region 2
    deubiquitinating enzyme 34
    ubiquitin specific protease 34
    ubiquitin thioesterase 34
    ubiquitin thiolesterase 34
    ubiquitin-specific-processing protease 34
    NP_001177330.2
    XP_006514628.1
    XP_006514629.1
    XP_006514630.1
    XP_017169806.1
    XP_030101492.1
    XP_030101493.1
    XP_036012290.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190401.2NP_001177330.2  ubiquitin carboxyl-terminal hydrolase 34

      See identical proteins and their annotated locations for NP_001177330.2

      Status: INFERRED

      Source sequence(s)
      AL672004, AL672049, AL772359, AL928722
      Consensus CDS
      CCDS56763.1
      UniProtKB/Swiss-Prot
      Q6ZQ93
      Related
      ENSMUSP00000137430.2, ENSMUST00000180046.8
      Conserved Domains (2) summary
      cd02659
      Location:19292278
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:19312273
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      23256433..23440560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514566.4XP_006514629.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X2

      Conserved Domains (1) summary
      cd02659
      Location:19182267
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    2. XM_006514565.3XP_006514628.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X1

      Conserved Domains (1) summary
      cd02659
      Location:19302279
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    3. XM_006514567.3XP_006514630.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X4

      Conserved Domains (1) summary
      cd02659
      Location:19302279
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    4. XM_017314317.3XP_017169806.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X5

      Conserved Domains (1) summary
      cd02659
      Location:19292278
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    5. XM_036156397.1XP_036012290.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X3

      Conserved Domains (2) summary
      cd02659
      Location:18922241
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12030
      Location:23592692
      DUF3517; Domain of unknown function (DUF3517)
    6. XM_030245632.2XP_030101492.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X6

      Conserved Domains (1) summary
      cd02659
      Location:17312080
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    7. XM_030245633.2XP_030101493.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X7

      Conserved Domains (1) summary
      cd02659
      Location:17192068
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
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