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    Commd1 COMM domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 17846, updated on 31-Jan-2019

    Summary

    Official Symbol
    Commd1provided by MGI
    Official Full Name
    COMM domain containing 1provided by MGI
    Primary source
    MGI:MGI:109474
    See related
    Ensembl:ENSMUSG00000051355
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Murr1; U2/Mu; AI256843
    Expression
    Ubiquitous expression in testis adult (RPKM 10.4), CNS E11.5 (RPKM 10.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Commd1 in Genome Data Viewer
    Location:
    11 A3.2; 11 14.22 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (22899728..22983108, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (22799728..22882284, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Neighboring gene uncharacterized LOC108167890 Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1 Neighboring gene chaperonin containing Tcp1, subunit 4 (delta) Neighboring gene family with sequence similarity 161, member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    sodium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Golgi to plasma membrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    cellular copper ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    copper ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    copper ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    low-density lipoprotein particle clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of hypoxia-inducible factor-1alpha signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein localization to cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane to endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endosome to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of plasma lipoprotein particle levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    COMM domain-containing protein 1
    Names
    U2af1-rs1 region 1
    copper metabolism domain containing 1
    protein Murr1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361661.1NP_001348590.1  COMM domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL772364, BB053099, BU582903, CX567872
      Conserved Domains (1) summary
      cl06336
      Location:1119
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
    2. NM_144514.2NP_653097.2  COMM domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_653097.2

      Status: VALIDATED

      Source sequence(s)
      AK133507, BB053099, BY337798
      Consensus CDS
      CCDS24472.1
      UniProtKB/Swiss-Prot
      Q8K4M5
      UniProtKB/TrEMBL
      A2RSF1
      Related
      ENSMUSP00000124719.1, ENSMUST00000159081.7
      Conserved Domains (1) summary
      cd04749
      Location:11184
      Commd1_MURR1; COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      22899728..22983108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314316.1XP_017169805.1  COMM domain-containing protein 1 isoform X3

      Related
      ENSMUSP00000053606.5, ENSMUST00000057843.11
    2. XM_006514564.3XP_006514627.1  COMM domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      cl06336
      Location:1119
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
    3. XM_006514563.3XP_006514626.1  COMM domain-containing protein 1 isoform X1

      Related
      ENSMUSP00000090958.5, ENSMUST00000093270.5
      Conserved Domains (1) summary
      cd04749
      Location:11156
      Commd1_MURR1; COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a ...
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